Chemical Compound Review:
AG-K-04502 5-methyl-6-[[(3,4,5- trimethoxyphenyl)amino...
Synonyms:
CTK6J8809, ZINC00598852, AC1L1KO2
This record was replaced with 5583.
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- Pharmacology and toxicity of a potent "nonclassical" 2,4-diamino quinazoline folate antagonist, trimetrexate, in normal dogs. Weir, E.C., Cashmore, A.R., Dreyer, R.N., Graham, M.L., Hsiao, N., Moroson, B.A., Sawicki, W.L., Bertino, J.R. Cancer Res. (1982)
- Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells. Rhee, M.S., Balinska, M., Bunni, M., Priest, D.G., Maley, G.F., Maley, F., Galivan, J. Cancer Res. (1990)
- Quantitation of folic acid enhancement of antifolate synergism. Gaumont, Y., Kisliuk, R.L., Parsons, J.C., Greco, W.R. Cancer Res. (1992)
- Trimetrexate: predictors of severe or life-threatening toxic effects. Eisenhauer, E.A., Zee, B.C., Pater, J.L., Walsh, W.R. J. Natl. Cancer Inst. (1988)
- Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Yin, D.X., Schimke, R.T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Pediatric phase I trial and pharmacokinetic study of trimetrexate. Balis, F.M., Patel, R., Luks, E., Doherty, K.M., Holcenberg, J.S., Tan, C., Reaman, G.H., Belasco, J., Ettinger, L.J., Zimm, S. Cancer Res. (1987)
- Potent in vitro and in vivo antitoxoplasma activity of the lipid-soluble antifolate trimetrexate. Allegra, C.J., Kovacs, J.A., Drake, J.C., Swan, J.C., Chabner, B.A., Masur, H. J. Clin. Invest. (1987)
- A gene transfer strategy for making bone marrow cells resistant to trimetrexate. Spencer, H.T., Sleep, S.E., Rehg, J.E., Blakley, R.L., Sorrentino, B.P. Blood (1996)
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- Trimetrexate in relapsed T-cell lymphoma with skin involvement. Sarris, A.H., Phan, A., Duvic, M., Romaguera, J., McLaughlin, P., Mesina, O., King, K., Medeiros, L.J., Rassidakis, G.Z., Samuels, B., Cabanillas, F. J. Clin. Oncol. (2002)
- Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent. Allegra, C.J., Kovacs, J.A., Drake, J.C., Swan, J.C., Chabner, B.A., Masur, H. J. Exp. Med. (1987)
- Cells exposed to antifolates show increased cellular levels of proteins fused to dihydrofolate reductase: a method to modulate gene expression. Mayer-Kuckuk, P., Banerjee, D., Malhotra, S., Doubrovin, M., Iwamoto, M., Akhurst, T., Balatoni, J., Bornmann, W., Finn, R., Larson, S., Fong, Y., Gelovani Tjuvajev, J., Blasberg, R., Bertino, J.R. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate. Galivan, J., Nimec, Z., Rhee, M., Boschelli, D., Oronsky, A.L., Kerwar, S.S. Cancer Res. (1988)
- Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. Diddens, H., Niethammer, D., Jackson, R.C. Cancer Res. (1983)
- Drug resistance results in alterations in expression of immune recognition molecules and failure to express Fas (CD95). Bhushan, A., Kupperman, J.L., Stone, J.E., Kimberly, P.J., Calman, N.S., Hacker, M.P., Birge, R.B., Tritton, T.R., Newell, M.K. Immunol. Cell Biol. (1998)
- Cytotoxic effects of folate antagonists against methotrexate-resistant human leukemic lymphoblast CCRF-CEM cell lines. Mini, E., Moroson, B.A., Franco, C.T., Bertino, J.R. Cancer Res. (1985)
- The toxicity of antifolates in Babesia bovis. Nott, S.E., Bagnara, A.S. Int. J. Parasitol. (1993)
- Enzyme studies of methotrexate-resistant human leukemic cell (K562) subclones. Koizumi, S., Allegra, C.J. Leuk. Res. (1992)
- Trimetrexate: a second generation folate antagonist in clinical trial. Lin, J.T., Bertino, J.R. J. Clin. Oncol. (1987)
- Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy. McMillin, D.W., Hewes, B., Gangadharan, B., Archer, D.R., Mittler, R.S., Spencer, H.T. Hum. Gene Ther. (2006)