Disease relevance of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline

• Inhibition of respiratory enzymes is thus only a minor component of Photofrin-mediated (long incubation) phototoxicity in these cell lines and is overwhelmed by more significant damage elsewhere, whereas it is a major but not the exclusive element of death mediated by VBBO [1].

High impact information on 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline

• The triarylmethane derivative Victoria Blue-BO (VB-BO) and the chalcogenapyrylium (CP) dyes have potential for use in photochemotherapy, because they are taken up by the mitochondria of malignant cells and cause cell death [2].
• Statistical analysis of the data demonstrated minimal photobleaching of VBBO and a significant difference between the phototoxicity curves of ET3 and 2008 [1].
• Photosensitizers included Victoria Blue BO (VBBO; mitochondria); Photofrin with a short incubation, (plasma membrane) or a long incubation (intracellular membranes including mitochondria); and Nile Blue A (NBA; lysosomes) [1].

Biological context of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline

• Consistent with a mitochondrial localization of VBBO and independence from respiratory-chain damage, ET3 cells were less susceptible than 2008 to both dark- and light-activated VBBO-mediated damage [1].

Associations of 4-[(4-diethylaminophenyl)-(4-ethyliminonaphthalen-1-ylidene)methyl]-N,N-diethyl-aniline with other chemical compounds

• The MDR cell line was considerably more susceptible to VBBO than to the conventional agent doxorubicin [3].
• Thus MB and TBO may act on the MDR cell line via a different mechanism to that of VBBO [3].

References