Disease relevance of Butyrine

• Dietary protein deficiency depressed branched-chain amino acids with a tendency to decreased alpha-amino-n-butyric acid [1].
• Thus, plasma branched-chain amino acids and alpha-amino-n-butyric acid in the alcoholic are affected by at least three variables: dietary protein deficiency and advanced cirrhosis which tend to decrease these amino acids, and chronic alcohol consumption which tends to increase them [1].
• Because butyrate and alpha-amino-n-butyric acid (ABA) augment gamma globin expression in normal neonatal and adult erythroid progenitors, we investigated the effects of sodium butyrate and ABA on erythroid progenitors of patients with beta thalassemia and sickle cell anemia who might benefit from such an effect [2].
• The depression in branched chain amino acids is due to multiple factors including portal-systemic shunting, hyperinsulinemia, hyperglucagonemia (all due to advanced liver disease) as well as dietary deficiency. alpha-Amino-n-butyric acid is a nonessential amino acid derived primarily from the catabolism of methionine, threonine, and serine [3].

Psychiatry related information on Butyrine

• Increased hepatic production of alpha-amino-n-butyric acid after chronic alcohol consumption in rats and baboons [4].

High impact information on Butyrine

• To study the structural and functional roles of the cysteine residues at positions 36, 41, and 46 in the transmembrane domain of phospholamban (PLB), we have used Fmoc (N-(9-fluorenyl)methoxycarbonyl) solid-phase peptide synthesis to prepare alpha-amino-n-butyric acid (Abu)-PLB, the analogue in which all three cysteine residues are replaced by Abu [5].
• Similar spectra are obtained for naturally occurring BPTI reduced by dithiothreitol, BPTI with cysteines replaced by alpha-amino-n-butyric acid, and BPTI mutant F45A reduced by dithiothreitol.(ABSTRACT TRUNCATED AT 250 WORDS)[6]
• Conversion of alpha-ketobutyrate to alpha-amino-n-butyric acid by isolated rat liver cells: effect of ethanol [7].
• Phenylalanine, tryosine, and alanine were correlated with CSF PCO2; and alpha-amino-N-butyric acid to the buffer capacity of CO2 and pH [8].
• The uptake of alpha-amino-n-butyric acid into colony-derived erythroblasts was increased in the presence of supranormal insulin [9].

Chemical compound and disease context of Butyrine

• Recent studies suggest that the ratio of plasma alpha-amino-n-butyric acid to leucine is increased specifically by chronic heavy alcohol consumption [10].

Biological context of Butyrine

• Another isomer, alpha-amino-n-butyric acid did not affect food intake or induce CTA at the tested concentrations [11].

Gene context of Butyrine

• These findings suggest that elevated levels of alpha-amino-n-butyric acid and insulin in the developing fetus delay the globin switch and may offer potential for augmenting gamma globin expression in the beta globin chain diseases [9].
• Recently developed tests that measure levels of alpha-amino-n-butyric acid (AANB) and serum glutamic dehydrogenase (GDH) may improve screening for early detection of heavy drinking and liver injury, respectively [12].

References