Disease relevance of NSC 24500

• In all cases of contact dermatitis from these wood species in which quinoid allergens other than 2,6-dimethoxybenzoquinone could be detected, this quinone should be used for patch tests [1].
• Among these compounds, 2,6-dimethoxy-p-benzoquinone showed a very weak and questionable mutagenic activity against Salmonella typhimurium TA 100 [2].
• Previous electron spin resonance studies have demonstrated that the decay of ascorbyl plus semiquinone radicals, produced in an aqueous mixture of ascorbate and 2,6-dimethoxy-p-quinone, is accelerated by ascites cells [3].

High impact information on NSC 24500

• We prepared a normalized, subtractive cDNA library enriched for transcripts differentially abundant in T. versicolor root tips treated with the allelopathic quinone 2,6-dimethoxybenzoquinone (DMBQ) [4].
• The ability of 2,6-dimethoxyquinone (DMQ) to impair 86Rb uptake by bovine lens epithelial cells was found to be independent of exogenous ascorbate in contrast to the impairment induced by Fe/Cu or riboflavin plus light [5].
• Inhibition of mast cell histamine release by 2,6-dimethoxy-p-benzoquinone isolated from Berchemia racemosa [6].
• Fully reversible redox cycling of 2,6-dimethoxy-1,4-benzoquinone induced by ascorbate [7].

References