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Chemical Compound Review:

Desoxyn (2S)-1-phenylpropan-2-amine

Synonyms: Dexedrine, Phenamine, Thyramine, Amfetamine, Dexamfetamine, ...

Shi, W.X. et al., King, S. et al., Cenajek, D. et al., Harris, D.S. et al.

Wei-Xing Shi, Xiang-Yang Zhang, Chen-Lun Pun, Benjamin S. Bunney,

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High impact information on Dexedrine

Dextroamphetamine (INN, dexamfetamine) half-life (all routes) was 16.2 hours [1].
A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents [2].
The effect of cyproheptadine (CPH) given in doses of 1.25 and 5 mg/kg intraperitoneally one hour before administration of D-(+)-amphetamine (AMPH) 5 mg/kg subcutaneously was studied [3].

Associations of Dexedrine with other chemical compounds

The suggestion that clozapine inhibits the excitatory effect of D-amphetamine is further supported by the finding that clozapine, given after D-amphetamine, reliably reversed D-amphetamine-induced excitation in raclopride-treated rats [4].

References

The bioavailability of intranasal and smoked methamphetamine. Harris, D.S., Boxenbaum, H., Everhart, E.T., Sequeira, G., Mendelson, J.E., Jones, R.T. Clin. Pharmacol. Ther. (2003) [Pubmed]
A systematic review and economic model of the effectiveness and cost-effectiveness of methylphenidate, dexamfetamine and atomoxetine for the treatment of attention deficit hyperactivity disorder in children and adolescents. King, S., Griffin, S., Hodges, Z., Weatherly, H., Asseburg, C., Richardson, G., Golder, S., Taylor, E., Drummond, M., Riemsma, R. Health technology assessment (Winchester, England) (2006) [Pubmed]
Investigations on the interaction between cyproheptadine and amphetamine. Cenajek, D., Chodera, A., Godlewski, J., Wójciak, Z. Acta physiologica Polonica. (1980) [Pubmed]
Clozapine blocks D-amphetamine-induced excitation of dopamine neurons in the ventral tegmental area. Shi, W.X., Zhang, X.Y., Pun, C.L., Bunney, B.S. Neuropsychopharmacology (2007) [Pubmed]

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