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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review: 

AC1LACP3     N-[(1S)-4- (diaminomethylideneamino)- 1...

Synonyms: KRH-1636, KRH1636, Krh 1636
 
 
 
 
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Disease relevance of KRH-1636

  • Thus, KRH-1636 seems to be a promising agent for the treatment of HIV-1 infection [1].
 

High impact information on KRH-1636

  • KRH-1636 prevented monoclonal antibodies from binding to CXCR4 without down-modulation of the coreceptor [1].
  • A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity [1].
  • A low molecular weight nonpeptide compound, KRH-1636, efficiently blocked replication of various T cell line-tropic (X4) HIV type 1 (HIV-1) in MT-4 cells and peripheral blood mononuclear cells through the inhibition of viral entry and membrane fusion via the CXC chemokine receptor (CXCR)4 coreceptor but not via CC chemokine receptor 5 [1].

References

  1. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Ichiyama, K., Yokoyama-Kumakura, S., Tanaka, Y., Tanaka, R., Hirose, K., Bannai, K., Edamatsu, T., Yanaka, M., Niitani, Y., Miyano-Kurosaki, N., Takaku, H., Koyanagi, Y., Yamamoto, N. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
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