Disease relevance of Oxybuprocaine

• A 40-year-old patient frequently self-administered topical oxybuprocaine drops for approximately 7 days after bilateral ultraviolet-light keratitis [1].
• CONCLUSIONS: Oxybuprocaine may induce a false-positive reaction in an immunochromatographic SAS Adeno Test. We recommend the use of lidocaine, instead of oxybuprocaine, for local anesthesia in taking eye swabs from patients with suspected adenovirus infection [2].
• Bradycardia as a side-effect to oxybuprocaine [3].
• Periorbital allergic contact dermatitis from oxybuprocaine [4].
• Fibrinous iritis due to oxybuprocaine [5].

High impact information on Oxybuprocaine

• The individual ratios between Oxybuprocaine- and saline-instilled eyes in the NIDDM and IDDM patients differed significantly from those in the healthy controls (mean ratios: 2.6, 1.9, and 1.0, respectively; P less than 0.002) [6].
• Oxybuprocaine induces a false-positive response in immunochromatographic SAS Adeno Test [2].
• INTERVENTION: Eyes were randomly assigned to two groups: one group received 0.15 ml intracameral 1% unpreserved lidocaine combined with topical anesthesia (oxybuprocaine); the other group received 6 ml prilocaine peribulbar before phacoemulsification with sclerocorneal tunnel incision [7].
• Abuse of oxybuprocaine appears to produce irreversible damage to the apical cell attachments at the level of the corneal endothelial cells [1].
• The drug treatment protocol comprised topical applications of 0.4% benoxinate, a local anaesthetic (to improve drug absorption), followed either by 0.5% timolol or distilled water (control), either daily (1000 hr) or twice daily (1000, 1600 hr) [8].

Chemical compound and disease context of Oxybuprocaine

• Two weeks before, a corneal ulcer was diagnosed, and oxybuprocaine 0.05% (Lacrimin, Santen, Osaka, Japan) eye drops were prescribed 4 times daily but used every 5 to 10 minutes because the right eye was severely irritated [9].
• The ability to recover from bacterial contaminations with Staphylococcus auresus and Pseudomonas aeruginosa was determined for three optometric DPAs: Fluress, fluorescein and benoxinate [10].
• These data are discussed according to the different mechanisms of action of the three drugs BAK and Oxybuprocaine were found to exert a more direct cell toxicity whereas phenylephrine chloride acted indirectly by causing the sloughing of the cell monolayer [11].

Biological context of Oxybuprocaine

• A rapid and simple spectrophotometric method for benoxinate hydrolysis by human plasma was developed [12].

Anatomical context of Oxybuprocaine

• In Study 2, with healthy volunteers, we compared our previous practice of merely applying three consecutive drops of oxybuprocaine on the conjunctiva before needle insertions to the new technique of placing additional cotton tip sticks soaked in oxybuprocaine on the conjunctiva [13].
• Simultaneous determination of diclofenac and oxybuprocaine in human aqueous humor with HPLC and electrochemical detection [14].
• Apparent respiration rate of the human corneal epithelium with tetracaine HCl and benoxinate HCl [15].
• In human corneas that had been subjected to a period of hypoxia, AEOR was slightly higher after administration of benoxinate, a result in the opposite direction to that expected on the grounds of toxicity [15].

Associations of Oxybuprocaine with other chemical compounds

• PURPOSE:: To evaluate the safety, validity, and comfort of 0.35% fluorexon disodium and 0.4% benoxinate (Flura-Safe) compared with the gold standard of 0.25% sodium fluorescein and 0.4% benoxinate for Goldmann applanation tonometry (GAT) [16].
• The preservatives and the combination OBu + CH increased corneal epithelial permeability significantly (P less than 0.05) [17].
• Using double masking procedures, the response to McKay-Marg and Goldmann tonometry of 361 randomly selected patients was determined following the installation of a single dose of either 0.125, 0.25 or 0.5% proparacaine or 0.1, 0.2 or 0.4% benoxinate [18].
• Furthermore, enzyme activity with benoxinate as substrate is positively correlated (P less than 0.001) with benzoylcholine chloride hydrolysis [12].
• NMR crystallography of oxybuprocaine hydrochloride, Modification II degrees [19].

Gene context of Oxybuprocaine

• Studies on the metabolism of benoxinate by human pseudocholinesterase [12].
• Diclofenac vs oxybuprocaine eyedrops for analgesia in paediatric strabismus surgery [20].

Analytical, diagnostic and therapeutic context of Oxybuprocaine

• Oxybuprocaine and five metabolites simultaneously determined in urine by gas chromatography and gas chromatography-mass spectrometry after extraction with Extrelut [21].
• The positive rate was significantly higher in the oxybuprocaine group compared with those in control groups (P = 0.0062, Fisher's extract probability test) [2].
• A false-positive reaction was observed in six samples (33.3%) in the oxybuprocaine group [2].
• Determination of six metabolites of oxybuprocaine in urine by high-performance liquid chromatography [22].
• It was found that oxybuprocaine reduced the amount of pupil constriction during the operation significantly as compared with the placebo group, facilitating the removal of lens material and the implantation of an intraocular lens [23].

References