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Chemical Compound Review

THIQ 6     1,2,3,4-tetrahydroisoquinoline

Synonyms: PubChem7253, CHEMBL14346, SureCN19085, T13005_ALDRICH, AG-H-74159, ...
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Disease relevance of Tetrahydroisoquinoline


Psychiatry related information on Tetrahydroisoquinoline


High impact information on Tetrahydroisoquinoline


Chemical compound and disease context of Tetrahydroisoquinoline


Biological context of Tetrahydroisoquinoline


Anatomical context of Tetrahydroisoquinoline


Associations of Tetrahydroisoquinoline with other chemical compounds


Gene context of Tetrahydroisoquinoline


Analytical, diagnostic and therapeutic context of Tetrahydroisoquinoline


  1. Accumulation of a tetrahydroisoquinoline in phenylketonuria. Lasala, J.M., Coscia, C.J. Science (1979) [Pubmed]
  2. Cytochrome P450 isozymes catalyzing 4-hydroxylation of parkinsonism-related compound 1,2,3,4-tetrahydroisoquinoline in rat liver microsomes. Suzuki, T., Fujita, S., Narimatsu, S., Masubuchi, Y., Tachibana, M., Ohta, S., Hirobe, M. FASEB J. (1992) [Pubmed]
  3. Evaluation of neurotoxicity of TIQ and MPTP and of parkinsonism-preventing effect of 1-MeTIQ by in vivo measurement of pre-synaptic dopamine transporters and post-synaptic dopamine D(2) receptors in the mouse striatum. Ishiwata, K., Koyanagi, Y., Abe, K., Kawamura, K., Taguchi, K., Saitoh, T., Toda, J., Senda, M., Sano, T. J. Neurochem. (2001) [Pubmed]
  4. Novel multidrug resistance reversal agents. Berger, D., Citarella, R., Dutia, M., Greenberger, L., Hallett, W., Paul, R., Powell, D. J. Med. Chem. (1999) [Pubmed]
  5. Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. Mohler, M.L., Kang, G.S., Hong, S.S., Patil, R., Kirichenko, O.V., Li, W., Rakov, I.M., Geisert, E.E., Miller, D.D. J. Med. Chem. (2006) [Pubmed]
  6. Kainic acid lesioning of alkaloid-sensitive brain sites and ethanol ingestion in the rat. Swartzwelder, H.S., Myers, R.D. Neurosci. Lett. (1983) [Pubmed]
  7. Stimulus properties of PMMA: effect of optical isomers and conformational restriction. Young, R., Dukat, M., Malmusi, L., Glennon, R.A. Pharmacol. Biochem. Behav. (1999) [Pubmed]
  8. Oxidative DNA damage and cytotoxicity induced by copper-stimulated redox cycling of salsolinol, a neurotoxic tetrahydroisoquinoline alkaloid. Jung, Y., Surh, Y. Free Radic. Biol. Med. (2001) [Pubmed]
  9. 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Tsu, H., Chen, X., Chen, C.T., Lee, S.J., Chang, C.N., Kao, K.H., Coumar, M.S., Yeh, Y.T., Chien, C.H., Wang, H.S., Lin, K.T., Chang, Y.Y., Wu, S.H., Chen, Y.S., Lu, I.L., Wu, S.Y., Tsai, T.Y., Chen, W.C., Hsieh, H.P., Chao, Y.S., Jiaang, W.T. J. Med. Chem. (2006) [Pubmed]
  10. Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. Renaud, J., Bischoff, S.F., Buhl, T., Floersheim, P., Fournier, B., Geiser, M., Halleux, C., Kallen, J., Keller, H., Ramage, P. J. Med. Chem. (2005) [Pubmed]
  11. Synthesis and structure-activity relationships of novel selective factor Xa inhibitors with a tetrahydroisoquinoline ring. Ueno, H., Yokota, K., Hoshi, J., Yasue, K., Hayashi, M., Hase, Y., Uchida, I., Aisaka, K., Katoh, S., Cho, H. J. Med. Chem. (2005) [Pubmed]
  12. Differential cell death induced by salsolinol with and without copper: possible role of reactive oxygen species. Kim, H.J., Soh, Y., Jang, J.H., Lee, J.S., Oh, Y.J., Surh, Y.J. Mol. Pharmacol. (2001) [Pubmed]
  13. Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism. Kawai, H., Makino, Y., Hirobe, M., Ohta, S. J. Neurochem. (1998) [Pubmed]
  14. Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine in the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats. Lorenc-Koci, E., Smiałowska, M., Antkiewicz-Michaluk, L., Gołembiowska, K., Bajkowska, M., Wolfarth, S. Neuroscience (2000) [Pubmed]
  15. Novel toxins and Parkinson's disease: N-methylation and oxidation as metabolic bioactivation of neurotoxin. Naoi, M., Maruyama, W., Niwa, T., Nagatsu, T. J. Neural Transm. Suppl. (1994) [Pubmed]
  16. Synthesis and radioligand binding studies of C-5- and C-8-substituted 1-(3,4-dimethoxybenzyl)-2,2-dimethyl-1,2,3,4-tetrahydroisoquinoliniums as SK channel blockers related to N-methyl-laudanosine and N-methyl-noscapine. Graulich, A., Scuvée-Moreau, J., Seutin, V., Liégeois, J.F. J. Med. Chem. (2005) [Pubmed]
  17. Enantioselective total syntheses of the Ipecacuanha alkaloid emetine, the Alangium alkaloid tubulosine and a novel benzoquinolizidine alkaloid by using a domino process. Tietze, L.F., Rackelmann, N., Müller, I. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  18. Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine. Fishlock, D., Williams, R.M. Org. Lett. (2006) [Pubmed]
  19. Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). McNaught, K.S., Thull, U., Carrupt, P.A., Altomare, C., Cellamare, S., Carotti, A., Testa, B., Jenner, P., Marsden, C.D. Biochem. Pharmacol. (1995) [Pubmed]
  20. Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline. Suzuki, K., Mizuno, Y., Yoshida, M. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
  21. Interaction of catecholamine-derived alkaloids with central neurotransmitter receptors. Nimit, Y., Schulze, I., Cashaw, J.L., Ruchirawat, S., Davis, V.E. J. Neurosci. Res. (1983) [Pubmed]
  22. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Seaton, T.A., Cooper, J.M., Schapira, A.H. Brain Res. (1998) [Pubmed]
  23. Hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens. Costall, B., Naylor, R.J., Pinder, R.M. Eur. J. Pharmacol. (1976) [Pubmed]
  24. Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline. Suzuki, K., Mizuno, Y., Yoshida, M. Neurosci. Lett. (1988) [Pubmed]
  25. Synthesis and pharmacological evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and related analogues as a new class of specific bradycardic agents possessing I(f) channel inhibitory activity. Kubota, H., Kakefuda, A., Watanabe, T., Ishii, N., Wada, K., Masuda, N., Sakamoto, S., Tsukamoto, S. J. Med. Chem. (2003) [Pubmed]
  26. New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". Mutulis, F., Yahorava, S., Mutule, I., Yahorau, A., Liepinsh, E., Kopantshuk, S., Veiksina, S., Tars, K., Belyakov, S., Mishnev, A., Rinken, A., Wikberg, J.E. J. Med. Chem. (2004) [Pubmed]
  27. Multicenter double-blind comparison of nomifensine and imipramine for efficacy and safety in depressed outpatients. Bremner, J.D., Abrahams, L.M., Crupie, J.E., McCawley, A., Proctor, R.C., Sathananthan, G.L. The Journal of clinical psychiatry. (1984) [Pubmed]
  28. Coenzyme--substrate adducts as inhibitors of mouse liver 3,4-dihydroxyphenylalanine decarboxylase. Rudd, E.A., Cunningham, W.C., Thanassi, J.W. J. Med. Chem. (1979) [Pubmed]
  29. Molecular cloning of mouse liver flavin containing monooxygenase (FMO1) cDNA and characterization of the expression product: metabolism of the neurotoxin, 1,2,3,4-tetrahydroisoquinoline (TIQ). Itoh, K., Nakamura, K., Kimura, T., Itoh, S., Kamataki, T. The Journal of toxicological sciences. (1997) [Pubmed]
  30. Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. Grunewald, G.L., Sall, D.J., Monn, J.A. J. Med. Chem. (1988) [Pubmed]
  31. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. Grunewald, G.L., Caldwell, T.M., Li, Q., Criscione, K.R. J. Med. Chem. (1999) [Pubmed]
  32. 3-(omega-Aminoalkyl)-5,5-dialkyl(or spirocycloalkyl-1',5-)hydantoins as new 5-HT1A and 5-HT2A receptor ligands. Byrtus, H., Pawłowski, M., Charakchieva-Minol, S., Duszyńska, B., Mokrosz, M.J., Mokrosz, J.L., Zejc, A. Arch. Pharm. (Weinheim) (1996) [Pubmed]
  33. Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline. Shimma, N., Akiyama, N., Umezawa, M., Okuma, Y., Nomura, Y., Saito, T., Horie, S., Murayama, T. J. Pharmacol. Sci. (2003) [Pubmed]
  34. Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743. Minuzzo, M., Marchini, S., Broggini, M., Faircloth, G., D'Incalci, M., Mantovani, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  35. Determination of tetrahydroisoquinoline alkaloids in biological materials with high performance liquid chromatography. Riggin, R.M., Kissinger, P.T. Anal. Chem. (1977) [Pubmed]
  36. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Erba, E., Bergamaschi, D., Bassano, L., Damia, G., Ronzoni, S., Faircloth, G.T., D'Incalci, M. Eur. J. Cancer (2001) [Pubmed]
  37. Regulation of dopamine D1 receptors by chronic administration of structurally different D1 receptor antagonists: a quantitative autoradiographic study. Lappalainen, J., Hietala, J., Pohjalainen, T., Syvälahti, E. Eur. J. Pharmacol. (1992) [Pubmed]
  38. Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro. Donald, S., Verschoyle, R.D., Greaves, P., Orr, S., Jimeno, J., Gescher, A.J. Cancer Chemother. Pharmacol. (2004) [Pubmed]
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