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Chemical Compound Review

THIQ 6     1,2,3,4-tetrahydroisoquinoline

Synonyms: PubChem7253, CHEMBL14346, SureCN19085, T13005_ALDRICH, AG-H-74159, ...
 
 
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Disease relevance of Tetrahydroisoquinoline

 

Psychiatry related information on Tetrahydroisoquinoline

 

High impact information on Tetrahydroisoquinoline

 

Chemical compound and disease context of Tetrahydroisoquinoline

 

Biological context of Tetrahydroisoquinoline

 

Anatomical context of Tetrahydroisoquinoline

 

Associations of Tetrahydroisoquinoline with other chemical compounds

 

Gene context of Tetrahydroisoquinoline

 

Analytical, diagnostic and therapeutic context of Tetrahydroisoquinoline

References

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  9. 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Tsu, H., Chen, X., Chen, C.T., Lee, S.J., Chang, C.N., Kao, K.H., Coumar, M.S., Yeh, Y.T., Chien, C.H., Wang, H.S., Lin, K.T., Chang, Y.Y., Wu, S.H., Chen, Y.S., Lu, I.L., Wu, S.Y., Tsai, T.Y., Chen, W.C., Hsieh, H.P., Chao, Y.S., Jiaang, W.T. J. Med. Chem. (2006) [Pubmed]
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  24. Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline. Suzuki, K., Mizuno, Y., Yoshida, M. Neurosci. Lett. (1988) [Pubmed]
  25. Synthesis and pharmacological evaluation of 1-oxo-2-(3-piperidyl)-1,2,3,4- tetrahydroisoquinolines and related analogues as a new class of specific bradycardic agents possessing I(f) channel inhibitory activity. Kubota, H., Kakefuda, A., Watanabe, T., Ishii, N., Wada, K., Masuda, N., Sakamoto, S., Tsukamoto, S. J. Med. Chem. (2003) [Pubmed]
  26. New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of "THIQ". Mutulis, F., Yahorava, S., Mutule, I., Yahorau, A., Liepinsh, E., Kopantshuk, S., Veiksina, S., Tars, K., Belyakov, S., Mishnev, A., Rinken, A., Wikberg, J.E. J. Med. Chem. (2004) [Pubmed]
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  30. Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. Grunewald, G.L., Sall, D.J., Monn, J.A. J. Med. Chem. (1988) [Pubmed]
  31. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor. Grunewald, G.L., Caldwell, T.M., Li, Q., Criscione, K.R. J. Med. Chem. (1999) [Pubmed]
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  38. Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro. Donald, S., Verschoyle, R.D., Greaves, P., Orr, S., Jimeno, J., Gescher, A.J. Cancer Chemother. Pharmacol. (2004) [Pubmed]
 
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