Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LA3QT [[[4-(2-amino-6-oxo-3H-purin- 9-yl)-2...

Synonyms: (R,S)-PCV-TP, Penciclovir triphosphate, KGSIOVLUJYQLKR-UHFFFAOYSA-N, 02D9CF82CEC9014C48DBDA70254BB1E7

Shaw, T. et al., Vere Hodge, R.A. et al., Crumpacker, C.

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Disease relevance of AIDS-169945

Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir [1].
The absolute configuration of penciclovir-triphosphate (PCV-TP) produced in HSV-1 infected cells was shown to be S with an enantiomeric purity of greater than 95% [2].

High impact information on AIDS-169945

Similar to acyclovir, famciclovir is converted by phosphorylation to its active metabolite, penciclovir-triphosphate [3].

References

Inhibition of hepatitis B virus DNA polymerase by enantiomers of penciclovir triphosphate and metabolic basis for selective inhibition of HBV replication by penciclovir. Shaw, T., Mok, S.S., Locarnini, S.A. Hepatology (1996) [Pubmed]
Use of isotopically chiral [4'-13C]penciclovir and 13C NMR to determine the specificity and absolute configuration of penciclovir phosphate esters formed in HSV-1 and HSV-2 infected cells and by HSV-1-encoded thymidine kinase. Vere Hodge, R.A., Darlison, S.J., Earnshaw, D.L., Readshaw, S.A. Chirality. (1993) [Pubmed]
The pharmacological profile of famciclovir. Crumpacker, C. Seminars in dermatology. (1996) [Pubmed]

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