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Chemical Compound Review

AC1NS0GT     4-[5-[6-(4-methylpyrazin-1- yl)-1H...

Synonyms:
 
 
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Disease relevance of HOECHST 33258

 

High impact information on HOECHST 33258

  • Use of the bisbenzimidazole dye, Hoechst 33258, for chromosome staining after gentle fixation made possible the rapid identification and correlation of mitotic phase with surface properties [6].
  • Apoptosis was measured by two methods: 1) quantitative fluorescence microscopy of nuclear chromatin condensation in cells stained with the dye, bisbenzamide trihydrochloride (Hoechst-33258), and 2) terminal deoxynucleotidyl transferase (TdT) labeling of the 3'-OH ends of DNA fragments produced in apoptotic cells [7].
  • METHODS: Morphological changes were shown by light and electron microscopy, chromatin condensation and DNA breaks were assessed using Hoechst 33258 staining and DNA nickend labeling, and DNA fragmentation was characterized b gel electrophoresis [8].
  • The DNA-binding fluorophore Hoechst 33258 revealed chromatin condensation patterns consistent with apoptotic cell death in all cell types except MCF-7 cells [9].
  • The S6 peptide is shown to be a competitive inhibitor of Hoechst 33258, and it is concluded that the SPKK repeat binds to DNA in its minor groove with a binding constant, KS6 = 1.67 X 10(10) M-1 [10].
 

Chemical compound and disease context of HOECHST 33258

 

Biological context of HOECHST 33258

 

Anatomical context of HOECHST 33258

 

Associations of HOECHST 33258 with other chemical compounds

 

Gene context of HOECHST 33258

 

Analytical, diagnostic and therapeutic context of HOECHST 33258

References

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