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Chemical Compound Review:

Sodium-22 sodium

Synonyms: AC1O3HB1, 13966-32-0, Sodium, isotope of mass 22

Seto, S. et al., Badio, B. et al., Bizal, G.L. et al., Wixon, H.N. et al., Tokushige, A. et al., et al.

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Disease relevance of sodium

Changes in sodium-22 turnover and total body potassium in two-kidney, one-clip renovascular hypertension [1].

High impact information on sodium

Veratridine-stimulated uptake of sodium-22 in brain synaptosomes was significantly reduced by ionizing radiation over a dose range of 10 to 1000 rads [2].
Bumetanide-sensitive sodium-22 transport in vascular smooth muscle cell of the spontaneously hypertensive rat [3].
In PC12 cells with an alpha 3 beta 4(5)-nicotinic receptor, both the spiropyrrolizidine oxime 236 and nitropolyzonamine had IC50 values of about 1.5 microM, while spiropyrrolizidine oxime 222 had an IC50 value of 2.6 microM versus carbamylcholine-elicited sodium-22 influx [4].
Deglycosylation of NHE-3 with glycopeptidase F did not affect acid-stimulated, amiloride-sensitive sodium 22 influx in BBM vesicles as compared with that in controls (p > 0.05) [5].
(Blood 1982; 59: 439) for the determination of sodium-22 (22Na+) uptake in human erythrocytes [6].

Biological context of sodium

A significant negative correlation was obtained between the BHL of sodium-22 and blood pressure (r = -0.588, p less than 0.05) in hypertensive rabbits [1].

Analytical, diagnostic and therapeutic context of sodium

Changes in sodium-22 turnover and total body potassium (TBK) were studied during acute (within 2 weeks after clipping) and chronic (12-14 weeks after clipping) phases in two-kidney, one-clip (2k, 1c) hypertensive rabbits by using a whole body counter [1].
Sodium-22 influx into erythrocytes from diabetic hypertensive patients on maintenance hemodialysis [7].

References

Changes in sodium-22 turnover and total body potassium in two-kidney, one-clip renovascular hypertension. Seto, S., Kaku, T., Kuramochi, M., Hashiba, K., Okajima, S. Jpn. Circ. J. (1991) [Pubmed]
Ionizing radiation decreases veratridine-stimulated uptake of sodium in rat brain synaptosomes. Wixon, H.N., Hunt, W.A. Science (1983) [Pubmed]
Bumetanide-sensitive sodium-22 transport in vascular smooth muscle cell of the spontaneously hypertensive rat. Tokushige, A., Kino, M., Tamura, H., Hopp, L., Searle, B.M., Aviv, A. Hypertension (1986) [Pubmed]
Spiropyrrolizidines: a new class of blockers of nicotinic receptors. Badio, B., Shi, D., Shin, Y., Hutchinson, K.D., Padgett, W.L., Daly, J.W. Biochem. Pharmacol. (1996) [Pubmed]
Glycosylation of the Na+/H+ exchanger isoform NHE-3 is species specific. Bizal, G.L., Howard, R.L., Bookstein, C., Rao, M.C., Chang, E.B., Soleimani, M. J. Lab. Clin. Med. (1996) [Pubmed]
A simpler procedure to study sodium-22 uptake (ouabain insensitive) in human erythrocytes. Gambhir, K.K., Parui, R., Nerurkar, S.G., Dave, N., Mathews, J., Mehrotra, P.P., Curry, C.L. Clin. Biochem. (1988) [Pubmed]
Sodium-22 influx into erythrocytes from diabetic hypertensive patients on maintenance hemodialysis. Gambhir, K.K., Mathews, J., Parui, R., Cruz, I.A., Hosten, A.O., Dillard, M.G. Journal of the National Medical Association. (1990) [Pubmed]

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