Chemical Compound Review:
AC1OAGKB (2R)-2-[[[(2S,3R,5S,6S)-2,6- dihydroxy-3,4...
Synonyms:
- PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Radu, A., Neubauer, V., Akagi, T., Hanafusa, H., Georgescu, M.M. Mol. Cell. Biol. (2003)
- The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha. Turner, S.J., Domin, J., Waterfield, M.D., Ward, S.G., Westwick, J. J. Biol. Chem. (1998)
- Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin. Chellaiah, M.A., Biswas, R.S., Yuen, D., Alvarez, U.M., Hruska, K.A. J. Biol. Chem. (2001)
- Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. Batty, I.H., Downes, C.P. Biochem. J. (1996)
- Disturbed granulocyte macrophage-colony stimulating factor priming of phosphatidylinositol 3,4,5-trisphosphate accumulation and Rac activation in fMLP-stimulated neutrophils from patients with myelodysplasia. Fuhler, G.M., Cadwallader, K.A., Knol, G.J., Chilvers, E.R., Drayer, A.L., Vellenga, E. J. Leukoc. Biol. (2004)
- Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Backman, S.A., Stambolic, V., Suzuki, A., Haight, J., Elia, A., Pretorius, J., Tsao, M.S., Shannon, P., Bolon, B., Ivy, G.O., Mak, T.W. Nat. Genet. (2001)
- SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Shinohara, M., Terada, Y., Iwamatsu, A., Shinohara, A., Mochizuki, N., Higuchi, M., Gotoh, Y., Ihara, S., Nagata, S., Itoh, H., Fukui, Y., Jessberger, R. Nature (2002)
- Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Hirsch, E., Katanaev, V.L., Garlanda, C., Azzolino, O., Pirola, L., Silengo, L., Sozzani, S., Mantovani, A., Altruda, F., Wymann, M.P. Science (2000)
- Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G.F., Holmes, A.B., Gaffney, P.R., Reese, C.B., McCormick, F., Tempst, P., Coadwell, J., Hawkins, P.T. Science (1998)
- Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Stokoe, D., Stephens, L.R., Copeland, T., Gaffney, P.R., Reese, C.B., Painter, G.F., Holmes, A.B., McCormick, F., Hawkins, P.T. Science (1997)
- Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Goberdhan, D.C., Paricio, N., Goodman, E.C., Mlodzik, M., Wilson, C. Genes Dev. (1999)
- Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Anzelon, A.N., Wu, H., Rickert, R.C. Nat. Immunol. (2003)
- Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. Singh, V.P., Saluja, A.K., Bhagat, L., van Acker, G.J., Song, A.M., Soltoff, S.P., Cantley, L.C., Steer, M.L. J. Clin. Invest. (2001)
- Leading-edge research: PtdIns(3,4,5)P(3) and directed migration. Franca-Koh, J., Kamimura, Y., Devreotes, P.N. Nat. Cell Biol. (2007)
- Control of cell polarity and motility by the PtdIns(3,4,5)P(3) phosphatase SHIP1. Nishio, M., Watanabe, K., Sasaki, J., Taya, C., Takasuga, S., Iizuka, R., Balla, T., Yamazaki, M., Watanabe, H., Itoh, R., Kuroda, S., Horie, Y., F??rster, I., Mak, T.W., Yonekawa, H., Penninger, J.M., Kanaho, Y., Suzuki, A., Sasaki, T. Nat. Cell Biol. (2007)
- Roles of Rho-family GTPases in cell polarisation and directional migration. Fukata, M., Nakagawa, M., Kaibuchi, K. Curr. Opin. Cell Biol. (2003)
- BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Okada, T., Maeda, A., Iwamatsu, A., Gotoh, K., Kurosaki, T. Immunity (2000)
- Imaging antigen-induced PI3K activation in T cells. Harriague, J., Bismuth, G. Nat. Immunol. (2002)
- CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly. Jones, R.G., Elford, A.R., Parsons, M.J., Wu, L., Krawczyk, C.M., Yeh, W.C., Hakem, R., Rottapel, R., Woodgett, J.R., Ohashi, P.S. J. Exp. Med. (2002)
- Phosphatidylinositol-3,4,5-trisphosphate regulates the formation of the basolateral plasma membrane in epithelial cells. Gassama-Diagne, A., Yu, W., ter Beest, M., Martin-Belmonte, F., Kierbel, A., Engel, J., Mostov, K. Nat. Cell Biol. (2006)
- BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity. Saito, K., Tolias, K.F., Saci, A., Koon, H.B., Humphries, L.A., Scharenberg, A., Rawlings, D.J., Kinet, J.P., Carpenter, C.L. Immunity (2003)
- Phosphoinositide signaling plays a key role in cytokinesis. Janetopoulos, C., Devreotes, P. J. Cell Biol. (2006)
- Phosphoinositides and phagocytosis. Gillooly, D.J., Simonsen, A., Stenmark, H. J. Cell Biol. (2001)
- Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals. Scharenberg, A.M., El-Hillal, O., Fruman, D.A., Beitz, L.O., Li, Z., Lin, S., Gout, I., Cantley, L.C., Rawlings, D.J., Kinet, J.P. EMBO J. (1998)
- Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. Maffucci, T., Brancaccio, A., Piccolo, E., Stein, R.C., Falasca, M. EMBO J. (2003)
- Targeted disruption of SHIP leads to Steel factor-induced degranulation of mast cells. Huber, M., Helgason, C.D., Scheid, M.P., Duronio, V., Humphries, R.K., Krystal, G. EMBO J. (1998)
- Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Oganesian, A., Poot, M., Daum, G., Coats, S.A., Wright, M.B., Seifert, R.A., Bowen-Pope, D.F. Proc. Natl. Acad. Sci. U.S.A. (2003)
- PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Ma, R., Li, W.P., Rundle, D., Kong, J., Akbarali, H.I., Tsiokas, L. Mol. Cell. Biol. (2005)
- Novel functional PI 3-kinase antagonists inhibit cell growth and tumorigenicity in human cancer cell lines. Razzini, G., Berrie, C.P., Vignati, S., Broggini, M., Mascetta, G., Brancaccio, A., Falasca, M. FASEB J. (2000)
- Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cells. DeWald, D.B., Torabinejad, J., Samant, R.S., Johnston, D., Erin, N., Shope, J.C., Xie, Y., Welch, D.R. Cancer Res. (2005)
- Purification and biochemical characterization of a mammalian phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase. Woscholski, R., Waterfield, M.D., Parker, P.J. J. Biol. Chem. (1995)
- The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes. Nakashima, N., Sharma, P.M., Imamura, T., Bookstein, R., Olefsky, J.M. J. Biol. Chem. (2000)
- Antibody ligation of CD7 leads to association with phosphoinositide 3-kinase and phosphatidylinositol 3,4,5-trisphosphate formation in T lymphocytes. Ward, S.G., Parry, R., LeFeuvre, C., Sansom, D.M., Westwick, J., Lazarovits, A.I. Eur. J. Immunol. (1995)
- Activation of phosphoinositide 3-kinase and Src family kinase is required for respiratory burst in rat neutrophils stimulated with artocarpol A. Kuan, Y.H., Lin, R.H., Lin, H.Y., Huang, L.J., Tsai, C.R., Tsao, L.T., Lin, C.N., Chang, L.C., Wang, J.P. Biochem. Pharmacol. (2006)