The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Immusine     3-amino-9-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: Immunosine, Satoribine, Isatoribine, ANA-245, ANA245, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Isatoribine


High impact information on Isatoribine


Analytical, diagnostic and therapeutic context of Isatoribine

  • Interferon induction appears to be the reason for antiviral activity in this model, since up to 10,000 units of interferon/ml were induced in mice 1 h after treatment with 100 mg 7-thia-8-oxoguanosine per kg, and antibody to interferon alpha/beta administered shortly after treatment with the nucleoside negated the antiviral effect [8].


  1. Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Horsmans, Y., Berg, T., Desager, J.P., Mueller, T., Schott, E., Fletcher, S.P., Steffy, K.R., Bauman, L.A., Kerr, B.M., Averett, D.R. Hepatology (2005) [Pubmed]
  2. Direct C-glycosylation of guanine analogues: the synthesis and antiviral activity of certain 7- and 9-deazaguanine C-nucleosides. Girgis, N.S., Michael, M.A., Smee, D.F., Alaghamandan, H.A., Robins, R.K., Cottam, H.B. J. Med. Chem. (1990) [Pubmed]
  3. Potentiation of the efficacy of murine L1210 leukemia vaccine by a novel immunostimulator 7-thia-8-oxoguanosine: increased survival after immunization with vaccine plus 7-thia-8-oxoguanosine. Sharma, B.S., Balazs, L., Jin, A., Wang, J.C., Jolley, W.B., Robins, R.K. Cancer Immunol. Immunother. (1991) [Pubmed]
  4. Immunomodulatory activity of a novel nucleoside, 7-thia-8-oxoguanosine: I. Activation of natural killer cells in mice. Sharma, B.S., Mhaskar, S., Balazs, L., Siaw, M. Immunopharmacology and immunotoxicology. (1992) [Pubmed]
  5. Successful immunotherapy of murine melanoma metastases with 7-thia-8-oxoguanosine. Sharma, B.S., Balazs, L., Jin, A., Jolley, W.B., Robins, R.K. Clin. Exp. Metastasis (1991) [Pubmed]
  6. Broad-spectrum in vivo antiviral activity of 7-thia-8-oxoguanosine, a novel immunopotentiating agent. Smee, D.F., Alaghamandan, H.A., Cottam, H.B., Sharma, B.S., Jolley, W.B., Robins, R.K. Antimicrob. Agents Chemother. (1989) [Pubmed]
  7. Immunosine (7-thia-8-oxoguanosine) acts as a cofactor for proliferation of T cells. Colić, M., Jandrić, D., Gasić, S., Vucević, D., Popović, P., Medić-Mijacević, L., Rakić, L. Fundamental & clinical pharmacology. (2000) [Pubmed]
  8. Prophylactic and therapeutic activities of 7-thia-8-oxoguanosine against Punta Toro virus infections in mice. Smee, D.F., Huffman, J.H., Gessaman, A.C., Huggins, J.W., Sidwell, R.W. Antiviral Res. (1991) [Pubmed]
WikiGenes - Universities