Chemical Compound Review:
PERHEXILINE 2-(2,2- dicyclohexylethyl)piperidine
Synonyms:
Perhexilene, Perhexilina, Perhexilinum, perhexilline, CHEMBL75880, ...
Sainte-Marie,
Lafont,
Pécheur,
Favero,
Philippot,
Bienvenüe,
Kennedy,
Kiosoglous,
Murphy,
Pelle,
Horowitz,
Kennedy,
Beck-Oldach,
McFadden-Lewis,
Murphy,
Wong,
Zhang,
Horowitz,
- Perhexiline maleate-induced cirrhosis. Pessayre, D., Bichara, M., Degott, C., Potet, F., Benhamou, J.P., Feldmann, G. Gastroenterology (1979)
- Perhexilene mimicking bronchial carcinoma. Dawkins, K.D., O'Connor, E. Lancet (1978)
- Factors influencing the long-term prognosis of treated patients with variant angina. Waters, D.D., Miller, D.D., Szlachcic, J., Bouchard, A., Méthé, M., Kreeft, J., Théroux, P. Circulation (1983)
- Polyneuropathy with normal metabolism of perhexiline maleate. Jallon, P., Loiseau, P., Orgogozo, J.M., Singlas, E. Ann. Neurol. (1978)
- Activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog. Piris, P., Beaughard, M., Cosnier, D., Labrid, C. Archives internationales de pharmacodynamie et de thérapie. (1978)
- Steatohepatitis-inducing drugs cause mitochondrial dysfunction and lipid peroxidation in rat hepatocytes. Berson, A., De Beco, V., Lettéron, P., Robin, M.A., Moreau, C., El Kahwaji, J., Verthier, N., Feldmann, G., Fromenty, B., Pessayre, D. Gastroenterology (1998)
- Effects of glucagon, histamine, and perhexiline on the ischemic canine mesenteric circulation. Schwaiger, M., Fondacaro, J.D., Jacobson, E.D. Gastroenterology (1979)
- Inhibition by perhexiline of oxidative phosphorylation and the beta-oxidation of fatty acids: possible role in pseudoalcoholic liver lesions. Deschamps, D., DeBeco, V., Fisch, C., Fromenty, B., Guillouzo, A., Pessayre, D. Hepatology (1994)
- The relative sensitization by acidosis of five calcium blockers in cat papillary muscles. Smith, H.J., Briscoe, M.G. J. Mol. Cell. Cardiol. (1985)
- Effect of perhexiline and oxfenicine on myocardial function and metabolism during low-flow ischemia/reperfusion in the isolated rat heart. Kennedy, J.A., Kiosoglous, A.J., Murphy, G.A., Pelle, M.A., Horowitz, J.D. J. Cardiovasc. Pharmacol. (2000)
- Genetically determined differences in drug metabolism as a risk factor in drug toxicity. Eichelbaum, M., Kroemer, H.K., Mikus, G. Toxicol. Lett. (1992)
- Effects of sustained isometric handgrip on ventricular systolic time intervals in patients with ischemic heart disease. Inotropic state of the left ventricle during treatment with perhexiline maleate and with propranolol. Caponnetto, S., Iannetti, M., Pastorini, C., Masperone, M.A., Perugini, P., Oriani, G. Japanese heart journal. (1977)
- Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells. Jaffrézou, J.P., Levade, T., Kuhlein, E., Thurneyssen, O., Chiron, M., Grandjean, H., Carrière, D., Laurent, G. Cancer Res. (1990)
- Reversal of acquired resistance to doxorubicin in P388 murine leukemia cells by perhexiline maleate. Ramu, A., Fuks, Z., Gatt, S., Glaubiger, D. Cancer Res. (1984)
- Perhexiline-induced lipidosis in the dark Agouti (DA) rat. An animal model of genetically determined neurotoxicity. Meier, C., Wahllaender, A., Hess, C.W., Preisig, R. Brain (1986)
- Impaired oxidation of debrisoquine in patients with perhexiline liver injury. Morgan, M.Y., Reshef, R., Shah, R.R., Oates, N.S., Smith, R.L., Sherlock, S. Gut (1984)
- Perhexiline during exercise training in coronary heart disease. Teo, K.K., Kelly, J.G., Darby, J.F., Ennis, J.T., Horgan, J.H. Clin. Pharmacol. Ther. (1983)
- Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide. Willoughby, S.R., Stewart, S., Chirkov, Y.Y., Kennedy, J.A., Holmes, A.S., Horowitz, J.D. Eur. Heart J. (2002)
- Effects of perhexiline on survival time and infarct size in experimental myocardial infarction. Daniell, H.B., Privitera, P.J., Conradi, S.E., Gaffney, T.E. J. Pharmacol. Exp. Ther. (1977)
- The effects of perhexiline on the sympathetic nervous system. Daniell, H.B., Saelens, D.A., Webb, J.G. J. Pharmacol. Exp. Ther. (1979)
- Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent. Cole, P.L., Beamer, A.D., McGowan, N., Cantillon, C.O., Benfell, K., Kelly, R.A., Hartley, L.H., Smith, T.W., Antman, E.M. Circulation (1990)
- Polymorphic hydroxylation of perhexiline maleate in man. Cooper, R.G., Evans, D.A., Whibley, E.J. J. Med. Genet. (1984)
- The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes. Elferink, J.G., Deierkauf, M. Biochem. Pharmacol. (1984)
- CYP2B6, CYP2D6, and CYP3A4 Catalyze the Primary Oxidative Metabolism of Perhexiline Enantiomers by Human Liver Microsomes. Davies, B.J., Coller, J.K., Somogyi, A.A., Milne, R.W., Sallustio, B.C. Drug Metab. Dispos. (2007)
- Transferrin receptor functions as a signal-transduction molecule for its own recycling via increases in the internal Ca2+ concentration. Sainte-Marie, J., Lafont, V., Pécheur, E.I., Favero, J., Philippot, J.R., Bienvenüe, A. Eur. J. Biochem. (1997)
- The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase. An, D., Pulinilkunnil, T., Qi, D., Ghosh, S., Abrahani, A., Rodrigues, B. Am. J. Physiol. Endocrinol. Metab. (2005)
- Effect of the anti-anginal agent, perhexiline, on neutrophil, valvular and vascular superoxide formation. Kennedy, J.A., Beck-Oldach, K., McFadden-Lewis, K., Murphy, G.A., Wong, Y.W., Zhang, Y., Horowitz, J.D. Eur. J. Pharmacol. (2006)
- Stable angina and acute coronary syndromes are associated with nitric oxide resistance in platelets. Chirkov, Y.Y., Holmes, A.S., Willoughby, S.R., Stewart, S., Wuttke, R.D., Sage, P.R., Horowitz, J.D. J. Am. Coll. Cardiol. (2001)
- Electrophysiologic properties of perhexiline. Vera, Z., Gray, D.R., Harter, K.W., Janzen, D.A., Massumi, R.A., Mason, D.T. Clin. Pharmacol. Ther. (1975)