Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

pppdT [hydroxy-[hydroxy- [[(2R,3S,5R)-3-hydroxy-5...

Synonyms: dTTP, Deoxy-TTP, CHEMBL363559, AG-J-07619, CHEBI:18077, ...

Perno, C.F. et al., Dakhama, A. et al., Chu, E. et al.

Chu, Callender, Farrell, Schmitz,

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Disease relevance of Deoxythymidine triphosphate

In this method, a 410-bp sequence of the human respiratory syncytial virus nucleocapsid cDNA was amplified by PCR in the presence of bromo-deoxyuridine-triphosphate, an analog of deoxythymidine-triphosphate [1].

High impact information on Deoxythymidine triphosphate

Thus, the ratio of AZT-5'-triphosphate/2'-deoxythymidine-5'-triphosphate and 2'3'-dideoxy-2'3'-didehydrothymidine-5'-triphosphate/2'-deoxythymi dine- 5'-triphosphate is several-fold higher in GM-CSF-exposed M/M, and this may account for the enhanced activity of such drugs in these cells [2].
This pathway provides the sole intracellular de novo source of 2'-deoxythymidine-5'-triphosphate; therefore, TS represents a critical target in cancer chemotherapy [3].

References

A nonradioactive method for rapid and sensitive detection of polymerase chain reaction products by use of bromo-deoxyuridine. Dakhama, A., Hegele, R.G. Mod. Pathol. (1996) [Pubmed]
Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine. Perno, C.F., Yarchoan, R., Cooney, D.A., Hartman, N.R., Webb, D.S., Hao, Z., Mitsuya, H., Johns, D.G., Broder, S. J. Exp. Med. (1989) [Pubmed]
Thymidylate synthase inhibitors as anticancer agents: from bench to bedside. Chu, E., Callender, M.A., Farrell, M.P., Schmitz, J.C. Cancer Chemother. Pharmacol. (2003) [Pubmed]

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