Chemical Compound Review:
Ouabaine 4-[1,5,11,14-tetrahydroxy- 10...
Synonyms:
Strophanthin G, AGN-PC-00AX0E, NSC-25485, AC1L1IJG, AC1Q6AXD, ...
- Distinguishing homozygous and heterozygous cystic fibrosis fibroblasts from normal cells by differences in sodium transport. Breslow, J.L., McPherson, J., Epstein, J. N. Engl. J. Med. (1981)
- Evidence of an endogenous digitalis-like factor in the plasma of patients with acromegaly. Deray, G., Rieu, M., Devynck, M.A., Pernollet, M.G., Chanson, P., Luton, J.P., Meyer, P. N. Engl. J. Med. (1987)
- Induction by ouabain of hemoglobin synthesis in cultured Friend erythroleukemic cells. Bernstein, A., Hunt, D.M., Crichley, V., Mak, T.W. Cell (1976)
- Controlling cardiac chaos. Garfinkel, A., Spano, M.L., Ditto, W.L., Weiss, J.N. Science (1992)
- Is pump stimulation associated with positive inotropy of the heart? Michael, L., Pitts, B.J., Schwartz, A. Science (1978)
- Effect of digitalis on left ventricular function in exercising dogs. Horwitz, L.D., Atkins, J.M., Saito, M. Circ. Res. (1977)
- Red cell ouabain-sensitive Na+-K+-adenosine triphosphatase: a state marker in affective disorder inversely related to plasma cortisol. Nurnberger, J., Jimerson, D.C., Allen, J.R., Simmons, S., Gershon, E. Biol. Psychiatry (1982)
- Ouabain binding in the human brain. Effects of Alzheimer's disease and aging. Harik, S.I., Mitchell, M.J., Kalaria, R.N. Arch. Neurol. (1989)
- Centrally administered ouabain aggravates rapid-eye-movement-sleep-related bradyarrhythmias in freely moving rats. Sato, T., Seto, K. Br. J. Pharmacol. (1993)
- Senescence-related changes in the responsiveness to ouabain of canine Purkinje fibers. Hewett, K., Vulliemoz, Y., Rosen, M.R. J. Pharmacol. Exp. Ther. (1982)
- Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts. Larkin, J.M., Brown, M.S., Goldstein, J.L., Anderson, R.G. Cell (1983)
- Hemoglobin synthesis in cell hybrids formed between teratocarcinoma and Friend erythroleukemia cells. McBurney, M.W. Cell (1977)
- Fusion of plasmacytoma and host cells in vivo: selection of proliferating and nonproliferating cultures. Ber, R., Lanir, N. J. Natl. Cancer Inst. (1984)
- Exaggerated triglyceride accretion in human preadipocyte-murine renal line hybrids composed of cells from massively obese subjects. Le Blanc, P.E., Roncari, D.A., Hoar, D.I., Adachi, A.M. J. Clin. Invest. (1988)
- Effect of chronic renal failure on Na,K-ATPase alpha 1 and alpha 2 mRNA transcription in rat skeletal muscle. Bonilla, S., Goecke, I.A., Bozzo, S., Alvo, M., Michea, L., Marusic, E.T. J. Clin. Invest. (1991)
- Effects of amrinone on contraction and K+-induced contracture of normal and subacutely failed cat ventricular muscle. Gaide, M.S., Kimura, S., Lodge, N.J., Cameron, J.S., Kozlovskis, P.L., Myerburg, R.J., Bassett, A.L. Circulation (1986)
- Binding sites related to ouabain-induced stimulation or inhibition of the sodium pump. Godfraind, T., Ghysel-Burton, J. Nature (1977)
- Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle. Iwamoto, T., Kita, S., Zhang, J., Blaustein, M.P., Arai, Y., Yoshida, S., Wakimoto, K., Komuro, I., Katsuragi, T. Nat. Med. (2004)
- Ouabain-like activity in toad skin and its implications for endogenous regulation of ion transport. Flier, J.S. Nature (1978)
- Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Shull, G.E., Schwartz, A., Lingrel, J.B. Nature (1985)
- Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules. Soltoff, S.P., Mandel, L.J. Science (1983)
- Endogenous ouabain-like compound increases heart muscle contractility. Shimoni, Y., Gotsman, M., Deutsch, J., Kachalsky, S., Lichtstein, D. Nature (1984)
- K+ is an endothelium-derived hyperpolarizing factor in rat arteries. Edwards, G., Dora, K.A., Gardener, M.J., Garland, C.J., Weston, A.H. Nature (1998)
- External Na dependence of ouabain-sensitive ATP:ADP exchange initiated by photolysis of intracellular caged-ATP in human red cell ghosts. Kaplan, J.H., Hollis, R.J. Nature (1980)
- Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Borges, L.F., Elliott, P.J., Gill, R., Iversen, S.D., Iversen, L.L. Science (1985)
- Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Gruber, H.E., Finley, K.D., Hershberg, R.M., Katzman, S.S., Laikind, P.K., Seegmiller, J.E., Friedmann, T., Yee, J.K., Jolly, D.J. Science (1985)
- Ouabain stimulation of noradrenaline transport in guinea pig heart. Sharma, V.K., Pottick, L.A., Banerjee, S.P. Nature (1980)
- Imaging elemental distribution and ion transport in cultured cells with ion microscopy. Chandra, S., Morrison, G.H. Science (1985)
- Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. Kent, R.B., Emanuel, J.R., Ben Neriah, Y., Levenson, R., Housman, D.E. Science (1987)
- Transport defects of rabbit medullary thick ascending limb cells in obstructive nephropathy. Hwang, S.J., Haas, M., Harris, H.W., Silva, P., Yalla, S., Sullivan, M.R., Otuechere, G., Kashgarian, M., Zeidel, M.L. J. Clin. Invest. (1993)
- Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets. Kominato, R., Fujimoto, S., Mukai, E., Nakamura, Y., Nabe, K., Shimodahira, M., Nishi, Y., Funakoshi, S., Seino, Y., Inagaki, N. Diabetologia (2008)
- Partial reversion of the transformed phenotype in HRAS-transfected tumorigenic cells by transfer of a human gene. Schaefer, R., Iyer, J., Iten, E., Nirkko, A.C. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Cardiotonic steroids stimulate glycogen synthesis in human skeletal muscle cells via a Src- and ERK1/2-dependent mechanism. Kotova, O., Al-Khalili, L., Talia, S., Hooke, C., Fedorova, O.V., Bagrov, A.Y., Chibalin, A.V. J. Biol. Chem. (2006)
- Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases. Haas, M., Wang, H., Tian, J., Xie, Z. J. Biol. Chem. (2002)
- Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase. Haas, M., Askari, A., Xie, Z. J. Biol. Chem. (2000)
- Digitalis-induced signaling by Na+/K+-ATPase in human breast cancer cells. Kometiani, P., Liu, L., Askari, A. Mol. Pharmacol. (2005)
- CA2+-free perfusion of rat heart reveals a (Na+ + K+)ATPase form highly sensitive to ouabain. Mansier, P., Lelievre, L.G. Nature (1982)
- Ischemia-induced alterations in myocardial (Na+ + K+)-ATPase and cardiac glycoside binding. Beller, G.A., Conroy, J., Smith, T.W. J. Clin. Invest. (1976)
- Isolation of a sodium transport inhibitory factor, inhibitin, from cultured leukemic promyelocytes. Morgan, K., Mir, M.A. J. Clin. Invest. (1984)
- Role of ouabain-like compound in the rostral ventrolateral medulla in rats. Teruya, H., Yamazato, M., Muratani, H., Sakima, A., Takishita, S., Terano, Y., Fukiyama, K. J. Clin. Invest. (1997)
- Mechanism of enhanced Na-K-ATPase activity in cortical collecting duct from rats with nephrotic syndrome. Féraille, E., Vogt, B., Rousselot, M., Barlet-Bas, C., Cheval, L., Doucet, A., Favre, H. J. Clin. Invest. (1993)