Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Leukotriene D (5S,6R,7E,9E,11Z,14Z)-6-[2- amino-2...

Synonyms: leukotriene D4, LTD4, HMDB03080, BML1-E08, LS-72362, ...

Weiss, J.W. et al., Findlay, S.R. et al., Saengpanich, S. et al., Scott, W.A. et al.

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Disease relevance of Leukotriene D

Five normal human subjects inhaled aerosols generated from solutions of leukotriene D (LTD) to determine the bronchoconstrictor potency and the time course of airway obstruction produced by this constituent of slow-reacting substance of anaphylaxis [1].

High impact information on Leukotriene D

Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy [1].
Mechanisms of contraction induced by partially purified slow reacting substance from human polymorphonuclear leukocytes and leukotriene D in guinea pig ileal smooth muscle [2].
SRS and leukotriene D cause the generation of a slower contraction, which has a greater resistance to reversal by washing [2].
OBJECTIVE: To compare the effectiveness of an intranasal steroid treatment with that of the combination of a histamine1 receptor antagonist and a leukotriene D receptor antagonist in the treatment of seasonal allergic rhinitis [3].

Chemical compound and disease context of Leukotriene D

Leukotriene C (LTC) and its metabolites leukotriene D and leukotriene E collectively make up the biological activity known as slow-reacting substance of anaphylaxis [4].

References

Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. Weiss, J.W., Drazen, J.M., McFadden, E.R., Weller, P., Corey, E.J., Lewis, R.A., Austen, K.F. JAMA (1983) [Pubmed]
Mechanisms of contraction induced by partially purified slow reacting substance from human polymorphonuclear leukocytes and leukotriene D in guinea pig ileal smooth muscle. Findlay, S.R., Lichtenstein, L.M., Siegel, H., Triggle, D.J. J. Immunol. (1981) [Pubmed]
Fluticasone nasal spray and the combination of loratadine and montelukast in seasonal allergic rhinitis. Saengpanich, S., deTineo, M., Naclerio, R.M., Baroody, F.M. Arch. Otolaryngol. Head Neck Surg. (2003) [Pubmed]
Leukotriene C release by macrophages. Scott, W.A., Rouzer, C.A., Cohn, Z.A. Fed. Proc. (1983) [Pubmed]

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