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Chemical Compound Review

Sporanox     2-butan-2-yl-4-[4-[4-[4- [[(2S,4S)-2-(2,4...

Synonyms: Canadiol, Hyphanox, Itrizole, Sporanos, Sporonox, ...
 
 
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Disease relevance of R 51211

 

Psychiatry related information on R 51211

  • The scores on the Brief Psychiatric Rating Scale decreased significantly but only by 6% after itraconazole treatment (P < .05); however, the scores on the Udvalg for Kliniske Undersøgelser Side Effect Rating Scale were not changed [4].
  • Barnes Akathisia Rating Scale (BARS) of subjects with CYP2D6*10/*10 in the presence of itraconazole pretreatment was significantly higher than that of subjects with CYP2D6*1/*1 genotype in the period of placebo pretreatment [5].
  • Demonstrating that ketoconazole and itraconazole are reaching the systemic circulation by obtaining serum concentrations may be clinically useful due to the large variability in their absorption and issues of patient compliance which may be seen with these agents [6].
  • Hallucinations associated with itraconazole therapy [7].
  • Consequently, we have used a previously published decision-making algorithm to determine whether clinical pharmacokinetic monitoring of itraconazole is warranted [8].
 

High impact information on R 51211

 

Chemical compound and disease context of R 51211

 

Biological context of R 51211

 

Anatomical context of R 51211

 

Associations of R 51211 with other chemical compounds

 

Gene context of R 51211

 

Analytical, diagnostic and therapeutic context of R 51211

References

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  4. Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients. Jung, S.M., Kim, K.A., Cho, H.K., Jung, I.G., Park, P.W., Byun, W.T., Park, J.Y. Clin. Pharmacol. Ther. (2005) [Pubmed]
  5. Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjects. Park, J.Y., Shon, J.H., Kim, K.A., Jung, H.J., Shim, J.C., Yoon, Y.R., Cha, I.J., Shin, J.G. Journal of clinical psychopharmacology. (2006) [Pubmed]
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  9. Rhabdomyolysis from the coadministration of lovastatin and the antifungal agent itraconazole. Lees, R.S., Lees, A.M. N. Engl. J. Med. (1995) [Pubmed]
  10. Use of terfenadine and contraindicated drugs. Thompson, D., Oster, G. JAMA (1996) [Pubmed]
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  13. Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate as empirical antifungal therapy for persistent fever in neutropenic patients with cancer who are receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. Boogaerts, M., Winston, D.J., Bow, E.J., Garber, G., Reboli, A.C., Schwarer, A.P., Novitzky, N., Boehme, A., Chwetzoff, E., De Beule, K. Ann. Intern. Med. (2001) [Pubmed]
  14. Itraconazole compared with amphotericin B plus flucytosine in AIDS patients with cryptococcal meningitis. de Gans, J., Portegies, P., Tiessens, G., Eeftinck Schattenkerk, J.K., van Boxtel, C.J., van Ketel, R.J., Stam, J. AIDS (1992) [Pubmed]
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  17. Congestive heart failure associated with itraconazole. Ahmad, S.R., Singer, S.J., Leissa, B.G. Lancet (2001) [Pubmed]
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  19. Pharmacokinetics of lower doses of saquinavir soft-gel caps (800 and 1200 mg twice daily) boosted with itraconazole in HIV-1-positive patients. Cardiello, P.G., Samor, T., Burger, D., Hoetelmans, R., Mahanontharit, A., Ruxrungtham, K., Lange, J.M., Cooper, D.A., Phanuphak, P. Antivir. Ther. (Lond.) (2003) [Pubmed]
  20. Elimination of Aspergillus infection in allogeneic stem cell transplant recipients with long-term itraconazole prophylaxis: prevention is better than treatment. Winston, D.J., Emmanouilides, C., Bartoni, K., Schiller, G.J., Paquette, R., Territo, M.C. Blood (2004) [Pubmed]
  21. Analysis of compassionate use itraconazole therapy for invasive aspergillosis by the NIAID Mycoses Study Group criteria. Stevens, D.A., Lee, J.Y. Arch. Intern. Med. (1997) [Pubmed]
  22. Itraconazole therapy for cryptococcal meningitis and cryptococcosis. Denning, D.W., Tucker, R.M., Hanson, L.H., Hamilton, J.R., Stevens, D.A. Arch. Intern. Med. (1989) [Pubmed]
  23. The KEX2 gene of Candida glabrata is required for cell surface integrity. Bader, O., Schaller, M., Klein, S., Kukula, J., Haack, K., Mühlschlegel, F., Korting, H.C., Schäfer, W., Hube, B. Mol. Microbiol. (2001) [Pubmed]
  24. Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial. Wark, P.A., Hensley, M.J., Saltos, N., Boyle, M.J., Toneguzzi, R.C., Epid, G.D., Simpson, J.L., McElduff, P., Gibson, P.G. J. Allergy Clin. Immunol. (2003) [Pubmed]
  25. Airborne outbreak of nosocomial Scedosporium prolificans infection. Guerrero, A., Torres, P., Duran, M.T., Ruiz-Díez, B., Rosales, M., Rodriguez-Tudela, J.L. Lancet (2001) [Pubmed]
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  27. A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Gachotte, D., Pierson, C.A., Lees, N.D., Barbuch, R., Koegel, C., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  28. Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide. Niemi, M., Backman, J.T., Neuvonen, M., Neuvonen, P.J. Diabetologia (2003) [Pubmed]
  29. Invasive aspergillosis. Disease spectrum, treatment practices, and outcomes. I3 Aspergillus Study Group. Patterson, T.F., Kirkpatrick, W.R., White, M., Hiemenz, J.W., Wingard, J.R., Dupont, B., Rinaldi, M.G., Stevens, D.A., Graybill, J.R. Medicine (Baltimore) (2000) [Pubmed]
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  32. Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide. Niemi, M., Backman, J.T., Juntti-Patinen, L., Neuvonen, M., Neuvonen, P.J. British journal of clinical pharmacology. (2005) [Pubmed]
  33. Isolation, characterization, and regulation of the Candida albicans ERG27 gene encoding the sterol 3-keto reductase. Pierson, C.A., Jia, N., Mo, C., Lees, N.D., Sturm, A.M., Eckstein, J., Barbuct, R., Bard, M. Med. Mycol. (2004) [Pubmed]
  34. Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. Suh, J.W., Koo, B.K., Zhang, S.Y., Park, K.W., Cho, J.Y., Jang, I.J., Lee, D.S., Sohn, D.W., Lee, M.M., Kim, H.S. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. (2006) [Pubmed]
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  37. Itraconazole increases but grapefruit juice greatly decreases plasma concentrations of celiprolol. Lilja, J.J., Backman, J.T., Laitila, J., Luurila, H., Neuvonen, P.J. Clin. Pharmacol. Ther. (2003) [Pubmed]
  38. The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect. Varis, T., Kivistö, K.T., Backman, J.T., Neuvonen, P.J. Clin. Pharmacol. Ther. (2000) [Pubmed]
 
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