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Chemical Compound Review

Thioflavine t,CI 49005     4-(3,6-dimethylbenzothiazol- 2-yl)-N,N...

Synonyms:
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Disease relevance of Setoflavin T

 

Psychiatry related information on Setoflavin T

 

High impact information on Setoflavin T

 

Biological context of Setoflavin T

 

Anatomical context of Setoflavin T

 

Associations of Setoflavin T with other chemical compounds

 

Gene context of Setoflavin T

  • By using Thioflavin T, a dye that specifically binds to beta-sheet structures, we found that highly toxic forms of Abeta-aggregates were formed at the initial stage of fibrillogenesis, which is consistent with recent reports on Abeta oligomers [27].
  • Thioflavin T binding assays confirmed that this effect was not mediated by interference with h-IAPP oligomerization [28].
  • The fibrils have all the classical characteristics of amyloid: they have a diameter of 6-7 nm and bind both Congo red and thioflavin-T [29].
  • In addition, hARD1 forms protofilaments under physiological conditions of pH and temperature, as judged by electron microscopy and staining with the dyes Congo red and thioflavin T [30].
  • Here, we prepared nanoparticles as carriers for the model drugs thioflavin T and thioflavin S that bind fibrillar amyloid beta peptides (Abeta) [31].
 

Analytical, diagnostic and therapeutic context of Setoflavin T

References

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