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Chemical Compound Review

D-Lysine     (2R)-2,6-diaminohexanoic acid

Synonyms: D-Lysin, Poly-D-lysine, PubChem6286, PubChem12448, L-Lysine (9CI), ...
 
 
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Disease relevance of lysine

 

High impact information on lysine

  • When explants or reaggregates of small neurons from early postnatal mouse cerebella are plated on a mixture of laminin and poly-D-lysine, one observes small cells with an orientation of processes largely perpendicular to the direction of granule cell neurites after several days [6].
  • Transient increases in cytosolic free calcium concentration, [Ca2+]i, appear to be required for the migration of human neutrophils on poly-D-lysine-coated glass in the presence of dilute serum (Marks, P. W., and F. R. Maxfield. 1990. J. Cell Biol. 110:43-52) [7].
  • C6 cell spreading on inhibitor-free substrates such as CNS gray matter, peripheral nervous system myelin, glass, or poly-D-lysine was not sensitive to 1,10-phenanthroline [8].
  • Although the current density remained unchanged in neurons on astrocytes, that in neurons on PDL decreased and became statistically lower beginning after 2 HIC [9].
  • At 16 hr after plating on a substrate of poly-D-lysine, in a serum-free or serum-supplemented growth medium, using a microisland culturing method, 95% of the cells stained positive for neuron-specific enolase, 20% for tyrosine hydroxylase, and < 5% for vimentin [10].
 

Chemical compound and disease context of lysine

 

Biological context of lysine

  • Furthermore, inhibitors of TRAIL, including recombinant soluble TRAIL receptors and a neutralizing antibody against TRAIL, blocked apoptosis of serum-starved HMECs plated on the nonintegrin attachment factor poly-d-lysine [14].
  • Cell survival was enhanced under optimal conditions of cell attachment and cell-to-cell contact as provided by extracellular matrix components or poly-D-lysine [15].
  • Cultured CHO cells were treated with the radiomimetic antitumor agent bleomycin (BLM) and post-treated with the polycationic compound poly-D-lysine (PDL), recently reported by us as able to potentiate chromosome damage induced by X-rays and chemical mutagens in both plant and mammalian cells [16].
  • Such a phenomenon could explain why injected plasmid DNA is more stable in vivo when it is associated with poly-D-lysine [17].
  • When U-251 cells were plated in G2 medium on poly-D-lysine precoated dishes, their growth rate was 77% and final cell density was 82% of serum-grown counterparts [18].
 

Anatomical context of lysine

 

Associations of lysine with other chemical compounds

 

Gene context of lysine

 

Analytical, diagnostic and therapeutic context of lysine

References

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