Chemical Compound Review:
Hexarelin (2S)-6-amino-2-[[2-[[(2S)-2- [[(2S)-2...
Synonyms:
AC1NUYYT, SureCN3049733, LS-191993, AKOS015896043, I06-1821, ...
Arnaldi,
Mancini,
Kola,
Appolloni,
Freddi,
Concettoni,
Bearzi,
Masini,
Boscaro,
Mantero,
Korbonits,
Kaltsas,
Perry,
Putignano,
Grossman,
Besser,
Trainer,
Torsello,
Bresciani,
Rossoni,
Avallone,
Tulipano,
Cocchi,
Bulgarelli,
Deghenghi,
Berti,
Locatelli,
Baratta,
Saleri,
Mainardi,
Valle,
Giustina,
Tamanini,
Gasperi,
Aimaretti,
Scarcello,
Corneli,
Cosci,
Arvat,
Martino,
Ghigo,
Korbonits,
Kaltsas,
Perry,
Grossman,
Monson,
Besser,
Trainer,
Brywe,
Leverin,
Gustavsson,
Mallard,
Granata,
Destefanis,
Volante,
Hagberg,
Ghigo,
Isgaard,
Cassoni,
Papotti,
Ghè,
Catapano,
Sapino,
Graziani,
Deghenghi,
Reissmann,
Ghigo,
Muccioli,
Deghenghi,
Papotti,
Ghigo,
Muccioli,
- Low dose hexarelin and growth hormone (GH)-releasing hormone as a diagnostic tool for the diagnosis of GH deficiency in adults: comparison with insulin-induced hypoglycemia test. Gasperi, M., Aimaretti, G., Scarcello, G., Corneli, G., Cosci, C., Arvat, E., Martino, E., Ghigo, E. J. Clin. Endocrinol. Metab. (1999)
- Ghrelin plays a minor role in the physiological control of cardiac function in the rat. Torsello, A., Bresciani, E., Rossoni, G., Avallone, R., Tulipano, G., Cocchi, D., Bulgarelli, I., Deghenghi, R., Berti, F., Locatelli, V. Endocrinology (2003)
- The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction. Tivesten, A., Bollano, E., Caidahl, K., Kujacic, V., Sun, X.Y., Hedner, T., Hjalmarson, A., Bengtsson, B.A., Isgaard, J. Endocrinology (2000)
- Growth hormone-releasing peptide hexarelin reduces neonatal brain injury and alters Akt/glycogen synthase kinase-3beta phosphorylation. Brywe, K.G., Leverin, A.L., Gustavsson, M., Mallard, C., Granata, R., Destefanis, S., Volante, M., Hagberg, H., Ghigo, E., Isgaard, J. Endocrinology (2005)
- Endocrine, metabolic and cardioprotective effects of hexarelin in obese Zucker rats. De Gennaro-Colonna, V., Rossoni, G., Cocchi, D., Rigamonti, A.E., Berti, F., Muller, E.E. J. Endocrinol. (2000)
- Absence of desensitization by hexarelin to subsequent GH releasing hormone-mediated GH secretion in patients with anorexia nervosa. Popovic, V., Micic, D., Djurovic, M., Obradovic, S., Casanueva, F.F., Dieguez, C. Clin. Endocrinol. (Oxf) (1997)
- Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release. Torsello, A., Luoni, M., Schweiger, F., Grilli, R., Guidi, M., Bresciani, E., Deghenghi, R., Müller, E.E., Locatelli, V. Eur. J. Pharmacol. (1998)
- Acute administration of hexarelin stimulates GH secretion during day and night in normal men. Loche, S., Colao, A., Cappa, M., Ferone, D., Merola, B., Faedda, A., Imbimbo, B.P., Deghenghi, R., Lombardi, G. Clin. Endocrinol. (Oxf) (1997)
- Growth hormone-releasing peptides and their analogs. Camanni, F., Ghigo, E., Arvat, E. Frontiers in neuroendocrinology. (1998)
- Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. Arnaldi, G., Mancini, T., Kola, B., Appolloni, G., Freddi, S., Concettoni, C., Bearzi, I., Masini, A., Boscaro, M., Mantero, F. J. Clin. Endocrinol. Metab. (2003)
- Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines. Cassoni, P., Papotti, M., Ghè, C., Catapano, F., Sapino, A., Graziani, A., Deghenghi, R., Reissmann, T., Ghigo, E., Muccioli, G. J. Clin. Endocrinol. Metab. (2001)
- Hexarelin as a test of pituitary reserve in patients with pituitary disease. Korbonits, M., Kaltsas, G., Perry, L.A., Grossman, A.B., Monson, J.P., Besser, G.M., Trainer, P.J. Clin. Endocrinol. (Oxf) (1999)
- Somatotrope responsiveness to Hexarelin, a synthetic hexapeptide, is refractory to the inhibitory effect of glucose in obesity. Grottoli, S., Maccario, M., Procopio, M., Oleandri, S.E., Arvat, E., Gianotti, L., Deghenghi, R., Camanni, F., Ghigo, E. Eur. J. Endocrinol. (1996)
- Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Frascarelli, S., Ghelardoni, S., Ronca-Testoni, S., Zucchi, R. Basic Res. Cardiol. (2003)
- Effects of alprazolam, a benzodiazepine, on the ACTH-, GH- and PRL-releasing activity of hexarelin, a synthetic peptidyl GH secretagogue (GHS), in patients with simple obesity and in patients with Cushing's disease. Grottoli, S., Arvat, E., Gauna, C., Maccagno, B., Ramunni, J., Giordano, R., Maccario, M., Deghenghi, R., Ghigo, E. Pituitary (1999)
- Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man. Ghigo, E., Arvat, E., Gianotti, L., Imbimbo, B.P., Lenaerts, V., Deghenghi, R., Camanni, F. J. Clin. Endocrinol. Metab. (1994)
- Growth hormone secretagogue binding sites in peripheral human tissues. Papotti, M., Ghè, C., Cassoni, P., Catapano, F., Deghenghi, R., Ghigo, E., Muccioli, G. J. Clin. Endocrinol. Metab. (2000)
- Leptin regulates GH gene expression and secretion and nitric oxide production in pig pituitary cells. Baratta, M., Saleri, R., Mainardi, G.L., Valle, D., Giustina, A., Tamanini, C. Endocrinology (2002)
- Pro-VGF-derived peptides induce penile erection in male rats: Involvement of paraventricular nitric oxide. Succu, S., Mascia, M.S., Melis, T., Sanna, F., Melis, M.R., Possenti, R., Argiolas, A. Neuropharmacology (2005)
- Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro. Pang, J.J., Xu, R.K., Xu, X.B., Cao, J.M., Ni, C., Zhu, W.L., Asotra, K., Chen, M.C., Chen, C. Am. J. Physiol. Heart Circ. Physiol. (2004)
- Hexarelin decreases slow-wave sleep and stimulates the secretion of GH, ACTH, cortisol and prolactin during sleep in healthy volunteers. Frieboes, R.M., Antonijevic, I.A., Held, K., Murck, H., Pollmächer, T., Uhr, M., Steiger, A. Psychoneuroendocrinology (2004)
- Partial recovery of skeletal muscle sodium channel properties in aged rats chronically treated with growth hormone or the GH-secretagogue hexarelin. Desaphy, J.F., De Luca, A., Pierno, S., Imbrici, P., Camerino, D.C. J. Pharmacol. Exp. Ther. (1998)
- Hexarelin-induced growth hormone, cortisol, and prolactin release: a dose-response study. Massoud, A.F., Hindmarsh, P.C., Brook, C.G. J. Clin. Endocrinol. Metab. (1996)
- Growth hormone status during long-term hexarelin therapy. Rahim, A., O'Neill, P.A., Shalet, S.M. J. Clin. Endocrinol. Metab. (1998)
- Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects. Arvat, E., Gianotti, L., Grottoli, S., Imbimbo, B.P., Lenaerts, V., Deghenghi, R., Camanni, F., Ghigo, E. J. Clin. Endocrinol. Metab. (1994)
- The growth hormone secretagogue hexarelin stimulates the hypothalamo-pituitary-adrenal axis via arginine vasopressin. Korbonits, M., Kaltsas, G., Perry, L.A., Putignano, P., Grossman, A.B., Besser, G.M., Trainer, P.J. J. Clin. Endocrinol. Metab. (1999)
- Interaction of the growth hormone releasing peptide hexarelin with somatostatin. Massoud, A.F., Hindmarsh, P.C., Brook, C.G. Clin. Endocrinol. (Oxf) (1997)
- Hexarelin, a synthetic growth-hormone releasing peptide, shows no interaction with corticotropin-releasing hormone and vasopressin on adrenocorticotropin and cortisol secretion in humans. Arvat, E., Maccagno, B., Ramunni, J., Di Vito, L., Broglio, F., Deghenghi, R., Camanni, F., Ghigo, E. Neuroendocrinology (1997)
- The effect of growth hormone secretagogues and neuropeptide Y on hypothalamic hormone release from acute rat hypothalamic explants. Korbonits, M., Little, J.A., Forsling, M.L., Tringali, G., Costa, A., Navarra, P., Trainer, P.J., Grossman, A.B. J. Neuroendocrinol. (1999)
- Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland. Deghenghi, R., Papotti, M., Ghigo, E., Muccioli, G. J. Endocrinol. Invest. (2001)
- The effects of dose, nutrition, and age on hexarelin-induced anterior pituitary hormone secretion in adult patients on maintenance hemodialysis. Jenkins, R.C., El Nahas, A.M., Wilkie, M.E., Brown, C.B., Jones, J., Ghigo, E., Ross, R.J. J. Clin. Endocrinol. Metab. (1999)