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Chemical Compound Review

dinoprost     (Z)-7-[(1R,2S,3R,5S)-3,5- dihydroxy-2-[(E...

Synonyms: cyclosin, Enzaprost F, PGF2, PGF2alpha, PGF2 alpha, ...
 
 
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Disease relevance of Enzaprost F

 

Psychiatry related information on Enzaprost F

 

High impact information on Enzaprost F

 

Chemical compound and disease context of Enzaprost F

 

Biological context of Enzaprost F

 

Anatomical context of Enzaprost F

 

Associations of Enzaprost F with other chemical compounds

  • In many nonprimate mammalian species, cyclical regression of the corpus luteum (luteolysis) is caused by the episodic pulsatile secretion of uterine PGF2alpha, which acts either locally on the corpus luteum by a countercurrent mechanism or, in some species, via the systemic circulation [11].
  • Endogenous phospholipase A2 activity of brain synaptic vesicles was Ca2+ -dependent and was increased by prostaglandin F2 alpha, calmodulin, adenosine 3', 5' -monophosphate, and adenosine triphosphate, whereas the activity was inhibited by prostaglandin E2 in the absence or presence of calmodulin [26].
  • None of the stable cyclooxygenase products of 20:4 (6-keto PGF1 alpha, PGF2 alpha, PGE2, TXB2) nor polar metabolites of mono-HETEs are either incorporated or metabolized [27].
  • In this study the airways effects of 9 alpha,11 beta-PGF2 were compared with those of its epimer 9 alpha,11 alpha-PGF2 (PGF2 alpha) and PGD2 [28].
  • Keratinocyte cultures incubated with [14C]arachidonic acid synthesized prostaglandin (PG)E2 PGD2, PGF2 alpha, and small quantities of 6-keto-F1 alpha [29].
 

Gene context of Enzaprost F

  • Measurement of uterine PGs further confirmed that COX-1 accounted for the majority of PGF2alpha production [30].
  • In contrast, simultaneous oxytocin and COX-1 deficiency restored the normal onset of labor by allowing luteolysis in the absence of elevated PGF2alpha production [30].
  • Finally, we confirmed that PGF2alpha could potentiate angiogenesis in endometrial adenocarcinoma explants by transactivation of the EGFR and induction of VEGF mRNA expression [31].
  • The binding was displaced with unlabeled PGs in the order of PGF2 alpha = 9 alpha, 11 beta PGF2 > PGF 1 alpha > PGD2 > STA2 (a stable TXA2 agonist) > PGE2 > iloprost (a stable PGI2 agonist) [32].
  • LIF and OSM specifically trigger STAT1 cytoplasmic to nuclear translocation, whereas PGF2alpha fails to do so [33].
  • We show that PGF2alpha increases expression of the inhibitor of apoptosis protein (IAP) BRUCE through a pathway dependent on the nuclear factor of activated T cell 2 transcription factor [34].
 

Analytical, diagnostic and therapeutic context of Enzaprost F

References

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