The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AC1NUSSQ     (8S,9S,10R,13S,14S)-17- hydroxy-17-(2...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cortisone


Psychiatry related information on cortisone

  • In the social phobia study, cortisone (25 mg) administered orally 1 h before a socio-evaluative stressor significantly reduced self-reported fear during the anticipation, exposure, and recovery phase of the stressor [6].
  • Alteration of the critical period for induction of persistent oestrus by early postnatal treatment with gonadal steroids in neonatally cortisone-primed mice [7].
  • Cortisone cure of the lidgap defect in fetal mice: a dose-response and time-response study [8].
  • Both the psychotic disorder and peripheral involvement responded to cortisone [9].
  • For some patients with mild, near-to-asymptomatic disease, glucocorticoid replacement therapy may not be required except during stressful events; for symptomatic patients, replacement doses i.e., mean daily dose 20 mg (0.30 mg/kg) hydrocortisone or 25 mg (0.35 mg/kg) cortisone acetate, are usually sufficient [10].

High impact information on cortisone

  • A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes [11].
  • To detect abnormalities in the secretion of insulin and growth hormone in monozygotic twin siblings of patients with juvenile-onset diabetes, their responses during oral, cortisone-primed oral, and intravenous, glucose tolerance tests and intravenous tolbutamide tests were compared to those of matched controls [12].
  • Sex difference in ontogenesis of circadian adrenocortical rhythm in cortisone-primed rats [13].
  • Of all the heparin fragments tested, the most potent inhibition of angiogenesis in the presence of cortisone was provided by a hexasaccharide with a molecular weight of about 1600 [14].
  • As T lymphocytes "mature" in immunologic function--from thymocytes to cortisone-resistant thymocytes to splenic T lymphocytes--their response to histamine increases [15].

Chemical compound and disease context of cortisone


Biological context of cortisone

  • The kinetics of their appearance and disappearance in adult thymectomized mice, the rapid chasing of BrdU from labeled cells, and their in vivo cortisone sensitivity all suggest CD8lo cells are slated for deletion [21].
  • The surface phenotypes and differentiative history of specific helper-effector (HE) and specific feedback suppression-inducer (FBSI) cell sets were further defined in reference to the Qa-1 and I-J marker systems by culture of selected sets of cortisone-resistant nylon-purified thymocytes with antigen on primed macrophages [22].
  • However, DNA replication was induced in cortisone-resistant thymocytes by lymphocytosis-promoting factor (LPF) [23].
  • Our data are consistent with MCF virus-induced transformation of cells in the lineage to small peanut agglutinin-positive, cortisone-sensitive thymocytes, a subpopulation that predominates in the thymus and which is thought to be destined for cell death in situ [24].
  • Pregnant rats were administered cortisone acetate, 20 mg/100 g of body weight, or normal saline by daily IP injection from day 18-21 of gestation [25].

Anatomical context of cortisone

  • In an attempt to modulate the recognition processes that occur on lymphocyte membranes in mixed lymphocyte culture, responding cortisone resistant thymocytes or stimulating spleen cells (treated with mitomycin C) were pretreated with native concanavalin A (N-Con A) or succinyl-Con A (S-Con A) [26].
  • 5--10% of the thymus cells, 20--30% of cortisone-resistant thymus cells, 60--70% of lymph node cells, and 60--80% of ATC-spleen and T.TDL showed Ia [27].
  • The cultured TdT+ cells are antigenically "null" cells that further resemble their normal counterparts in bone marrow with respect to morphology, size, cortisone sensitivity, and pattern of TdT fluorescence [28].
  • In addition, spleen cells from mice treated with cortisone made the resistant C3H macrophages 100 times more susceptible in vitro [3].
  • Unprimed, cortisone-resistant, nylon wool-purified thymocytes cultured with adherent peritoneal exudate cells can be primed in vitro with soluble carrier protein to generate carrier-reactive helper cells [29].

Associations of cortisone with other chemical compounds


Gene context of cortisone


Analytical, diagnostic and therapeutic context of cortisone

  • In a small number of animals treated with cortisone or cortisone and IgG and in 6/20 animals treated with cortisone and tolerogen, minimal lesions as judged by light, fluorescent, and electron microscopy were found [39].
  • Splenectomy or high-dose cortisone treatment had no effect on the shorter survival of PIGA- RBCs [40].
  • These studies suggested that, while clearance of inert particulate matter and of antibody-coated RBC from the blood occurred primarily by a cortisone-suppressible, presumably phagocytic process in the spleen, chemically altered RBC were removed primarily by a cortisone-insensitive filtration process in the splenic microvasculature [41].
  • However, a 2-week course of immunosuppression with antilymphocyte serum and cortisone acetate results in reactivation and dissemination of the latent virus in all animals [42].
  • A greater than 50% reduction in circulating lymphocytes was observed 4 hr after injection of soluble hydrocortisone and 24 hr after daily subcutaneous injections of depot cortisone acetate [43].


  1. Hyperandrogenism in polycystic ovary syndrome. Evidence of dysregulation of 11 beta-hydroxysteroid dehydrogenase. Rodin, A., Thakkar, H., Taylor, N., Clayton, R. N. Engl. J. Med. (1994) [Pubmed]
  2. Urine free-cortisol determination. A useful tool in the management of chronic hypoadrenal states. Burch, W.M. JAMA (1982) [Pubmed]
  3. In vitro macrophage manifestation of cortisone-induced decrease in resistance to mouse hepatitis virus. Taylor, C.E., Weiser, W.Y., Bang, F.B. J. Exp. Med. (1981) [Pubmed]
  4. Hamster female protein. A divergent acute phase protein in male and female Syrian hamsters. Coe, J.E., Ross, M.J. J. Exp. Med. (1983) [Pubmed]
  5. Syndrome of apparent mineralocorticoid excess. A defect in the cortisol-cortisone shuttle. Stewart, P.M., Corrie, J.E., Shackleton, C.H., Edwards, C.R. J. Clin. Invest. (1988) [Pubmed]
  6. Glucocorticoids reduce phobic fear in humans. Soravia, L.M., Heinrichs, M., Aerni, A., Maroni, C., Schelling, G., Ehlert, U., Roozendaal, B., de Quervain, D.J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Alteration of the critical period for induction of persistent oestrus by early postnatal treatment with gonadal steroids in neonatally cortisone-primed mice. Takasugi, N., Tomooka, Y. J. Endocrinol. (1976) [Pubmed]
  8. Cortisone cure of the lidgap defect in fetal mice: a dose-response and time-response study. Harris, M.J., Juriloff, D.M., Biddle, F.G. Teratology (1984) [Pubmed]
  9. Psychotic episodes in an elderly woman with an anticentromere-positive scleroderma variant, IgA deficiency, and hypothyroidism. Schmid, A.H., Meltzer, B.R. Journal of geriatric psychiatry and neurology. (1994) [Pubmed]
  10. Isolated corticotrophin deficiency. Andrioli, M., Giraldi, F.P., Cavagnini, F. Pituitary (2006) [Pubmed]
  11. A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. Reichert, R.A., Gallatin, W.M., Butcher, E.C., Weissman, I.L. Cell (1984) [Pubmed]
  12. Serum insulin and growth hormone response patterns in monozygotic twin siblings of patients with juvenile-onset diabetes. Johansen, K., Soeldner, J.S., Gleason, R.E., Gottlieb, M.S., Park, B.N., Kaufmann, R.L., Tan, M.H. N. Engl. J. Med. (1975) [Pubmed]
  13. Sex difference in ontogenesis of circadian adrenocortical rhythm in cortisone-primed rats. Miyabo, S., Hisada, T. Nature (1975) [Pubmed]
  14. Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone. Folkman, J., Langer, R., Linhardt, R.J., Haudenschild, C., Taylor, S. Science (1983) [Pubmed]
  15. Selective display of histamine receptors on lymphocytes. Roszkowski, W., Plaut, M., Lichtenstein, L.M. Science (1977) [Pubmed]
  16. Inhibitory effects of heparin plus cortisone acetate on endothelial cell growth both in cultures and in tumor masses. Sakamoto, N., Tanaka, N.G., Tohgo, A., Osada, Y., Ogawa, H. J. Natl. Cancer Inst. (1987) [Pubmed]
  17. The effect of potassium loading on sodium excretion and plasma renin activity in Addisonian man. Miller, P.D., Waterhouse, C., Owens, R., Cohen, E. J. Clin. Invest. (1975) [Pubmed]
  18. Potentiation of hydrocortisone activity in skin by glycyrrhetinic acid. Teelucksingh, S., Mackie, A.D., Burt, D., McIntyre, M.A., Brett, L., Edwards, C.R. Lancet (1990) [Pubmed]
  19. Bacterial metabolism of corticoids with particular reference to the 21-dehydroxylation. Winter, J., Bokkenheuser, V.D., Ponticorvo, L. J. Biol. Chem. (1979) [Pubmed]
  20. Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn's disease. Neurath, M.F., Wanitschke, R., Peters, M., Krummenauer, F., Meyer zum Büschenfelde, K.H., Schlaak, J.F. Gut (1999) [Pubmed]
  21. A functionally compromised intermediate in extrathymic CD8+ T cell deletion. Dillon, S.R., MacKay, V.L., Fink, P.J. Immunity (1995) [Pubmed]
  22. T cell development. Precursors and inducer requirements of helper effector and feedback suppression inducer cell sets. Shen, F.W., McDougal, J.S., Bard, J., Cort, S.P. J. Exp. Med. (1981) [Pubmed]
  23. The in vitro effects of Bordetella pertussis lymphocytosis-promoting factor on murine lymphocytes. I. Proliferative response. Kong, A.S., Morse, S.I. J. Exp. Med. (1977) [Pubmed]
  24. Stages in development of mink cell focus-inducing (MCF) virus-accelerated leukemia in AKR mice. O'Donnell, P.V., Woller, R., Chu, A. J. Exp. Med. (1984) [Pubmed]
  25. Prevention of necrotizing enterocolitis in the rat with prenatal cortisone. Israel, E.J., Schiffrin, E.J., Carter, E.A., Freiberg, E., Walker, W.A. Gastroenterology (1990) [Pubmed]
  26. Concanavalin A potentiates syngeneic response in murine lymphocytes. Ozato, K., Ebert, J.D. J. Exp. Med. (1976) [Pubmed]
  27. Fc-receptors, Ia-antigens, and immunoglobulin on normal and activated mouse T lymphocytes. Krammer, P.H., Hudson, L., Sprent, J. J. Exp. Med. (1975) [Pubmed]
  28. A selective culture system for generating terminal deoxynucleotidyl transferase-positive (TdT+) lymphoid precursor cells in vitro. I. Description of the culture system. Hayashi, J., Medlock, E.S., Goldschneider, I. J. Exp. Med. (1984) [Pubmed]
  29. Generation of T-helper cells in vitro. I. Cellular and antigen requirements. McDougal, J.S., Gordon, D.S. J. Exp. Med. (1977) [Pubmed]
  30. Tumor necrosis factor alpha and interleukin 1beta enhance the cortisone/cortisol shuttle. Escher, G., Galli, I., Vishwanath, B.S., Frey, B.M., Frey, F.J. J. Exp. Med. (1997) [Pubmed]
  31. Differential response of early erythropoietic and granulopoietic progenitors to dexamethasone and cortisone. Zalman, F., Maloney, M.A., Patt, H.M. J. Exp. Med. (1979) [Pubmed]
  32. The arachidonic acid cascade is involved in the masculinizing action of testosterone on embryonic external genitalia in mice. Gupta, C., Goldman, A.S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  33. Efficacy of antitumor chemotherapy in C3H mice enhanced by the antiangiogenesis steroid, cortisone acetate. Lee, K., Erturk, E., Mayer, R., Cockett, A.T. Cancer Res. (1987) [Pubmed]
  34. Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation. Rabbitt, E.H., Ayuk, J., Boelaert, K., Sheppard, M.C., Hewison, M., Stewart, P.M., Gittoes, N.J. Oncogene (2003) [Pubmed]
  35. Genetic association of 11 beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) flanking microsatellites with essential hypertension in blacks. Watson, B., Bergman, S.M., Myracle, A., Callen, D.F., Acton, R.T., Warnock, D.G. Hypertension (1996) [Pubmed]
  36. Pyridostigmine blocks the inhibitory effect of glucocorticoids on growth hormone-releasing hormone stimulated growth hormone secretion in normal man. Giustina, A., Girelli, A., Doga, M., Bodini, C., Bossoni, S., Romanelli, G., Wehrenberg, W.B. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  37. Corticotropin releasing hormone (CRH) promoter polymorphisms in various ethnic groups of patients with rheumatoid arthritis. Baerwald, C.G., Mok, C.C., Tickly, M., Lau, C.S., Wordsworth, B.P., Ollier, B., Panayi, G.S., Lanchbury, J.S. Zeitschrift für Rheumatologie. (2000) [Pubmed]
  38. Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17. Gasser, D.L., Mele, L., Lees, D.D., Goldman, A.S. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  39. Treatment of lupus nephritis in adult (NZB + NZW)F1 mice by cortisone-facilitated tolerance to nucleic acid antigens. Borel, Y., Lewis, R.M., André-Schwartz, J., Stollar, B.D., Diener, E. J. Clin. Invest. (1978) [Pubmed]
  40. A novel mechanism of complement-independent clearance of red cells deficient in glycosyl phosphatidylinositol-linked proteins. Jasinski, M., Pantazopoulos, P., Rother, R.P., van Rooijen, N., Song, W.C., Molina, H., Bessler, M. Blood (2004) [Pubmed]
  41. Contrasting splenic mechanisms in the blood clearance of red blood cells and colloidal particles. Klausner, M.A., Hirsch, L.J., Leblond, P.F., Chamberlain, J.K., Klemperer, M.R., Segel, G.B. Blood (1975) [Pubmed]
  42. Pathogenesis of reactivated latent murine cytomegalovirus infection. Shanley, J.D., Jordan, M.C., Cook, M.L., Stevens, J.G. Am. J. Pathol. (1979) [Pubmed]
  43. Immunosuppressive effects of glucocorticosteroids: differential effects of acute vs chronic administration on cell-mediated immunity. Balow, J.E., Hurley, D.L., Fauci, A.S. J. Immunol. (1975) [Pubmed]
WikiGenes - Universities