Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Dadpe 4-(4-aminophenoxy)aniline

Synonyms: Oxydianiline, CCRIS 491, ARONIS016720, CHEMBL354663, NSC-6089, ...

Weisburger, E.K. et al., Mori, H. et al., Murthy, A.S. et al.

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Disease relevance of Oxydianiline

In addition to increasing thyroid adenomas in females and hepatocellular adenomas or carcinomas in male and female B6C3F1 mice, 4,4'- oxydianiline increased adenomas of the harderian gland in male and female mice [1].
4,4'- Oxydianiline (CAS: 101-80-4) in the diet increased adenomas and carcinomas in the thyroid gland and neoplastic nodules and carcinomas in the liver of male and female F344 rats [1].

High impact information on Oxydianiline

Effect of 4,4'-oxydianiline on the thyroid and pituitary glands of F344 rats: a morphologic study with the use of the immunoperoxidase method [2].
Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline [1].
DNA repair synthesis was elicited by 7 chemicals, i.e., 4-aminodiphenyl ether, 4,4-diaminodiphenyl ether, 3,4,4'-triaminodiphenyl ether, 3,3'-dichloro-4,4'-diaminodiphenyl ether, 1,3-phenylenedi-4-aminophenyl ether, 4,4'-diaminodiphenyl methane and 4,4'-methylene-bis(2-chloroaniline) [3].

References

Neoplastic response of F344 rats and B6C3F1 mice to the polymer and dyestuff intermediates 4,4'-methylenebis(N,N-dimethyl)-benzenamine, 4,4'-oxydianiline, and 4,4'-methylenedianiline. Weisburger, E.K., Murthy, A.S., Lilja, H.S., Lamb, J.C. J. Natl. Cancer Inst. (1984) [Pubmed]
Effect of 4,4'-oxydianiline on the thyroid and pituitary glands of F344 rats: a morphologic study with the use of the immunoperoxidase method. Murthy, A.S., Russfield, A.B., Snow, G.J. J. Natl. Cancer Inst. (1985) [Pubmed]
Genotoxicity of epoxy resin hardeners in the hepatocyte primary culture/DNA repair test. Mori, H., Yoshimi, N., Sugie, S., Iwata, H., Kawai, K., Mashizu, N., Shimizu, H. Mutat. Res. (1988) [Pubmed]

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