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Chemical Compound Review

propylthiouracil     6-propyl-2-sulfanylidene-1H- pyrimidin-4-one

Synonyms: Procasil, Propacil, Propycil, Prothycil, Prothyran, ...
 
 
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Disease relevance of Tegretol

 

Psychiatry related information on Tegretol

 

High impact information on Tegretol

 

Chemical compound and disease context of Tegretol

 

Biological context of Tegretol

 

Anatomical context of Tegretol

 

Associations of Tegretol with other chemical compounds

 

Gene context of Tegretol

  • The wt and mutant D2 enzymes are essentially insensitive to propylthiouracil [concentration inhibiting 50% of activity (IC(50)) > 2 mM] in the presence of 20 mM DTT, but when tested in the presence of 0.2 mM DTT the IC(50) value for propylthiouracil is reduced to about 0.1 mM [34].
  • TR beta PV mice treated with 6-propyl-2-thiouracil and supplemented with T3 to make them euthyroid have decreased contractility with negative and positive rates of relaxation and contraction as well as peak systolic pressure diminished by 35 +/- 5, 34 +/- 6, and 35 +/- 6% in comparison with WT mice [35].
  • Compared to euthyroid thyrotrophs, the beta-1,4-galactosyltransferase mRNA level in thyrotrophs increased 440% after mice received PTU for 1 week; the mean increase within thyrotrophs over the 6-week period was 173%, whereas there was little change in corticotrophs [36].
  • During cerebellar development, an approximately 3-fold increase in the cerebellar content of ROR alpha messenger RNA (mRNA) was seen in both propylthiouracil-treated, and propylthiouracil-treated and T4-replaced animals [37].
  • Compared to euthyroid thyrotrophs, the alpha-mannosidase-II mRNA level in thyrotrophs remained unchanged while mice received PTU for 4 weeks, but then increased 150% after week 6 of PTU treatment [36].
 

Analytical, diagnostic and therapeutic context of Tegretol

References

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  33. Thyroid hormones regulate levels of thyrotropin-releasing-hormone mRNA in the paraventricular nucleus. Koller, K.J., Wolff, R.S., Warden, M.K., Zoeller, R.T. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  34. Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor. Kuiper, G.G., Klootwijk, W., Visser, T.J. Endocrinology (2002) [Pubmed]
  35. Cardiac expression and function of thyroid hormone receptor beta and its PV mutant. Swanson, E.A., Gloss, B., Belke, D.D., Kaneshige, M., Cheng, S.Y., Dillmann, W.H. Endocrinology (2003) [Pubmed]
  36. Beta-1,4-galactosyltransferase and alpha-mannosidase-II messenger ribonucleic acid levels increase with different kinetics in thyrotrophs of hypothyroid mice. Helton, T.E., Magner, J.A. Endocrinology (1994) [Pubmed]
  37. ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation. Koibuchi, N., Chin, W.W. Endocrinology (1998) [Pubmed]
  38. Inhibition of the growth of Morris hepatoma No. 44 in rats after induction of hypothyroidism: evidence that Morris hepatomas are thyroid dependent. Mishkin, S., Morris, H.P., Yalovsky, M.A., Murthy, P.V. Gastroenterology (1979) [Pubmed]
  39. Thyroid hormones in alcoholic liver disease. Effect of treatment with 6-n-propylthiouracil. Israel, Y., Walfish, P.G., Orrego, H., Blake, J., Kalant, H. Gastroenterology (1979) [Pubmed]
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