Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Diphos 2-diphenylphosphanylethyl- diphenyl-phosphane

Synonyms: CHEMBL68683, AG-E-15847, CHEBI:30669, NSC-76285, AC-4965, ...

Ellis, D.D. et al., Kamijo, S. et al., Sanghamitra, N.J. et al., Hoke, G.D. et al.

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Disease relevance of Diphos

In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane [1].

High impact information on Diphos

The palladium-catalyzed three-component coupling reaction (TCCR) of aryl isocyanides, allyl methyl carbonate, and trimethylsilyl azide was conducted in the presence of Pd(2)(dba)(3).CHCl(3) (2.5 mol %) and dppe (1,2-bis(diphenylphosphino)ethane) (10 mol %) [2].
We have synthesized a series of copper(I) complexes of 1,2-bis(diphenylphosphino)ethane (DPPE) and tested their in vitro cytotoxicity in a human lung carcinoma cell line H460 [3].

Analytical, diagnostic and therapeutic context of Diphos

The rhenacarborane salt Cs[Re(CO)3(eta5-7,8-C2B9H11)] (1) has been used to synthesize the tetranuclear metal complex [[ReAg(mu-10-H-eta5-7,8-C2B9H10)(CO)3]2[mu-Ph2P(CH2)2PPh2]] (3) where two [ReAg(mu-10-H-eta5-7,8-C2B9H10)(CO)3] fragments have been shown by X-ray crystallography to be bridged by a single 1,2-bis(diphenylphosphino)ethane ligand [4].

References

In vivo development and in vitro characterization of a subclone of murine P388 leukemia resistant to bis(diphenylphosphine)ethane. Hoke, G.D., McCabe, F.L., Faucette, L.F., Bartus, J.O., Sung, C.M., Jensen, B.D., Heys, J.R., Rush, G.F., Alberts, D.W., Johnson, R.K. Mol. Pharmacol. (1991) [Pubmed]
Synthesis of allyl cyanamides and N-cyanoindoles via the palladium-catalyzed three-component coupling reaction. Kamijo, S., Yamamoto, Y. J. Am. Chem. Soc. (2002) [Pubmed]
Mechanism of cytotoxicity of copper(I) complexes of 1,2-bis(diphenylphosphino)ethane. Sanghamitra, N.J., Phatak, P., Das, S., Samuelson, A.G., Somasundaram, K. J. Med. Chem. (2005) [Pubmed]
Silver as an exopolyhedral auxiliary to the rhenacarborane anion [Re(CO)3(eta5-7,8-C2B9H11)]-. Ellis, D.D., Jeffery, J.C., Jelliss, P.A., Kautz, J.A., Stone, F.G. Inorganic chemistry. (2001) [Pubmed]

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