Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

F9108_ALDRICH 5-fluoro-1H-indole

Synonyms: CHEMBL555457, NSC-88613, AC-2259, CHEBI:654504, NSC88613, ...

Barczak, A.J. et al., Radwanski, E.R. et al.

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High impact information on NSC88613

5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana [1].
Three mutations in the Arabidopsis thaliana gene encoding the alpha subunit of tryptophan synthase were isolated by selection for resistance to 5-methylanthranilate or 5-fluoroindole, toxic analogs of tryptophan pathway intermediates [2].

Biological context of NSC88613

A study of the biochemical genetics of the Arabidopsis thaliana tryptophan synthase beta subunit was initiated by characterization of mutants resistant to the inhibitor 5-fluoroindole [1].

References

5-Fluoroindole resistance identifies tryptophan synthase beta subunit mutants in Arabidopsis thaliana. Barczak, A.J., Zhao, J., Pruitt, K.D., Last, R.L. Genetics (1995) [Pubmed]
Characterization of tryptophan synthase alpha subunit mutants of Arabidopsis thaliana. Radwanski, E.R., Barczak, A.J., Last, R.L. Mol. Gen. Genet. (1996) [Pubmed]

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