Chemical Compound Review:
Phenylthiourea phenylthiourea
Synonyms:
PhNHCSNH2, AC1LDWMZ, CCRIS 514, WLN: SUYZMR, P7629_ALDRICH, ...
Wooding,
Kim,
Bamshad,
Larsen,
Jorde,
Drayna,
Bartoshuk,
Duffy,
Lucchina,
Prutkin,
Fast,
Timpson,
Christensen,
Lawlor,
Gaunt,
Day,
Ebrahim,
Davey Smith,
Smith,
Crespi,
Wooding,
Bufe,
Grassi,
Howard,
Stone,
Vazquez,
Dunn,
Meyerhof,
Weiss,
Bamshad,
Tepper,
Nurse,
van Ginneken,
Ballieux,
Antonissen,
van der Linden,
Gluvers,
van den Thillart,
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- Incorporation of [125I]-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells. Broxterman, H.J., van Langevelde, A., Bakker, C.N., Boer, H., Journée-de Korver, J.G., Kaspersen, F.M., Kakebeeke-Kemme, H.M., Pauwels, E.K. Cancer Res. (1983)
- TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Timpson, N.J., Christensen, M., Lawlor, D.A., Gaunt, T.R., Day, I.N., Ebrahim, S., Davey Smith, G. Am. J. Clin. Nutr. (2005)
- Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. Smith, P.B., Crespi, C. Biochem. Pharmacol. (2002)
- Gustatory processing differences in PTC tasters and non-tasters: a reaction time analysis. Frank, R.A., Korchmar, D.L. Physiol. Behav. (1985)
- The association between phenylthiocarbamide (PTC) tasting ability and psychometric variables. Mascie-Taylor, C.G., McManus, I.C., MacLarnon, A.M., Lanigan, P.M. Behav. Genet. (1983)
- Fat perception is related to PROP taster status. Tepper, B.J., Nurse, R.J. Physiol. Behav. (1997)
- Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Wooding, S., Kim, U.K., Bamshad, M.J., Larsen, J., Jorde, L.B., Drayna, D. Am. J. Hum. Genet. (2004)
- In vitro studies of 2,4-dihydroxyphenylalanine, a prodrug targeted against malignant melanoma cells. Morrison, M.E., Yagi, M.J., Cohen, G. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Genetic characterization of the multipotent dedifferentiated state of pigmented epithelial cells in vitro. Agata, K., Kobayashi, H., Itoh, Y., Mochii, M., Sawada, K., Eguchi, G. Development (1993)
- Inhibition of L-tyrosine-induced micronuclei production by phenylthiourea in human melanoma cells. Poma, A., Bianchini, S., Miranda, M. Mutat. Res. (1999)
- PROP (6-n-propylthiouracil) supertasters and the saltiness of NaCl. Bartoshuk, L.M., Duffy, V.B., Lucchina, L.A., Prutkin, J., Fast, K. Ann. N. Y. Acad. Sci. (1998)
- Direct calorimetry of free-moving eels with manipulated thyroid status. van Ginneken, V., Ballieux, B., Antonissen, E., van der Linden, R., Gluvers, A., van den Thillart, G. Naturwissenschaften (2007)
- The action of isoproterenol on phenylthiourea induced pulmonary edema. Combs, A.B., Jones, J. Res. Commun. Chem. Pathol. Pharmacol. (1975)
- Innate immunity in insects: the role of multiple, endogenous serum lectins in the recognition of foreign invaders in the cockroach, Blaberus discoidalis. Wilson, R., Chen, C., Ratcliffe, N.A. J. Immunol. (1999)
- Tyrosinase catalyzes an unusual oxidative decarboxylation of 3,4-dihydroxymandelate. Sugumaran, M. Biochemistry (1986)
- Genetics of human taste perception. Kim, U.K., Breslin, P.A., Reed, D., Drayna, D. J. Dent. Res. (2004)
- Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Prodi, D.A., Drayna, D., Forabosco, P., Palmas, M.A., Maestrale, G.B., Piras, D., Pirastu, M., Angius, A. Chem. Senses (2004)
- In vitro analysis of cellular metaplasia from pigmented epithelial cells to lens phenotypes: a unique model system for studying cellular and molecular mechanisms of "transdifferentiation". Itoh, Y., Eguchi, G. Dev. Biol. (1986)
- The role of pigment cells in the brain of ascidian larva. Sakurai, D., Goda, M., Kohmura, Y., Horie, T., Iwamoto, H., Ohtsuki, H., Tsuda, M. J. Comp. Neurol. (2004)
- In vitro metabolism of N-(5-chloro-2-methylphenyl)-N'-(2-methylpropyl)thiourea: species comparison and identification of a novel thiocarbamide-glutathione adduct. Stevens, G.J., Hitchcock, K., Wang, Y.K., Coppola, G.M., Versace, R.W., Chin, J.A., Shapiro, M., Suwanrumpha, S., Mangold, B.L. Chem. Res. Toxicol. (1997)
- Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. Chen, M.C., Wu, S.V., Reeve, J.R., Rozengurt, E. Am. J. Physiol., Cell Physiol. (2006)
- Phenylthiourea disrupts thyroid function in developing zebrafish. Elsalini, O.A., Rohr, K.B. Dev. Genes Evol. (2003)
- Human flavin-containing monooxygenase form 2 S-oxygenation: sulfenic acid formation from thioureas and oxidation of glutathione. Henderson, M.C., Krueger, S.K., Stevens, J.F., Williams, D.E. Chem. Res. Toxicol. (2004)
- Functional Variants in TAS2R38 and TAS2R16 Influence Alcohol Consumption in High-Risk Families of African-American Origin. Wang, J.C., Hinrichs, A.L., Bertelsen, S., Stock, H., Budde, J.P., Dick, D.M., Bucholz, K.K., Rice, J., Saccone, N., Edenberg, H.J., Hesselbrock, V., Kuperman, S., Schuckit, M.A., Bierut, L.J., Goate, A.M. Alcohol. Clin. Exp. Res. (2007)
- Computational studies of ligand-receptor interactions in bitter taste receptors. Miguet, L., Zhang, Z., Grigorov, M.G. J. Recept. Signal Transduct. Res. (2006)
- Activation of tyrosinase reduces the cytotoxic effects of the superoxide anion in B16 mouse melanoma cells. Valverde, P., Manning, P., McNeil, C.J., Thody, A.J. Pigment Cell Res. (1996)
- Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol. Yukitake, J., Otake, H., Inoue, S., Wakamatsu, K., Olivares, C., Solano, F., Hasegawa, K., Ito, S. Melanoma Res. (2003)
- Degradation of tyrosinase induced by phenylthiourea occurs following Golgi maturation. Hall, A.M., Orlow, S.J. Pigment Cell Res. (2005)
- Tyrosinase isozyme heterogeneity in differentiating B16/C3 melanoma. Laskin, J.D., Piccinini, L.A. J. Biol. Chem. (1986)
- Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Wooding, S., Bufe, B., Grassi, C., Howard, M.T., Stone, A.C., Vazquez, M., Dunn, D.M., Meyerhof, W., Weiss, R.B., Bamshad, M.J. Nature (2006)
- Structure-activity relationships defining the cytotoxicity of catechol analogues against human malignant melanoma. Kern, D.H., Shoemaker, R.H., Hildebrand-Zanki, S.U., Driscoll, J.S. Cancer Res. (1988)
- Skin organ culture model for examining epidermal melanization. Imokawa, G., Motegi, I. J. Invest. Dermatol. (1993)
- The influence of phenylthiourea (PTU) on the pigment epithelium and the photoreceptor cells in the developing retina of Haplochromis burtoni (Cichlidae, Teleostei). Pietzsch-Rohrschneider, I. Cell Tissue Res. (1977)
- Phenylthiourea enhances Cu cytotoxicity in cell cultures: its mode of action. Masuda, A., Eguchi, G. Cell Struct. Funct. (1984)
- Effect of high altitude on sensitivity to the taste of phenylthiocarbamide. Singh, S.B., Chatterjee, A., Panjwani, U., Yadav, D.K., Selvamurthy, W., Sharma, K.N. International journal of biometeorology. (2000)
- Existence of phenol oxidase in the argasid tick Ornithodoros moubata. Kadota, K., Satoh, E., Ochiai, M., Inoue, N., Tsuji, N., Igarashi, I., Nagasawa, H., Mikami, T., Claveria, F.G., Fujisaki, K. Parasitol. Res. (2002)