Chemical Compound Review:
manoalide (5R)-5-hydroxy-4-[(2R,6R)-6- hydroxy-5-[(E)...
Synonyms:
CHEMBL463914, CHEBI:66666, CHEBI:562520, AC1O5NJS, DNC004112, ...
- Inhibition of crotoxin phospholipase A(2) activity by manoalide associated with inactivation of crotoxin toxicity and dissociation of the heterodimeric neurotoxic complex. Dorandeu, F., Hesters, R., Girard, F., Four, E., Foquin, A., Bon, C., Lallement, G., Faure, G. Biochem. Pharmacol. (2002)
- Modulation of superoxide anion generation by manoalide, arachidonic acid and staurosporine in liver infiltrated neutrophils in a rat model of endotoxemia. Mayer, A.M., Spitzer, J.A. J. Pharmacol. Exp. Ther. (1993)
- Role of pertussis toxin-sensitive G-proteins in intracellular Ca2+ release and apoptosis induced by inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channels in HepG2 human hepatoblastoma cells. Kim, J.A., Kang, Y.S., Lee, S.H., Lee, E.H., Lee, Y.S. J. Cell. Biochem. (2001)
- Simultaneous inhibition of renal phospholipase A(2) and glutathione synthesis by manoalide and DL-buthionine sulfoximine induces acute tubular dysfunction in rats. Soejima, A., Ishizuka, S., Miyake, N., Fukuoka, K., Suzuki, M., Kamiya, Y., Nagasawa, T. Exp. Nephrol. (2000)
- Regulation of phospholipase A2 enzymes: selective inhibitors and their pharmacological potential. Glaser, K.B. Adv. Pharmacol. (1995)
- The effects of the phospholipase A2 inhibitor, manoalide, on cartilage degradation, stromelysin expression, and synovial fluid cell count induced by intraarticular injection of human recombinant interleukin-1 alpha in the rabbit. Schrier, D.J., Flory, C.M., Finkel, M., Kuchera, S.L., Lesch, M.E., Jacobson, P.B. Arthritis Rheum. (1996)
- Regulation of CD11b/CD18 expression in human neutrophils by phospholipase A2. Jacobson, P.B., Schrier, D.J. J. Immunol. (1993)
- Botulinum toxin inhibits arachidonic acid release associated with acetylcholine release from PC12 cells. Ray, P., Berman, J.D., Middleton, W., Brendle, J. J. Biol. Chem. (1993)
- Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1. Zhang, Y.Y., Dennis, E.A. J. Biol. Chem. (1988)
- Arachidonic acid is essential for IgG Fc receptor-mediated phagocytosis by human monocytes. Lennartz, M.R., Brown, E.J. J. Immunol. (1991)
- Inhibition of phosphoinositide-specific phospholipase C by manoalide. Bennett, C.F., Mong, S., Wu, H.L., Clark, M.A., Wheeler, L., Crooke, S.T. Mol. Pharmacol. (1987)
- Manoalide: structure-activity studies and definition of the pharmacophore for phospholipase A2 inactivation. Glaser, K.B., de Carvalho, M.S., Jacobs, R.S., Kernan, M.R., Faulkner, D.J. Mol. Pharmacol. (1989)
- Phospholipase activation during monocyte adherence and spreading. Lefkowith, J.B., Lennartz, M.R., Rogers, M., Morrison, A.R., Brown, E.J. J. Immunol. (1992)
- The inhibition of release of endothelium-derived relaxant factor by manoalide, a potent inhibitor of phospholipase A2. Long, C.J., Sarau, H.M., Berkowitz, B.A. Br. J. Pharmacol. (1987)
- Manoalide, a natural sesterterpenoid that inhibits calcium channels. Wheeler, L.A., Sachs, G., De Vries, G., Goodrum, D., Woldemussie, E., Muallem, S. J. Biol. Chem. (1987)
- Manoalide. Soriente, A., De Rosa, M.M., Scettri, A., Sodano, G., Terencio, M.C., Payá, M., Alcaraz, M.J. Current medicinal chemistry. (1999)
- Regulation of eicosanoid biosynthesis in vitro and in vivo by the marine natural product manoalide: a potent inactivator of venom phospholipases. Mayer, A.M., Glaser, K.B., Jacobs, R.S. J. Pharmacol. Exp. Ther. (1988)
- Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production. Glaser, K.B., Lock, Y.W. Biochem. Pharmacol. (1995)
- Endothelin-1 stimulates the release of arachidonic acid and prostaglandins in cultured human ciliary muscle cells: activation of phospholipase A2. Yousufzai, S.Y., Abdel-latif, A.A. Exp. Eye Res. (1997)
- Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic Acid. Wong, R.K., Pettit, A.I., Quinn, P.A., Jennings, S.C., Davies, J.E., Ng, L.L. Circulation (2003)
- Phospholipase A2 activation influences the processing and secretion of the amyloid precursor protein. Emmerling, M.R., Moore, C.J., Doyle, P.D., Carroll, R.T., Davis, R.E. Biochem. Biophys. Res. Commun. (1993)
- The effects of two phospholipase A2 inhibitors on the neuromuscular blocking activities of homologous phospholipases A2 from the venom of Pseudechis australis, the Australian king brown snake. Fatehi, M., Rowan, E.G., Harvey, A.L. Toxicon (1995)