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Chemical Compound Review

BRADYKININ     2-[[2-[[1-[2-[[2-[2-[[1-[1- [2-amino-5...

Synonyms: kinin 9, CHEMBL262419, BRS 640, PRS 640, LS-45210, ...
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Disease relevance of BRADYKININ


Psychiatry related information on BRADYKININ


High impact information on BRADYKININ

  • CONCLUSIONS: These data confirm that bradykinin contributes to the short-term effects of ACE inhibition on blood pressure in normotensive and hypertensive persons and suggest that bradykinin also contributes to the short-term effects of ACE inhibition on the renin-angiotensin system [11].
  • In this study, a specific bradykinin-receptor antagonist, icatibant acetate (HOE 140), was used to determine the contribution of bradykinin to the short-term effects of ACE inhibition on blood pressure and plasma renin activity in both normotensive and hypertensive subjects [11].
  • Desensitization of the kinase C pathway by prolonged exposure to phorbol abolished the induction of c-myc by subsequent phorbol challenge and attenuated c-myc induction by PDGF and bradykinin, but did not affect PDGF-stimulated mitogenesis [12].
  • HSDM1C1 cells possess a B2 bradykinin receptor, a type more sensitive to native bradykinin than to related peptides, including Met-Lys- and desArg9-bradykinin [2].
  • These data suggest that Hageman-factor fragments are potent hypotensive agents, presumably because they trigger the generation of bradykinin in recipients [13].

Chemical compound and disease context of BRADYKININ


Biological context of BRADYKININ


Anatomical context of BRADYKININ

  • In the vascular system, endothelium-derived relaxing factor (EDRF) is the name of the local hormone released from endothelial cells in response to vasodilators such as acetylcholine, bradykinin and histamine [23].
  • This enzyme plays a key role in the production of angiotensin II and in the catabolism of bradykinin, two peptides involved in the modulation of vascular tone and in the proliferation of smooth muscle cells [24].
  • In these cells bradykinin rapidly hydrolyses PtdIns(4,5)P2 to InsP3 and DG, raises intracellular Ca2+ and hyperpolarizes then depolarizes the cell membrane [25].
  • Here, we show that bradykinin- or NGF-mediated potentiation of thermal sensitivity in vivo requires expression of VR1, a heat-activated ion channel on sensory neurons [26].
  • Bradykinin significantly increased calcium levels in neurons co-cultured with astrocytes, but not in solitary neurons [27].

Associations of BRADYKININ with other chemical compounds


Gene context of BRADYKININ


Analytical, diagnostic and therapeutic context of BRADYKININ


  1. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Bautista, D.M., Jordt, S.E., Nikai, T., Tsuruda, P.R., Read, A.J., Poblete, J., Yamoah, E.N., Basbaum, A.I., Julius, D. Cell (2006) [Pubmed]
  2. Regulation of prostaglandin synthesis mediated by thrombin and B2 bradykinin receptors in a fibrosarcoma cell line. Becherer, P.R., Mertz, L.F., Baenziger, N.L. Cell (1982) [Pubmed]
  3. Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases. Herwald, H., Mörgelin, M., Olsén, A., Rhen, M., Dahlbäck, B., Müller-Esterl, W., Björck, L. Nat. Med. (1998) [Pubmed]
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  5. Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: role in lung vascular diseases. Chand, N., Altura, B.M. Science (1981) [Pubmed]
  6. An internally controlled peripheral biomarker for Alzheimer's disease: Erk1 and Erk2 responses to the inflammatory signal bradykinin. Khan, T.K., Alkon, D.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. Do nociceptive signals from the pancreas travel in the dorsal column? Houghton, A.K., Wang, C.C., Westlund, K.N. Pain (2001) [Pubmed]
  8. A novel sequence polymorphism in the promoter region of the human B2-bradykinin receptor gene. Braun, A., Maier, E., Kammerer, S., Müller, B., Roscher, A.A. Hum. Genet. (1996) [Pubmed]
  9. Distribution of bradykinin B2 receptors in sheep brain and spinal cord visualized by in vitro autoradiography. Murone, C., Paxinos, G., McKinley, M.J., Oldfield, B.J., Muller-Esterl, W., Mendelsohn, F.A., Chai, S.Y. J. Comp. Neurol. (1997) [Pubmed]
  10. Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a multi-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group. Marmarou, A., Nichols, J., Burgess, J., Newell, D., Troha, J., Burnham, D., Pitts, L. J. Neurotrauma (1999) [Pubmed]
  11. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. Gainer, J.V., Morrow, J.D., Loveland, A., King, D.J., Brown, N.J. N. Engl. J. Med. (1998) [Pubmed]
  12. c-myc gene expression is stimulated by agents that activate protein kinase C and does not account for the mitogenic effect of PDGF. Coughlin, S.R., Lee, W.M., Williams, P.W., Giels, G.M., Williams, L.T. Cell (1985) [Pubmed]
  13. Hypotension associated with prekallikrein activator (Hageman-factor fragments) in plasma protein fraction. Alving, B.M., Hojima, Y., Pisano, J.J., Mason, B.L., Buckingham, R.E., Mozen, M.M., Finlayson, J.S. N. Engl. J. Med. (1978) [Pubmed]
  14. The control of microvascular permeability and blood pressure by neutral endopeptidase. Lu, B., Figini, M., Emanueli, C., Geppetti, P., Grady, E.F., Gerard, N.P., Ansell, J., Payan, D.G., Gerard, C., Bunnett, N. Nat. Med. (1997) [Pubmed]
  15. NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. Zhang, X., Huang, J., McNaughton, P.A. EMBO J. (2005) [Pubmed]
  16. Ischemic preconditioning: from adenosine receptor to KATP channel. Cohen, M.V., Baines, C.P., Downey, J.M. Annu. Rev. Physiol. (2000) [Pubmed]
  17. Mechanism and modification of bradykinin-induced coronary vasodilation. Needleman, P., Key, S.L., Denny, S.E., Isakson, P.C., Marshall GROUSI, Missouri 63110, n.u.l.l. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  18. Role of endogenous bradykinin in human coronary vasomotor control. Groves, P., Kurz, S., Just, H., Drexler, H. Circulation (1995) [Pubmed]
  19. Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Kondoh, G., Tojo, H., Nakatani, Y., Komazawa, N., Murata, C., Yamagata, K., Maeda, Y., Kinoshita, T., Okabe, M., Taguchi, R., Takeda, J. Nat. Med. (2005) [Pubmed]
  20. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. Tsutsumi, Y., Matsubara, H., Masaki, H., Kurihara, H., Murasawa, S., Takai, S., Miyazaki, M., Nozawa, Y., Ozono, R., Nakagawa, K., Miwa, T., Kawada, N., Mori, Y., Shibasaki, Y., Tanaka, Y., Fujiyama, S., Koyama, Y., Fujiyama, A., Takahashi, H., Iwasaka, T. J. Clin. Invest. (1999) [Pubmed]
  21. Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells. Portilla, D., Morrissey, J., Morrison, A.R. J. Clin. Invest. (1988) [Pubmed]
  22. Perception of bronchial obstruction in asthmatic patients. Relationship with bronchial eosinophilic inflammation and epithelial damage and effect of corticosteroid treatment. Roisman, G.L., Peiffer, C., Lacronique, J.G., Le Cae, A., Dusser, D.J. J. Clin. Invest. (1995) [Pubmed]
  23. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Garthwaite, J., Charles, S.L., Chess-Williams, R. Nature (1988) [Pubmed]
  24. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J.P., Arveiler, D., Luc, G., Bard, J.M., Bara, L., Ricard, S. Nature (1992) [Pubmed]
  25. Two polyphosphatidylinositide metabolites control two K+ currents in a neuronal cell. Higashida, H., Brown, D.A. Nature (1986) [Pubmed]
  26. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Chuang , H.H., Prescott, E.D., Kong, H., Shields, S., Jordt, S.E., Basbaum, A.I., Chao, M.V., Julius, D. Nature (2001) [Pubmed]
  27. Glutamate-mediated astrocyte-neuron signalling. Parpura, V., Basarsky, T.A., Liu, F., Jeftinija, K., Jeftinija, S., Haydon, P.G. Nature (1994) [Pubmed]
  28. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Gryglewski, R.J., Palmer, R.M., Moncada, S. Nature (1986) [Pubmed]
  29. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S.A., Schlessinger, J. Nature (1996) [Pubmed]
  30. Induction of vanilloid receptor channel activity by protein kinase C. Premkumar, L.S., Ahern, G.P. Nature (2000) [Pubmed]
  31. Effect of phospholipase C-gamma overexpression on PDGF-induced second messengers and mitogenesis. Margolis, B., Zilberstein, A., Franks, C., Felder, S., Kremer, S., Ullrich, A., Rhee, S.G., Skorecki, K., Schlessinger, J. Science (1990) [Pubmed]
  32. Flaujeac factor deficiency. Reconstitution with highly purified bovine high molecular weight-kininogen and delineation of a new permeability-enhancing peptide released by plasma kallikrein from bovine high molecular weight-kininogen. Matheson, R.T., Miller, D.R., Lacombe, M.J., Han, Y.N., Iwanaga, S., Kato, H., wuepper, K.D. J. Clin. Invest. (1976) [Pubmed]
  33. Systemic inhibition of the angiotensin-converting enzyme limits lipopolysaccharide-induced lung neutrophil recruitment through both bradykinin and angiotensin II-regulated pathways. Arndt, P.G., Young, S.K., Poch, K.R., Nick, J.A., Falk, S., Schrier, R.W., Worthen, G.S. J. Immunol. (2006) [Pubmed]
  34. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Martinez-Quiles, N., Rohatgi, R., Antón, I.M., Medina, M., Saville, S.P., Miki, H., Yamaguchi, H., Takenawa, T., Hartwig, J.H., Geha, R.S., Ramesh, N. Nat. Cell Biol. (2001) [Pubmed]
  35. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J., Patapoutian, A. Neuron (2004) [Pubmed]
  36. Interleukin 1 amplifies receptor-mediated activation of phospholipase A2 in 3T3 fibroblasts. Burch, R.M., Connor, J.R., Axelrod, J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  37. Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Siragy, H.M., Inagami, T., Ichiki, T., Carey, R.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  38. Different mechanisms define the antiadhesive function of high molecular weight kininogen in integrin- and urokinase receptor-dependent interactions. Chavakis, T., Kanse, S.M., Lupu, F., Hammes, H.P., Müller-Esterl, W., Pixley, R.A., Colman, R.W., Preissner, K.T. Blood (2000) [Pubmed]
  39. Kinins are generated in vivo following nasal airway challenge of allergic individuals with allergen. Proud, D., Togias, A., Naclerio, R.M., Crush, S.A., Norman, P.S., Lichtenstein, L.M. J. Clin. Invest. (1983) [Pubmed]
  40. Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture. Wong, P.Y., Talamo, R.C., Williams, G.H., Colman, R.W. J. Clin. Invest. (1975) [Pubmed]
  41. Guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate content of human umbilical artery. Clyman, R.I., Sandler, J.A., Manganiello, V.C., Vaughan, M. J. Clin. Invest. (1975) [Pubmed]
  42. In vivo targeting of inducible NO synthase with oligodeoxynucleotides protects rat kidney against ischemia. Noiri, E., Peresleni, T., Miller, F., Goligorsky, M.S. J. Clin. Invest. (1996) [Pubmed]
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