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Chemical Compound Review

octopamine     4-(2-amino-1-hydroxy- ethyl)phenol

Synonyms: Norphen, Analet, Norden, Norfen, Octapamine, ...
 
 
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Disease relevance of Norsynephrine

 

Psychiatry related information on Norsynephrine

 

High impact information on Norsynephrine

 

Chemical compound and disease context of Norsynephrine

 

Biological context of Norsynephrine

 

Anatomical context of Norsynephrine

 

Associations of Norsynephrine with other chemical compounds

 

Gene context of Norsynephrine

  • The preincubation of platelet MAO-B with purified MAO-A from mitochondrial membranes of human placenta resulted in appearance of excess octopamine activity [27].
  • The effect of tyramine but not of octopamine was selectively abolished in the TyrR mutant hono, suggesting that this gene encodes a receptor for tyramine, and not for octopamine [32].
  • To test more specifically what role octopamine plays in the antennal lobe, we used two treatments to disrupt an octopamine receptor from Apis mellifera brain (AmOAR) function: (1) an OAR antagonist, mianserin, was used to block receptor function, and (2) AmOAR double-stranded RNA was used to silence receptor expression [33].
  • T beta h-null flies are octopamine-less but survive to adulthood [34].
  • We previously identified one of the Drosophila octopamine receptors named OAMB that produces increases in cAMP and intracellular Ca2+ upon ligand binding [35].
 

Analytical, diagnostic and therapeutic context of Norsynephrine

References

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  14. Hemodynamic effects of ephedra-free weight-loss supplements in humans. Haller, C.A., Benowitz, N.L., Jacob, P. Am. J. Med. (2005) [Pubmed]
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  16. Octopamine and chlordimeform enhance sensory responsiveness and production of the flight motor pattern in developing and adult moths. Kinnamon, S.C., Klaassen, L.W., Kammer, A.E., Claassen, D. J. Neurobiol. (1984) [Pubmed]
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  19. Octopamine enhances dark-adaptation in Limulus ventral photoreceptors. O'Day, P.M., Lisman, J.E. J. Neurosci. (1985) [Pubmed]
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  26. Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility. Cole, S.H., Carney, G.E., McClung, C.A., Willard, S.S., Taylor, B.J., Hirsh, J. J. Biol. Chem. (2005) [Pubmed]
  27. Modification of substrate-inhibitor affinities of human platelet monoamine oxidase B in vitro. Szutowicz, A., Tomaszewicz, M., Orsulak, P.J. J. Biol. Chem. (1989) [Pubmed]
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  32. A trace amine, tyramine, functions as a neuromodulator in Drosophila melanogaster. Nagaya, Y., Kutsukake, M., Chigusa, S.I., Komatsu, A. Neurosci. Lett. (2002) [Pubmed]
  33. Modulation of early olfactory processing by an octopaminergic reinforcement pathway in the honeybee. Farooqui, T., Robinson, K., Vaessin, H., Smith, B.H. J. Neurosci. (2003) [Pubmed]
  34. Characterization of Drosophila tyramine beta-hydroxylase gene and isolation of mutant flies lacking octopamine. Monastirioti, M., Linn, C.E., White, K. J. Neurosci. (1996) [Pubmed]
  35. Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster. Lee, H.G., Seong, C.S., Kim, Y.C., Davis, R.L., Han, K.A. Dev. Biol. (2003) [Pubmed]
  36. Stimulation of pheromone biosynthesis in the moth Helicoverpa zea: action of a brain hormone on pheromone glands involves Ca2+ and cAMP as second messengers. Jurenka, R.A., Jacquin, E., Roelofs, W.L. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  37. Deletions in the genomes of pseudorabies virus vaccine strains and existence of four isomers of the genomes. Lomniczi, B., Blankenship, M.L., Ben-Porat, T. J. Virol. (1984) [Pubmed]
  38. Alterations in brain octopamine and brain tyrosine following portacaval anastomosis in rats. James, J.H., Hodgman, J.M., Funovics, J.M., Fischer, J.E. J. Neurochem. (1976) [Pubmed]
  39. Specific antisera against the catecholamines: L-3,4-dihydroxyphenylalanine, dopamine, noradrenaline, and octopamine tested by an enzyme-linked immunosorbent assay. Mons, N., Geffard, M. J. Neurochem. (1987) [Pubmed]
 
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