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Chemical Compound Review

Aerodiol     (8S,9S,13S,14S,17S)-13- methyl-6,7,8,9,11...

Synonyms: Estrace, Ovocyclin, Vivelle, estradiol, Oestradiol, ...
 
 
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Disease relevance of Ovocyclin

  • Estrogen replacement therapy in patients with endometrial cancer: a survey of prescription intention of Belgian gynecologists [1].
  • Estrogen receptors, breast cancer, and smoking [2].
  • Bile cholesterol saturation correlated with obesity (r = 0.41; P less than 0.001) and urinary estrogen excretion (r = 0.44; P less than 0.001) [3].
  • BACKGROUND: Estrogen-replacement therapy prevents osteoporosis in postmenopausal women by inhibiting bone resorption, but the balance between its long-term risks and benefits remains unclear [4].
  • Finally, this investigation contradicts the speculation that the association between this cancer and estrogen use can be explained by swifter diagnosis for estrogen users, misclassification of estrogen-related hyperplasia or treatment of early symptoms of the tumor with estrogen [5].
  • Estradiol treatment reduced weight gain and increased atrial ANP synthesis as well as decreased ANP clearance NPR-C receptors, resulting in elevation of circulating ANP level [6].
 

Psychiatry related information on Ovocyclin

 

High impact information on Ovocyclin

 

Chemical compound and disease context of Ovocyclin

 

Biological context of Ovocyclin

 

Anatomical context of Ovocyclin

  • The induction of the 46K secreted protein(s) makes these cell lines excellent in vitro systems for studying the mechanism of estrogen and anti-estrogen action [25].
  • We conclude that many estrogen preparations subject the endometrium to a potent stimulus [26].
  • Growth and function of primary cultures of granulosa cells obtained from immature, hypophysectomized, estrogen-treated rats were compared in serum-containing and serum-free media [27].
  • Quantitation of elongating form A and B RNA polymerases in chick oviduct nuclei and effects of estradiol [28].
  • Furthermore, neither normal human nor CF fibroblasts could be demonstrated to contain detectable receptor activity for 3H-17 beta-estradiol [29].
 

Associations of Ovocyclin with other chemical compounds

 

Gene context of Ovocyclin

  • We show here a novel role for cyclin D1 in growth regulation of estrogen-responsive tissues by potentiating transcription of estrogen receptor-regulated genes [24].
  • Here we report that estradiol (E2) triggers a robust increase in the number of excitatory inputs to POMC neurons in the arcuate nucleus of wild-type rats and mice [36].
  • However, estrogen-induced decrease in body weight was dependent on Stat3 activation in the brain [36].
  • These results raise the possibility that wild-type BRCA1 suppresses estrogen-dependent transcriptional pathways related to mammary epithelial cell proliferation and that loss of this ability contributes to tumorigenesis [37].
  • AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription [38].
  • These large-scale studies of elderly men and women indicate that the ERalpha cofactor RIZ gene has a prominent effect on BMD, and the P704 genotype modulates the impact of estradiol on BMD [39].
  • Experiments with bone marrow cells from ER-deficient mice and the ER antagonist ICI182,780 showed that estradiol acted primarily via ERalpha to regulate DC differentiation [40].
  • In men, significant associations were detected between CYP19A1 polymorphisms and estradiol and testosterone levels, and the estradiol to testosterone ratio (P ranges 0.0005-0.01) [41].
 

Analytical, diagnostic and therapeutic context of Ovocyclin

  • We compared 14 women who had undergone oophorectomy during young adulthood, 14 normal perimenopausal women, and 14 normal postmenopausal women (mean ages, 54, 52, and 73 years, respectively; mean duration of estrogen deficiency, 22, 0.3, and 22 years, respectively) [42].
  • Radioimmunoassay confirmed a lower mean estradiol concentration (amenorrheic group, 38.58 pg per milliliter; eumenorrheic group, 106.99 pg per milliliter) and progesterone peak (amenorrheic group, 1.25 ng per milliliter; eumenorrheic group, 12.75 ng per milliliter) in the amenorrheic women, in four venous samples drawn at seven-day intervals [43].
  • Vitellogenin gene expression in male Xenopus hepatocytes during primary and secondary stimulation with estrogen in cell cultures [44].
  • In the receptor-rich group, the survival of the 21 patients receiving combined therapy was significantly longer than that of 19 patients receiving estrogen as initial therapy (followed by chemotherapy after failure or relapse) [45].
  • METHODS: We compared the sensitivity and specificity of transvaginal ultrasonography and endometrial biopsy for the detection of endometrial disease in 448 postmenopausal women who received estrogen alone, cyclic or continuous estrogen-progesterone, or placebo for three years [46].

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  20. Opposing effects of runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness. Chimge, N.O., Baniwal, S.K., Luo, J., Coetzee, S., Khalid, O., Berman, B.P., Tripathy, D., Ellis, M.J., Frenkel, B. Clin. Cancer Res. (2012) [Pubmed]
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