Chemical Compound Review:
Bicyclam 1-[[4-(1,4,8,11- tetrazacyclotetradec-1...
Synonyms:
SDZ-SID-791, AMD-3100, CHEMBL2311028, CS-0321, JM-3100, ...
This record was replaced with 65015.
- AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Donzella, G.A., Schols, D., Lin, S.W., Esté, J.A., Nagashima, K.A., Maddon, P.J., Allaway, G.P., Sakmar, T.P., Henson, G., De Clercq, E., Moore, J.P. Nat. Med. (1998)
- CXCR4 expression increases liver and lung metastasis in a mouse model of pancreatic cancer. Saur, D., Seidler, B., Schneider, G., Algül, H., Beck, R., Senekowitsch-Schmidtke, R., Schwaiger, M., Schmid, R.M. Gastroenterology (2005)
- A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Rubin, J.B., Kung, A.L., Klein, R.S., Chan, J.A., Sun, Y., Schmidt, K., Kieran, M.W., Luster, A.D., Segal, R.A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor. Esté, J.A., Cabrera, C., De Clercq, E., Struyf, S., Van Damme, J., Bridger, G., Skerlj, R.T., Abrams, M.J., Henson, G., Gutierrez, A., Clotet, B., Schols, D. Mol. Pharmacol. (1999)
- Cyclam complexes and their applications in medicine. Liang, X., Sadler, P.J. Chemical Society reviews. (2004)
- AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice. Matthys, P., Hatse, S., Vermeire, K., Wuyts, A., Bridger, G., Henson, G.W., De Clercq, E., Billiau, A., Schols, D. J. Immunol. (2001)
- Structure and dynamics of metallomacrocycles: recognition of zinc xylyl-bicyclam by an HIV coreceptor. Liang, X., Parkinson, J.A., Weishäupl, M., Gould, R.O., Paisey, S.J., Park, H.S., Hunter, T.M., Blindauer, C.A., Parsons, S., Sadler, P.J. J. Am. Chem. Soc. (2002)
- Overexpression of Both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor Proteins Predicts Early Distant Relapse in Stage II-III Colorectal Cancer Patients. Ottaiano, A., Franco, R., Aiello Talamanca, A., Liguori, G., Tatangelo, F., Delrio, P., Nasti, G., Barletta, E., Facchini, G., Daniele, B., Di Blasi, A., Napolitano, M., Ieranò, C., Calemma, R., Leonardi, E., Albino, V., Angelis, V.D., Falanga, M., Boccia, V., Capuozzo, M., Parisi, V., Botti, G., Castello, G., Vincenzo Iaffaioli, R., Scala, S. Clin. Cancer Res. (2006)
- New perspectives for the treatment of HIV infections. De Clercq, E. Verh. K. Acad. Geneeskd. Belg. (1998)
- The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication. de Vreese, K., Kofler-Mongold, V., Leutgeb, C., Weber, V., Vermeire, K., Schacht, S., Anné, J., de Clercq, E., Datema, R., Werner, G. J. Virol. (1996)
- Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers. Hendrix, C.W., Flexner, C., MacFarland, R.T., Giandomenico, C., Fuchs, E.J., Redpath, E., Bridger, G., Henson, G.W. Antimicrob. Agents Chemother. (2000)
- Strong in vitro synergy between the fusion inhibitor T-20 and the CXCR4 blocker AMD-3100. Tremblay, C.L., Kollmann, C., Giguel, F., Chou, T.C., Hirsch, M.S. J. Acquir. Immune Defic. Syndr. (2000)
- The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level. Princen, K., Hatse, S., Vermeire, K., Bridger, G.J., Skerlj, R.T., De Clercq, E., Schols, D. AIDS Res. Hum. Retroviruses (2003)
- Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5. Maeda, K., Yoshimura, K., Shibayama, S., Habashita, H., Tada, H., Sagawa, K., Miyakawa, T., Aoki, M., Fukushima, D., Mitsuya, H. J. Biol. Chem. (2001)
- CXCR4 as a functional coreceptor for human immunodeficiency virus type 1 infection of primary macrophages. Simmons, G., Reeves, J.D., McKnight, A., Dejucq, N., Hibbitts, S., Power, C.A., Aarons, E., Schols, D., De Clercq, E., Proudfoot, A.E., Clapham, P.R. J. Virol. (1998)
- Stromal cell-derived factor-1alpha modulation of the excitability of rat substantia nigra dopaminergic neurones: presynaptic mechanisms. Guyon, A., Skrzydelsi, D., Rovère, C., Rostène, W., Parsadaniantz, S.M., Nahon, J.L. J. Neurochem. (2006)
- Characterization and functionality of CXCR4 chemokine receptor and SDF-1 in human corneal fibroblasts. Bourcier, T., Berbar, T., Paquet, S., Rondeau, N., Thomas, F., Borderie, V., Laroche, L., Rostène, W., Haour, F., Lombet, A. Mol. Vis. (2003)
- Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor. Rosenkilde, M.M., Gerlach, L.O., Jakobsen, J.S., Skerlj, R.T., Bridger, G.J., Schwartz, T.W. J. Biol. Chem. (2004)
- Susceptibility of diverse primary HIV isolates with varying co-receptor specificity's to CXCR4 antagonistic compounds. Owen, S.M., Rudolph, D., Schols, D., Fujii, N., Yamamoto, N., Lal, R.B. J. Med. Virol. (2002)
- Regulation of neuronal P53 activity by CXCR 4. Khan, M.Z., Shimizu, S., Patel, J.P., Nelson, A., Le, M.T., Mullen-Przeworski, A., Brandimarti, R., Fatatis, A., Meucci, O. Mol. Cell. Neurosci. (2005)
- CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes. Nakagaki, K., Nakagaki, K., Takahashi, K., Schols, D., De Clercq, E., Tabira, T. J. Neurovirol. (2001)
- Sensitivity of human immunodeficiency virus to bicyclam derivatives is influenced by the three-dimensional structure of gp120. De Vreese, K., Van Nerum, I., Vermeire, K., Anné, J., De Clercq, E. Antimicrob. Agents Chemother. (1997)
- The emerging role of fusion inhibitors in HIV infection. De Clercq, E. Drugs in R&D. (1999)