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Chemical Compound Review

Accutane     (2Z,4E,6E,8E)-3,7-dimethyl-9- (2,6,6...

Synonyms: Roaccutane, Isotretinoin, Ro 43780, Ro 4 3780, Ro 4-3780, ...
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Disease relevance of Retinoic acid


High impact information on Retinoic acid


Chemical compound and disease context of Retinoic acid


Biological context of Retinoic acid


Anatomical context of Retinoic acid


Associations of Retinoic acid with other chemical compounds


Gene context of Retinoic acid


Analytical, diagnostic and therapeutic context of Retinoic acid


  1. Treatment of high-risk neuroblastoma with intensive chemotherapy, radiotherapy, autologous bone marrow transplantation, and 13-cis-retinoic acid. Children's Cancer Group. Matthay, K.K., Villablanca, J.G., Seeger, R.C., Stram, D.O., Harris, R.E., Ramsay, N.K., Swift, P., Shimada, H., Black, C.T., Brodeur, G.M., Gerbing, R.B., Reynolds, C.P. N. Engl. J. Med. (1999) [Pubmed]
  2. Retinoid hyperostosis. Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory ichthyosis. Pittsley, R.A., Yoder, F.W. N. Engl. J. Med. (1983) [Pubmed]
  3. 13-cis-retinoic acid in the treatment of oral leukoplakia. Hong, W.K., Endicott, J., Itri, L.M., Doos, W., Batsakis, J.G., Bell, R., Fofonoff, S., Byers, R., Atkinson, E.N., Vaughan, C. N. Engl. J. Med. (1986) [Pubmed]
  4. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. Castleberry, R.P., Emanuel, P.D., Zuckerman, K.S., Cohn, S., Strauss, L., Byrd, R.L., Homans, A., Chaffee, S., Nitschke, R., Gualtieri, R.J. N. Engl. J. Med. (1994) [Pubmed]
  5. Treatment of keratoacanthomas with oral 13-cis-retinoic acid. Haydey, R.P., Reed, M.L., Dzubow, L.M., Shupack, J.L. N. Engl. J. Med. (1980) [Pubmed]
  6. Prolonged remissions of cystic and conglobate acne with 13-cis-retinoic acid. Peck, G.L., Olsen, T.G., Yoder, F.W., Strauss, J.S., Downing, D.T., Pandya, M., Butkus, D., Arnaud-Battandier, J. N. Engl. J. Med. (1979) [Pubmed]
  7. Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Brinckerhoff, C.E., Coffey, J.W., Sullivan, A.C. Science (1983) [Pubmed]
  8. Modulation of procollagen gene expression by retinoids. Inhibition of collagen production by retinoic acid accompanied by reduced type I procollagen messenger ribonucleic acid levels in human skin fibroblast cultures. Oikarinen, H., Oikarinen, A.I., Tan, E.M., Abergel, R.P., Meeker, C.A., Chu, M.L., Prockop, D.J., Uitto, J. J. Clin. Invest. (1985) [Pubmed]
  9. Combined interferon-alfa, 13-cis-retinoic acid, and alpha-tocopherol in locally advanced head and neck squamous cell carcinoma: novel bioadjuvant phase II trial. Shin, D.M., Khuri, F.R., Murphy, B., Garden, A.S., Clayman, G., Francisco, M., Liu, D., Glisson, B.S., Ginsberg, L., Papadimitrakopoulou, V., Myers, J., Morrison, W., Gillenwater, A., Ang, K.K., Lippman, S.M., Goepfert, H., Hong, W.K. J. Clin. Oncol. (2001) [Pubmed]
  10. In vitro hemopoiesis of marrow cells from myelodysplastic patients: effects of mitogen-stimulated spleen cell-conditioned medium and vitamin A and D derivatives. Fabian, I., Riklis, I., Tatarsky, I., Nagler, A. Cancer Res. (1986) [Pubmed]
  11. Phase II evaluation of temozolomide and 13-cis-retinoic acid for the treatment of recurrent and progressive malignant glioma: a North American Brain Tumor Consortium study. Jaeckle, K.A., Hess, K.R., Yung, W.K., Greenberg, H., Fine, H., Schiff, D., Pollack, I.F., Kuhn, J., Fink, K., Mehta, M., Cloughesy, T., Nicholas, M.K., Chang, S., Prados, M. J. Clin. Oncol. (2003) [Pubmed]
  12. Pharmacokinetics and effects on plasma retinol concentrations of 13-cis-retinoic acid in melanoma patients. Formelli, F., Cavadini, E., Mascheroni, L., Belli, F., Cascinelli, N. Br. J. Cancer (1997) [Pubmed]
  13. Modulation of the metastatic phenotype by 13-cis-retinoic acid. Couch, M.J., Pauli, B.U., Weinstein, R.S., Coon, J.S. J. Natl. Cancer Inst. (1987) [Pubmed]
  14. 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice. Crandall, J., Sakai, Y., Zhang, J., Koul, O., Mineur, Y., Crusio, W.E., McCaffery, P. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  15. Disappearance of cytogenetic abnormalities and clinical remission during therapy with 13-cis-retinoic acid in a patient with myelodysplastic syndrome: inhibition of growth of the patient's malignant monocytoid clone. Abrahm, J., Besa, E.C., Hyzinski, M., Finan, J., Nowell, P. Blood (1986) [Pubmed]
  16. Pharmacokinetics of 13-cis-retinoic acid in patients with advanced cancer. Goodman, G.E., Einspahr, J.G., Alberts, D.S., Davis, T.P., Leigh, S.A., Chen, H.S., Meyskens, F.L. Cancer Res. (1982) [Pubmed]
  17. 13-cis-retinoic acid plus interferon-alpha 2a in locally advanced squamous cell carcinoma of the cervix. Lippman, S.M., Kavanagh, J.J., Paredes-Espinoza, M., Delgadillo-Madrueño, F., Paredes-Casillas, P., Hong, W.K., Massimini, G., Holdener, E.E., Krakoff, I.H. J. Natl. Cancer Inst. (1993) [Pubmed]
  18. Phase I trial of 13-cis-retinoic acid in children with neuroblastoma following bone marrow transplantation. Villablanca, J.G., Khan, A.A., Avramis, V.I., Seeger, R.C., Matthay, K.K., Ramsay, N.K., Reynolds, C.P. J. Clin. Oncol. (1995) [Pubmed]
  19. Role of intracellular redox status in apoptosis induction of human T-cell leukemia virus type I-infected lymphocytes by 13-cis-retinoic acid. Furuke, K., Sasada, T., Ueda-Taniguchi, Y., Yamauchi, A., Inamoto, T., Yamaoka, Y., Masutani, H., Yodoi, J. Cancer Res. (1997) [Pubmed]
  20. Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid. Squire, R.A., Sporn, M.B., Brown, C.C., Smith, J.M., Wenk, M.L., Springer, S. Cancer Res. (1977) [Pubmed]
  21. 13-cis-retinoic acid: inhibition of bladder carcinogenesis in the rat. Sporn, M.B., Squire, R.A., Brown, C.C., Smith, J.M., Wenk, M.L., Springer, S. Science (1977) [Pubmed]
  22. Analysis and stability of retinol in plasma. Peng, Y.M., Xu, M.J., Alberts, D.S. J. Natl. Cancer Inst. (1987) [Pubmed]
  23. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. Izzo, J.G., Papadimitrakopoulou, V.A., Liu, D.D., den Hollander, P.L., Babenko, I.M., Keck, J., El-Naggar, A.K., Shin, D.M., Lee, J.J., Hong, W.K., Hittelman, W.N. J. Natl. Cancer Inst. (2003) [Pubmed]
  24. Effects of retinoids on metabolizing enzymes and on binding of benzo(a)pyrene to rat tissue DNA. McCarthy, D.J., Lindamood, C., Hill, D.L. Cancer Res. (1987) [Pubmed]
  25. Expression of retinoic acid receptor beta in human renal cell carcinomas correlates with sensitivity to the antiproliferative effects of 13-cis-retinoic acid. Hoffman, A.D., Engelstein, D., Bogenrieder, T., Papandreou, C.N., Steckelman, E., Dave, A., Motzer, R.J., Dmitrovsky, E., Albino, A.P., Nanus, D.M. Clin. Cancer Res. (1996) [Pubmed]
  26. Retinoids synergize with interleukin-2 to augment IFN-gamma and interleukin-12 production by human peripheral blood mononuclear cells. Fox, F.E., Kubin, M., Cassin, M., Niu, Z., Trinchieri, G., Cooper, K.D., Rook, A.H. J. Interferon Cytokine Res. (1999) [Pubmed]
  27. Interaction of retinoic acid and interferon in renal cancer cell lines. Nanus, D.M., Geng, Y., Shen, R., Lai, H.K., Pfeffer, S.R., Pfeffer, L.M. J. Interferon Cytokine Res. (2000) [Pubmed]
  28. A second CYP26 P450 in humans and zebrafish: CYP26B1. Nelson, D.R. Arch. Biochem. Biophys. (1999) [Pubmed]
  29. Phase II trial of 13-cis-retinoic acid plus interferon alpha in non-small-cell lung cancer. The National Cancer Institute of Canada Clinical Trials Group. Arnold, A., Ayoub, J., Douglas, L., Hoogendoorn, P., Skingley, L., Gelmon, K., Hirsh, V., Eisenhauer, E. J. Natl. Cancer Inst. (1994) [Pubmed]
  30. Nuclear retinoid acid receptor beta in bronchial epithelium of smokers before and during chemoprevention. Xu, X.C., Lee, J.S., Lee, J.J., Morice, R.C., Liu, X., Lippman, S.M., Hong, W.K., Lotan, R. J. Natl. Cancer Inst. (1999) [Pubmed]
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