Chemical Compound Review:
AC1NRBJE (2R)-N'-hydroxy-N-[(1S)-2- (5H-indol-3-yl)...
Synonyms:
- Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. Balakrishnan, A., Patel, B., Sieber, S.A., Chen, D., Pachikara, N., Zhong, G., Cravatt, B.F., Fan, H. J. Biol. Chem. (2006)
- Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1. McLaughlin, J.N., Shen, L., Holinstat, M., Brooks, J.D., Dibenedetto, E., Hamm, H.E. J. Biol. Chem. (2005)
- Arterial repair after stenting and the effects of GM6001, a matrix metalloproteinase inhibitor. Li, C., Cantor, W.J., Nili, N., Robinson, R., Fenkell, L., Tran, Y.L., Whittingham, H.A., Tsui, W., Cheema, A.N., Sparkes, J.D., Pritzker, K., Levy, D.E., Strauss, B.H. J. Am. Coll. Cardiol. (2002)
- Synthetic matrix metalloproteinase inhibitors inhibit growth of established breast cancer osteolytic lesions and prolong survival in mice. Winding, B., NicAmhlaoibh, R., Misander, H., Høegh-Andersen, P., Andersen, T.L., Holst-Hansen, C., Heegaard, A.M., Foged, N.T., Brünner, N., Delaissé, J.M. Clin. Cancer Res. (2002)
- Society of Biomaterials Graduate Degree Candidate Student Research Award. Matrix metalloproteinase inhibitor within an absorbable coating for vascular applications: delivery device characterization and reduction of smooth muscle cell proliferation and migration. Caldwell, R.A., Vyavahare, N., Langan, E.M., LaBerge, M. Journal of biomedical materials research. Part A. (2003)
- Cortical spreading depression activates and upregulates MMP-9. Gursoy-Ozdemir, Y., Qiu, J., Matsuoka, N., Bolay, H., Bermpohl, D., Jin, H., Wang, X., Rosenberg, G.A., Lo, E.H., Moskowitz, M.A. J. Clin. Invest. (2004)
- Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. Jones, P.L., Crack, J., Rabinovitch, M. J. Cell Biol. (1997)
- Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum. Budagian, V., Bulanova, E., Orinska, Z., Duitman, E., Brandt, K., Ludwig, A., Hartmann, D., Lemke, G., Saftig, P., Bulfone-Paus, S. Mol. Cell. Biol. (2005)
- In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases. Strauss, B.H., Robinson, R., Batchelor, W.B., Chisholm, R.J., Ravi, G., Natarajan, M.K., Logan, R.A., Mehta, S.R., Levy, D.E., Ezrin, A.M., Keeley, F.W. Circ. Res. (1996)
- E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Margulis, A., Zhang, W., Alt-Holland, A., Crawford, H.C., Fusenig, N.E., Garlick, J.A. Cancer Res. (2005)
- Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases. Zhao, Y., He, D., Saatian, B., Watkins, T., Spannhake, E.W., Pyne, N.J., Natarajan, V. J. Biol. Chem. (2006)
- Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis. Karsdal, M.A., Larsen, L., Engsig, M.T., Lou, H., Ferreras, M., Lochter, A., Delaissé, J.M., Foged, N.T. J. Biol. Chem. (2002)
- Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor. Buteau, J., Foisy, S., Joly, E., Prentki, M. Diabetes (2003)
- Proximal events in signaling by plasma membrane estrogen receptors. Razandi, M., Pedram, A., Park, S.T., Levin, E.R. J. Biol. Chem. (2003)
- Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Si-Tayeb, K., Monvoisin, A., Mazzocco, C., Lepreux, S., Decossas, M., Cubel, G., Taras, D., Blanc, J.F., Robinson, D.R., Rosenbaum, J. Am. J. Pathol. (2006)
- Transforming growth factor-beta-induced osteoblast elongation regulates osteoclastic bone resorption through a p38 mitogen-activated protein kinase- and matrix metalloproteinase-dependent pathway. Karsdal, M.A., Fjording, M.S., Foged, N.T., Delaissé, J.M., Lochter, A. J. Biol. Chem. (2001)
- Matrix metalloproteinase inhibitors suppress transforming growth factor-beta-induced subcapsular cataract formation. Dwivedi, D.J., Pino, G., Banh, A., Nathu, Z., Howchin, D., Margetts, P., Sivak, J.G., West-Mays, J.A. Am. J. Pathol. (2006)
- T cell gelatinases mediate basement membrane transmigration in vitro. Leppert, D., Waubant, E., Galardy, R., Bunnett, N.W., Hauser, S.L. J. Immunol. (1995)
- Transmigration: a new property of mature multinucleated osteoclasts. Saltel, F., Chabadel, A., Zhao, Y., Lafage-Proust, M.H., Cl??zardin, P., Jurdic, P., Bonnelye, E. J. Bone Miner. Res. (2006)
- Mutation analysis of membrane type-1 matrix metalloproteinase (MT1-MMP). The role of the cytoplasmic tail Cys(574), the active site Glu(240), and furin cleavage motifs in oligomerization, processing, and self-proteolysis of MT1-MMP expressed in breast carcinoma cells. Rozanov, D.V., Deryugina, E.I., Ratnikov, B.I., Monosov, E.Z., Marchenko, G.N., Quigley, J.P., Strongin, A.Y. J. Biol. Chem. (2001)
- Angiotensin II activates matrix metalloproteinase type II and mimics age-associated carotid arterial remodeling in young rats. Wang, M., Zhang, J., Spinetti, G., Jiang, L.Q., Monticone, R., Zhao, D., Cheng, L., Krawczyk, M., Talan, M., Pintus, G., Lakatta, E.G. Am. J. Pathol. (2005)
- Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis. Michaelis, U.R., Fisslthaler, B., Barbosa-Sicard, E., Falck, J.R., Fleming, I., Busse, R. J. Cell. Sci. (2005)
- Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37. Schmidtchen, A., Frick, I.M., Andersson, E., Tapper, H., Björck, L. Mol. Microbiol. (2002)
- TIMP-1 inhibits microvascular endothelial cell migration by MMP-dependent and MMP-independent mechanisms. Akahane, T., Akahane, M., Shah, A., Connor, C.M., Thorgeirsson, U.P. Exp. Cell Res. (2004)
- Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis. Deryugina, E.I., Soroceanu, L., Strongin, A.Y. Cancer Res. (2002)
- Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V. Rabie, T., Strehl, A., Ludwig, A., Nieswandt, B. J. Biol. Chem. (2005)
- ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells. Hakulinen, J., Keski-Oja, J. J. Biol. Chem. (2006)
- Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Kong, Y., Poon, R., Nadesan, P., Di Muccio, T., Fodde, R., Khokha, R., Alman, B.A. Cancer Res. (2004)
- Matrix metalloproteinase(s) mediate(s) NO-induced dissociation of beta-catenin from membrane bound E-cadherin and formation of nuclear beta-catenin/LEF-1 complex. Mei, J.M., Borchert, G.L., Donald, S.P., Phang, J.M. Carcinogenesis (2002)
- Administration of a matrix metalloproteinase inhibitor after hemorrhage improves cardiovascular and hepatocellular function. Wang, P., Ba, Z.F., Galardy, R.E., Chaudry, I.H. Shock (1996)