Chemical Compound Review:
Oltipraz 4-methyl-5-pyrazin-2-yl- dithiole-3-thione
Synonyms:
Oltiprazum, Oltipraz [INN], CHEMBL178459, CCRIS 4048, AG-G-40846, ...
- Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz. O'Dwyer, P.J., Szarka, C.E., Yao, K.S., Halbherr, T.C., Pfeiffer, G.R., Green, F., Gallo, J.M., Brennan, J., Frucht, H., Goosenberg, E.B., Hamilton, T.C., Litwin, S., Balshem, A.M., Engstrom, P.F., Clapper, M.L. J. Clin. Invest. (1996)
- Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Kensler, T.W., Egner, P.A., Wang, J.B., Zhu, Y.R., Zhang, B.C., Lu, P.X., Chen, J.G., Qian, G.S., Kuang, S.Y., Jackson, P.E., Gange, S.J., Jacobson, L.P., Muñoz, A., Groopman, J.D. Gastroenterology (2004)
- Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication. Prochaska, H.J., Yeh, Y., Baron, P., Polsky, B. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Oltipraz may be useful in the prevention or treatment of Alzheimer's disease. Gharibzadeh, S., Hoseini, S.S., Mahdavi, S. Med. Hypotheses (2007)
- Oltipraz treatment in experimental schistosomiasis mansoni. II. Effect of high dose oral therapy on worm load and process of copulation in infected mice. Aboul-Atta, A.M., Hassan, Z.A., el-Ahl, S.S. Journal of the Egyptian Society of Parasitology. (1989)
- Pharmacokinetics of oltipraz after intravenous and oral administration in rats with dehydration for 72 hours. Bae, S.K., Lee, S.J., Kim, J.W., Kim, Y.H., Kim, S.G., Lee, M.G. Biopharmaceutics & drug disposition. (2005)
- Induction of antioxidant genes in the brain as a therapeutic target in bipolar disorder: potential role of oltipraz. Emanuele, E., Olivieri, V., Aldeghi, A., Martinelli, V. Med. Hypotheses (2006)
- Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz. Kang, K.W., Cho, I.J., Lee, C.H., Kim, S.G. J. Natl. Cancer Inst. (2003)
- Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver. Davidson, N.E., Egner, P.A., Kensler, T.W. Cancer Res. (1990)
- Correspondence re: C.V. Rao, et al., Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced lymphoma formation by oltipraz. Cancer Res., 56: 3395-3398, 1996. Roebuck, B.D., Rogers, A.E., Kensler, T.W. Cancer Res. (1997)
- Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Izzotti, A., Balansky, R.M., Dagostini, F., Bennicelli, C., Myers, S.R., Grubbs, C.J., Lubet, R.A., Kelloff, G.J., De Flora, S. Cancer Res. (2001)
- Modulation of glutathione S-transferase alpha by hepatitis B virus and the chemopreventive drug oltipraz. Jaitovitch-Groisman, I., Fotouhi-Ardakani, N., Schecter, R.L., Woo, A., Alaoui-Jamali, M.A., Batist, G. J. Biol. Chem. (2000)
- Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz. Prochaska, H.J., Bornmann, W.G., Baron, P., Polsky, B. Mol. Pharmacol. (1995)
- The chemopreventive agent oltipraz stimulates repair of damaged DNA. O'Dwyer, P.J., Johnson, S.W., Khater, C., Krueger, A., Matsumoto, Y., Hamilton, T.C., Yao, K.S. Cancer Res. (1997)
- Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats. Rao, C.V., Rivenson, A., Katiwalla, M., Kelloff, G.J., Reddy, B.S. Cancer Res. (1993)
- Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention. Buetler, T.M., Bammler, T.K., Hayes, J.D., Eaton, D.L. Cancer Res. (1996)
- Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture. Langouët, S., Coles, B., Morel, F., Becquemont, L., Beaune, P., Guengerich, F.P., Ketterer, B., Guillouzo, A. Cancer Res. (1995)
- Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. Le Ferrec, E., Lagadic-Gossmann, D., Rauch, C., Bardiau, C., Maheo, K., Massiere, F., Le Vee, M., Guillouzo, A., Morel, F. J. Biol. Chem. (2002)
- Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture. Maheo, K., Antras-Ferry, J., Morel, F., Langouët, S., Guillouzo, A. J. Biol. Chem. (1997)
- Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression. Ki, S.H., Cho, I.J., Choi, D.W., Kim, S.G. Mol. Cell. Biol. (2005)
- Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway. Auyeung, D.J., Kessler, F.K., Ritter, J.K. Mol. Pharmacol. (2003)
- Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. Wang, J.S., Shen, X., He, X., Zhu, Y.R., Zhang, B.C., Wang, J.B., Qian, G.S., Kuang, S.Y., Zarba, A., Egner, P.A., Jacobson, L.P., Muñoz, A., Helzlsouer, K.J., Groopman, J.D., Kensler, T.W. J. Natl. Cancer Inst. (1999)
- Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Ramos-Gomez, M., Kwak, M.K., Dolan, P.M., Itoh, K., Yamamoto, M., Talalay, P., Kensler, T.W. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Primiano, T., Egner, P.A., Sutter, T.R., Kelloff, G.J., Roebuck, B.D., Kensler, T.W. Cancer Res. (1995)