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Chemical Compound Review

Trielina     1,1,2-trichloroethene

Synonyms: Anamenth, Benzinol, Cecolene, Chorylen, Lethurin, ...
 
 
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Disease relevance of Ethinyl trichloride

 

Psychiatry related information on Ethinyl trichloride

 

High impact information on Ethinyl trichloride

 

Chemical compound and disease context of Ethinyl trichloride

 

Biological context of Ethinyl trichloride

 

Anatomical context of Ethinyl trichloride

 

Associations of Ethinyl trichloride with other chemical compounds

 

Gene context of Ethinyl trichloride

  • This contrasts with a recent report of reduced risk of RCC associated with GSTT1 null in a cohort of trichloroethene-exposed workers and suggests that specific chemical exposures alter the effect of GSTT1 on cancer risk [26].
  • Differences in cytochrome P450-catalysed oxidation of benzene, toluene and trichloroethylene (TRI) between male Wistar rats and male B6C3F1 mice were investigated by immunoblot and immunoinhibition assays using monoclonal antibodies (MAbs) to cytochrome P450 (CYP1A1/2, CYP2B1/2, CYP2E1 and CYP2C11/6) [27].
  • Taken collectively, metabolism of trichloroethylene by CYP2E1 is responsible, at least in part, for the CD4+ T cell alterations associated with exposure to this environmental toxicant [28].
  • Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding [29].
  • Although this polymorphism is limited in the case of Japanese as well as other Asian subjects, the inhibitors of ALDH2 activity such as trichloroethylene may produce a false polymorphism of this gene [30].
 

Analytical, diagnostic and therapeutic context of Ethinyl trichloride

References

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  15. 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline-induced apoptosis in the human neuroblastoma cell line SK-N-SH. Akundi, R.S., Macho, A., Muñoz, E., Lieb, K., Bringmann, G., Clement, H.W., Hüll, M., Fiebich, B.L. J. Neurochem. (2004) [Pubmed]
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  21. Review of experimental carcinogenesis by compounds related to vinyl chloride. Chu, K.C., Milman, H.A. Environ. Health Perspect. (1981) [Pubmed]
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  23. Covalent interaction of metabolites of the carcinogen trichloroethylene in rat hepatic microsomes. Van Duuren, B.L., Banerjee, S. Cancer Res. (1976) [Pubmed]
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  25. Mechanistic studies of the photocatalytic oxidation of trichloroethylene with visible-light-driven N-doped TiO2 photocatalysts. Joung, S.K., Amemiya, T., Murabayashi, M., Itoh, K. Chemistry (Weinheim an der Bergstrasse, Germany) (2006) [Pubmed]
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  28. Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice. Griffin, J.M., Gilbert, K.M., Pumford, N.R. Toxicol. Sci. (2000) [Pubmed]
  29. Exposure to a metabolite of the environmental toxicant, trichloroethylene, attenuates CD4+ T cell activation-induced cell death by metalloproteinase-dependent FasL shedding. Blossom, S.J., Gilbert, K.M. Toxicol. Sci. (2006) [Pubmed]
  30. Polymorphism of drug-metabolizing enzymes in relation to individual susceptibility to industrial chemicals. Nakajima, T., Aoyama, T. Industrial health. (2000) [Pubmed]
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