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Chemical Compound Review

Aplaviroc HCl     4-[4-[[1-butyl-3-[(R)- cyclohexyl-hydroxy...

Synonyms: AC1MHDOS, AC1OCFQR, AC1LAAV1, AK602, ONO 4128, ...
 
 
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Disease relevance of AK 602

 

High impact information on AK 602

 

Associations of AK 602 with other chemical compounds

 

Gene context of AK 602

References

  1. Structural and Molecular Interactions of CCR5 Inhibitors with CCR5. Maeda, K., Das, D., Ogata-Aoki, H., Nakata, H., Miyakawa, T., Tojo, Y., Norman, R., Takaoka, Y., Ding, J., Arnold, G.F., Arnold, E., Mitsuya, H. J. Biol. Chem. (2006) [Pubmed]
  2. Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model. Nakata, H., Maeda, K., Miyakawa, T., Shibayama, S., Matsuo, M., Takaoka, Y., Ito, M., Koyanagi, Y., Mitsuya, H. J. Virol. (2005) [Pubmed]
  3. Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail. Johnson, B.M., Song, I.H., Adkison, K.K., Borland, J., Fang, L., Lou, Y., Berrey, M.M., Nafziger, A.N., Piscitelli, S.C., Bertino, J.S. Journal of clinical pharmacology. (2006) [Pubmed]
  4. The effects of ritonavir and lopinavir/ritonavir on the pharmacokinetics of a novel CCR5 antagonist, aplaviroc, in healthy subjects. Adkison, K.K., Shachoy-Clark, A., Fang, L., Lou, Y., Otto, V.R., Berrey, M.M., Piscitelli, S.C. British journal of clinical pharmacology. (2006) [Pubmed]
  5. CCR5 antagonists: host-targeted antivirals for the treatment of HIV infection. Westby, M., van der Ryst, E. Antivir. Chem. Chemother. (2005) [Pubmed]
 
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