Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Manderol ethyl3-(3,5-dichlorophenyl)- 5-methyl-2,4...

Synonyms: Serinal, CHLOZOLINATE, Dichlozolinate, LS-100253, BRN 1156137, ...

Takamune, N. et al., Gray, L.E. et al.

Gray, Wolf, Lambright, Mann, Price, Cooper, Ostby,

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Disease relevance of M 8164

Chlozolinate and iprodione did not produce any signs of maternal or fetal endocrine toxicity at 100 mg kg-1 day-1 [1].
Six serinal derivatives were synthesized and tested for their anti-human immunodeficiency virus type-1 (HIV-1) activity against HIV-1-infected cells [2].

High impact information on M 8164

Of the 6 serinal derivatives tested, only N,O-didecanoyl serinal dimethylacetal (DDSD) was found to strongly suppress progeny virus production from acute HIV-1-infected CEM cells, while not suppressing the HIV-1 p24 production from latent HIV-1-infected ACH-2 cells after stimulation with phorbol 12-myristate 13-acetate [2].

References

Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Gray, L.E., Wolf, C., Lambright, C., Mann, P., Price, M., Cooper, R.L., Ostby, J. Toxicology and industrial health. (1999) [Pubmed]
Blockage of HIV-1 production through inhibition of proviral DNA synthesis by N,O-didecanoyl serinal dimethylacetal. Takamune, N., Misumi, S., Furuishi, K., Shoji, S. IUBMB Life (1999) [Pubmed]

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