Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AC1NSK18 N-[(4- dimethylaminophenyl)methyl]- 7...

Synonyms: W-54011, 405098-33-1, MolPort-009-199-141, C5a Receptor Antagonist, W-54011

This record was replaced with 5311122.

Sumichika, H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

In gerbils, oral administration of W-54011 (3-30 mg/kg) inhibited C5a-induced neutropenia in a dose-dependent manner [1].

High impact information on N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

W-54011 inhibited the binding of (125)I-labeled C5a to human neutrophils with a K(i) value of 2.2 nm [1].

Biological context of N-[(4-dimethylaminophenyl)methyl]-7-methoxy-N-p-cumenyl-tetralin-1-carboxamide

Examination on the species specificity of W-54011 revealed that it was able to inhibit C5a-induced intracellular Ca(2+) mobilization in neutrophils of cynomolgus monkeys and gerbils but not mice, rats, guinea pigs, rabbits, and dogs [1].

References

Identification of a potent and orally active non-peptide C5a receptor antagonist. Sumichika, H., Sakata, K., Sato, N., Takeshita, S., Ishibuchi, S., Nakamura, M., Kamahori, T., Ehara, S., Itoh, K., Ohtsuka, T., Ohbora, T., Mishina, T., Komatsu, H., Naka, Y. J. Biol. Chem. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use

[search][advanced]