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Chemical Compound Review

Z-LYSINE     (2S)-6-amino-2- phenylmethoxycarbonylamino...

Synonyms: Z-Lys-OH, Cbz-Lys-OH, Z-L-LYSINE, CBZ-L-LYSINE, Z-L-LYS-OH, ...
 
 
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High impact information on N-alpha-Benzyloxycarbonyl-L-lysine

 

Biological context of N-alpha-Benzyloxycarbonyl-L-lysine

 

Anatomical context of N-alpha-Benzyloxycarbonyl-L-lysine

 

Associations of N-alpha-Benzyloxycarbonyl-L-lysine with other chemical compounds

  • The PEL blasts, in contrast to PEL, possess massive quantities of lytic granules, and protease (N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester esterase) (BLT-esterase) activity as well as non-specific, cell-mediated cytolytic activity in a long term (4-h) assay [12].
  • Transmembrane chloride flux is required for target cell lysis but not for Golgi reorientation in cloned cytolytic effector cells. Golgi reorientation, N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase release, and delivery of the lethal hit are separable events in target cell lysis [13].
 

Gene context of N-alpha-Benzyloxycarbonyl-L-lysine

References

  1. High activity of N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and cytolytic perforin in cloned cell lines is not demonstrable in in-vivo-induced cytotoxic effector cells. Dennert, G., Anderson, C.G., Prochazka, G. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes. Brown, G.R., Meek, K., Nishioka, Y., Thiele, D.L. J. Immunol. (1995) [Pubmed]
  3. Nongranular proteolytic enzymes of rat IL-2-activated natural killer cells. I. Subcellular localization and functional role. Goldfarb, R.H., Wasserman, K., Herberman, R.B., Kitson, R.P. J. Immunol. (1992) [Pubmed]
  4. Cytotoxic activity and lymphokine production of T cell receptor (TCR)-alpha beta+ and TCR-gamma delta+ cytotoxic T lymphocyte (CTL) clones recognizing HLA-A2 and HLA-A2 mutants. Recognition of TCR-gamma delta+ CTL clones is affected by mutations at positions 152 and 156. Spits, H., Paliard, X., Engelhard, V.H., de Vries, J.E. J. Immunol. (1990) [Pubmed]
  5. Chemical synthesis and papain-catalysed hydrolysis of N-alpha-benzyloxycarbonyl-L-lysine p-nitroanilide. Mackenzie, N.E., Malthouse, J.P., Scott, A.I. Biochem. J. (1985) [Pubmed]
  6. Cryoenzymology of trypsin. 13C-n.m.r. detection of an acyl-trypsin intermediate in the trypsin-catalysed hydrolysis of a highly specific substrate at subzero temperature. Mackenzie, N.E., Malthouse, J.P., Scott, A.I. Biochem. J. (1984) [Pubmed]
  7. Effect of calcium ions on enteropeptidase catalysis. Mikhailova, A.G., Likhareva, V.V., Prudchenko, I.A., Rumsh, L.D. Biochemistry Mosc. (2005) [Pubmed]
  8. T helper cell cytoplasmic granules. Exocytosis in response to activation via the T cell receptor. Taplits, M.S., Henkart, P.A., Hodes, R.J. J. Immunol. (1988) [Pubmed]
  9. Antigen-specific, but not natural killer, activity of T cell receptor-gamma delta cytotoxic T lymphocyte clones involves secretion of N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase and influx of Ca2+ ions. Spits, H., Paliard, X., De Vries, J.E. J. Immunol. (1989) [Pubmed]
  10. Expression of cytoplasmic granules with T cell-associated serine proteinase-1 activity in Ly-2+(CD8+) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo. Kramer, M.D., Fruth, U., Simon, H.G., Simon, M.M. Eur. J. Immunol. (1989) [Pubmed]
  11. Swainsonine augments the cytotoxicity of human lymphokine-activated killer cells against autologous thyroid cancer cells. Fujieda, S., Noda, I., Saito, H., Hoshino, T., Yagita, M. Arch. Otolaryngol. Head Neck Surg. (1994) [Pubmed]
  12. Highly lytic in vivo primed cytolytic T lymphocytes devoid of lytic granules and BLT-esterase activity acquire these constituents in the presence of T cell growth factors upon blast transformation in vitro. Berke, G., Rosen, D. J. Immunol. (1988) [Pubmed]
  13. Transmembrane chloride flux is required for target cell lysis but not for Golgi reorientation in cloned cytolytic effector cells. Golgi reorientation, N alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester serine esterase release, and delivery of the lethal hit are separable events in target cell lysis. Prochazka, G., Landon, C., Dennert, G. J. Immunol. (1988) [Pubmed]
  14. Induction of perforin and serine esterases in a murine cytotoxic T lymphocyte clone. Liu, C.C., Joag, S.V., Kwon, B.S., Young, J.D. J. Immunol. (1990) [Pubmed]
  15. Activity of granzyme A, a serine protease in the killing granules of cytotoxic T lymphocytes, is reduced in cells from HIV-infected hemophiliacs. Chiang, C.F., Tenenbaum, S.A., Verret, C.R., Leissinger, C.A., Garry, R.F. AIDS Res. Hum. Retroviruses (1996) [Pubmed]
  16. Non-granular proteolytic enzymes of rat interleukin-2-activated natural killer cells. III. Enhancement of A-NKP 1, 2, and 3 proteolytic activities (cleaving after Arg, Phe and Pro) in response to interleukin-2. Kitson, R.P., Miller, C.A., Goldfarb, R.H. Nat. Immun. (1995) [Pubmed]
 
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