Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1O54DJ (5R,6R)-5,6-dihydroxy-1- [(2R,4S,5R)-4...

Synonyms: 42957-14-2, trans-Thymidine glycol

Wei, H. et al., Ide, H. et al.

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High impact information on cis-Thymidine glycol

Sarp A significantly decreased the TPA-induced infiltration of neutrophils, the levels of myeloperoxidase in the dermis, and the formation of H2O2, cis-thymidine glycol, 8-hydroxyl-2'-deoxyguanosine, and 5-hydroxymethyl-2'-deoxyuridine in the epidermis [1].
Alkaline phosphatase digestion of DHdTTP and dTTP-GLY gave the expected products (5,6-dihydrothymidine and cis-thymidine glycol), the identities of which were confirmed by reverse-phase HPLC using authentic markers [2].

References

Suppression of tumor promoter-induced oxidative events and DNA damage in vivo by sarcophytol A: a possible mechanism of antipromotion. Wei, H., Frenkel, K. Cancer Res. (1992) [Pubmed]
Synthesis of dihydrothymidine and thymidine glycol 5'-triphosphates and their ability to serve as substrates for Escherichia coli DNA polymerase I. Ide, H., Melamede, R.J., Wallace, S.S. Biochemistry (1987) [Pubmed]

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