Chemical Compound Review:
homocysteine 2-amino-4-sulfanyl-butanoic acid
Synonyms:
homo-cys, PubChem19432, CHEMBL310604, ACMC-1B2D6, AG-F-57853, ...
Günther,
Sebeková,
Rafael Franco,
Lichtenstein,
Nowak-Göttl,
Susanna Genedani,
Carme Lluis,
Kurnik,
Susan J. Whiting,
Amina S. Woods,
Syrová,
Diego Guidolin,
Paulina Carriba,
Schobess,
Kjell Fuxe,
Kilmer S. McCully,
Jennifer A. McMahon,
Sergi Ferré,
Peter Nagele,
Barbara Zeugswetter,
Corinna Eberle,
Michael Hüpfl,
Martina Mittlböck,
Manuela Födinger,
Timothy J. Green,
Dzúrik,
Vicent Casadó,
C. Murray Skeaff,
Blazícek,
Monica Filaferro,
Sheila M. Williams,
Luigi F. Agnati,
Spustová,
Kreuz,
Junker,
Gazdíková,
Giuseppina Leo,
Kröning,
Nagami,
Heidland,
Schinzel,
Heller,
- Methionine requirement and replacement by homocysteine in tissue cultures of selected rodent and human malignant and normal cells. Kreis, W., Goodenow, M. Cancer Res. (1978)
- Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors. Woo, C.W., Siow, Y.L., Pierce, G.N., Choy, P.C., Minuk, G.Y., Mymin, D., O, K. Am. J. Physiol. Endocrinol. Metab. (2005)
- Factors affecting methionine toxicity and its alleviation in the chick. Harter, J.M., Baker, D.H. J. Nutr. (1978)
- Hyperhomocysteinemia, hyperfibrinogenemia, and lipoprotein (a) excess in maintenance dialysis patients: a matched case-control study. Bostom, A.G., Shemin, D., Lapane, K.L., Sutherland, P., Nadeau, M.R., Wilson, P.W., Yoburn, D., Bausserman, L., Tofler, G., Jacques, P.F., Selhub, J., Rosenberg, I.H. Atherosclerosis (1996)
- Experimental secondarily generalized convulsive status epilepticus induced by D,L-homocysteine thiolactone. Walton, N.Y., Treiman, D.M. Epilepsy Res. (1988)
- Homocysteine, vitamins, and vascular disease prevention. McCully, K.S. Am. J. Clin. Nutr. (2007)
- Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteine. Peyrin-Biroulet, L., Rodriguez-Guéant, R.M., Chamaillard, M., Desreumaux, P., Xia, B., Bronowicki, J.P., Bigard, M.A., Guéant, J.L. Am. J. Gastroenterol. (2007)
- Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. Alexandru, N., Jardín, I., Popov, D., Simionescu, M., García-Estañ, J., Salido, G.M., Rosado, J.A. J. Cell. Mol. Med. (2008)
- GABA receptors and nitric oxide ameliorate constrictive collagen remodeling in hyperhomocysteinemia. Shastry, S., Moning, L., Tyagi, N., Steed, M., Tyagi, S.C. J. Cell. Physiol. (2005)
- Homocysteine-induced modulation of tissue plasminogen activator binding to its endothelial cell membrane receptor. Hajjar, K.A. J. Clin. Invest. (1993)
- Tyrosinase inhibition due to interaction of homocyst(e)ine with copper: the mechanism for reversible hypopigmentation in homocystinuria due to cystathionine beta-synthase deficiency. Reish, O., Townsend, D., Berry, S.A., Tsai, M.Y., King, R.A. Am. J. Hum. Genet. (1995)
- Inhibition of ceramide-redox signaling pathway blocks glomerular injury in hyperhomocysteinemic rats. Yi, F., Zhang, A.Y., Li, N., Muh, R.W., Fillet, M., Renert, A.F., Li, P.L. Kidney Int. (2006)
- Sulfur-containing amino acids decrease cisplatin cytotoxicity and uptake in renal tubule epithelial cell lines. Kröning, R., Lichtenstein, A.K., Nagami, G.T. Cancer Chemother. Pharmacol. (2000)
- A study of micturition inducing sites in the periaqueductal gray of the mesencephalon. Taniguchi, N., Miyata, M., Yachiku, S., Kaneko, S., Yamaguchi, S., Numata, A. J. Urol. (2002)
- Effects of homocysteine on acetylcholine- and adenosine-induced vasodilatation of pancreatic vascular bed in rats. Quéré, I., Hillaire-Buys, D., Brunschwig, C., Chapal, J., Janbon, C., Blayac, J.P., Petit, P., Loubatières-Mariani, M.M. Br. J. Pharmacol. (1997)
- Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? Heil, S.G., Van der Put, N.M., Waas, E.T., den Heijer, M., Trijbels, F.J., Blom, H.J. Mol. Genet. Metab. (2001)
- Homocysteine stimulates MAP kinase in bovine aortic smooth muscle cells. Woo, D.K., Dudrick, S.J., Sumpio, B.E. Surgery (2000)
- The sigma receptor ligand (+)-pentazocine prevents apoptotic retinal ganglion cell death induced in vitro by homocysteine and glutamate. Martin, P.M., Ola, M.S., Agarwal, N., Ganapathy, V., Smith, S.B. Brain Res. Mol. Brain Res. (2004)
- Homocysteine-induced alterations in extracellular amino acids in rat hippocampus. Butcher, S.P., Cameron, D., Kendall, L., Griffiths, R. Neurochem. Int. (1992)
- Pioglitazone prevents cardiac remodeling in high-fat, high-calorie-induced Type 2 diabetes mellitus. Rodriguez, W.E., Joshua, I.G., Falcone, J.C., Tyagi, S.C. Am. J. Physiol. Heart Circ. Physiol. (2006)
- Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid. Luchowska, E., Luchowski, P., Paczek, R., Ziembowicz, A., Kocki, T., Turski, W.A., Wielosz, M., Lazarewicz, J., Urbanska, E.M. J. Neurosci. Res. (2005)
- Effect of dietary homocysteine on copper status in rats. Brown, J.C., Strain, J.J. J. Nutr. (1990)
- Allosteric modulation of dopamine D2 receptors by homocysteine. Agnati, L.F., Ferré, S., Genedani, S., Leo, G., Guidolin, D., Filaferro, M., Carriba, P., Casadó, V., Lluis, C., Franco, R., Woods, A.S., Fuxe, K. J. Proteome Res. (2006)
- Role of endoplasmic reticulum calcium disequilibria in the mechanism of homocysteine-induced ER stress. Dickhout, J.G., Sood, S.K., Austin, R.C. Antioxid. Redox Signal. (2007)
- Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial. Green, T.J., McMahon, J.A., Skeaff, C.M., Williams, S.M., Whiting, S.J. Am. J. Clin. Nutr. (2007)
- Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression. Kim, J.M., Stewart, R., Kim, S.W., Yang, S.J., Shin, I.S., Yoon, J.S. Br. J. Psychiatry (2008)
- Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors - a multicentre case-control study. For the Childhood Thrombophilia Study Group. Heller, C., Schobess, R., Kurnik, K., Junker, R., Günther, G., Kreuz, W., Nowak-Göttl, U. Br. J. Haematol. (2000)
- Effects of ramipril in nondiabetic nephropathy: improved parameters of oxidatives stress and potential modulation of advanced glycation end products. Sebeková, K., Gazdíková, K., Syrová, D., Blazícek, P., Schinzel, R., Heidland, A., Spustová, V., Dzúrik, R. Journal of human hypertension. (2003)
- Effect of homocysteine and homocystine on platelet and vascular arachidonic acid metabolism. Graeber, J.E., Slott, J.H., Ulane, R.E., Schulman, J.D., Stuart, M.J. Pediatr. Res. (1982)
- A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia. Nagele, P., Zeugswetter, B., Eberle, C., Hüpfl, M., Mittlböck, M., Födinger, M. Pharmacogenet. Genomics (2009)
- Hyperhomocysteinemia and vitamin B6 deficiency: new risk markers for nonvalvular atrial fibrillation? Marcucci, R., Betti, I., Cecchi, E., Poli, D., Giusti, B., Fedi, S., Lapini, I., Abbate, R., Gensini, G.F., Prisco, D. Am. Heart J. (2004)