Chemical Compound Review:
Thiophen thiophene
Synonyms:
THIOPHENE, Thiaphene, Thiofen, Thiofuram, Thiofuran, ...
Adam,
Bosio,
Fröhling,
Leusser,
Stalke,
Hagen,
Domagala,
Gajda,
Lovdahl,
Tait,
Wise,
Holler,
Hupe,
Nouhan,
Urumov,
Zeikus,
Zeikus,
Lunney,
Pavlovsky,
Gracheck,
Saunders,
VanderRoest,
Brodfuehrer,
Saczewski,
Reszka,
Gdaniec,
Grünert,
Bednarski,
D'Cruz,
Samuel,
Uckun,
Shaw-Reid,
Munshi,
Graham,
Wolfe,
Witmer,
Danzeisen,
Olsen,
Carroll,
Embrey,
Wai,
Miller,
Cole,
Hazuda,
Wu,
Decker,
Blok,
Li,
Bourgoyne,
Bui,
Keller,
Knowles,
Li,
Stavros,
Holland,
Brock,
Dixon,
Balsamo,
Coletta,
Guglielmotti,
Landolfi,
Mancini,
Martinelli,
Milanese,
Minutolo,
Nencetti,
Orlandini,
Pinza,
Rapposelli,
Rossello,
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- DNA protein cross-links produced by NSC 652287, a novel thiophene derivative active against human renal cancer cells. Nieves-Neira, W., Rivera, M.I., Kohlhagen, G., Hursey, M.L., Pourquier, P., Sausville, E.A., Pommier, Y. Mol. Pharmacol. (1999)
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- Synthesis, structure, and antiproliferative activity of selenophenfurin, an inosine 5'-monophosphate dehydrogenase inhibitor analogue of selenazofurin. Franchetti, P., Cappellacci, L., Sheikha, G.A., Jayaram, H.N., Gurudutt, V.V., Sint, T., Schneider, B.P., Jones, W.D., Goldstein, B.M., Perra, G., De Montis, A., Loi, A.G., La Colla, P., Grifantini, M. J. Med. Chem. (1997)
- Photophysical study of photoinduced electron transfer in a bis-thiophene substituted peryleneimide. Fron, E., Lor, M., Pilot, R., Schweitzer, G., Dincalp, H., De Feyter, S., Cremer, J., Bauerle, P., Mullen, K., Van der Auweraer, M., De Schryver, F.C. Photochem. Photobiol. Sci. (2005)
- Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid. Shaw-Reid, C.A., Munshi, V., Graham, P., Wolfe, A., Witmer, M., Danzeisen, R., Olsen, D.B., Carroll, S.S., Embrey, M., Wai, J.S., Miller, M.D., Cole, J.L., Hazuda, D.J. J. Biol. Chem. (2003)
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- pi-Stacking in thiophene oligomers as the driving force for electroactive materials and devices. Scherlis, D.A., Marzari, N. J. Am. Chem. Soc. (2005)
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- Desulfurization of diesel oils by a newly isolated dibenzothiophene-degrading Nocardia sp. strain CYKS2. Chang, J.H., Rhee, S.K., Chang, Y.K., Chang, H.N. Biotechnol. Prog. (1998)
- Amino derivatives of phenyl alkyl thiophene as inhibitors of bone resorption. Structure-activity relationship. Wierzbicki, M., Boussard, M.F., Sauveur, F., Kirsch, G., Sabatini, M., Lesur, C., Trodjman, C., Bonnet, J. Arzneimittel-Forschung. (1998)
- Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats. Mori, F., Tanji, K., Wakabayashi, K. Neuropathology : official journal of the Japanese Society of Neuropathology. (2000)
- Stability and selectivity of unnatural DNA with five-membered-ring nucleobase analogues. Berger, M., Luzzi, S.D., Henry, A.A., Romesberg, F.E. J. Am. Chem. Soc. (2002)
- Molecular structure and hepatotoxicity: compared data about two closely related thiophene compounds. Mansuy, D. J. Hepatol. (1997)
- [[[(Thienylcarbonyl)alkyl]oxy]phenyl]- and [[[(pyrrylcarbonyl)alkyl]oxy]phenyl]oxazoline derivatives with potent and selective antihuman rhinovirus activity. Massa, S., Corelli, F., Artico, M., Mai, A., Ragno, R., De Montis, A., Loi, A.G., Corrias, S., Marongiu, M.E., La Colla, P. J. Med. Chem. (1995)
- Acyl substitution at the ortho position of anilides enhances oral bioavailability of thiophene sulfonamides: TBC3214, an ETA selective endothelin antagonist. Wu, C., Decker, E.R., Blok, N., Li, J., Bourgoyne, A.R., Bui, H., Keller, K.M., Knowles, V., Li, W., Stavros, F.D., Holland, G.W., Brock, T.A., Dixon, R.A. J. Med. Chem. (2001)
- 2-Amino-3-aroyl-4,5-alkylthiophenes: agonist allosteric enhancers at human A(1) adenosine receptors. Tranberg, C.E., Zickgraf, A., Giunta, B.N., Luetjens, H., Figler, H., Murphree, L.J., Falke, R., Fleischer, H., Linden, J., Scammells, P.J., Olsson, R.A. J. Med. Chem. (2002)
- Synthesis, X-ray crystal structures, stabilities, and in vitro cytotoxic activities of new heteroarylacrylonitriles. Saczewski, F., Reszka, P., Gdaniec, M., Grünert, R., Bednarski, P.J. J. Med. Chem. (2004)
- Characterization of cutaneous phototoxicity induced by topical alpha-terthienyl and ultraviolet A radiation. Rampone, W.M., McCullough, J.L., Weinstein, G.D., Towers, G.H., Berns, M.W., Abeysekera, B. J. Invest. Dermatol. (1986)
- Thiophene systems. 5. Thieno[3,4-b][1,5]benzoxazepines, thieno[3,4-b][1,5]benzothiazepines, and thieno[3,4-b][1,4]benzodiazepines as potential central nervous system agents. Press, J.B., Hofmann, C.M., Eudy, N.H., Day, I.P., Greenblatt, E.N., Safir, S.R. J. Med. Chem. (1981)
- Hydroxylation and formation of electrophilic metabolites of tienilic acid and its isomer by human liver microsomes. Catalysis by a cytochrome P450 IIC different from that responsible for mephenytoin hydroxylation. Dansette, P.M., Amar, C., Valadon, P., Pons, C., Beaune, P.H., Mansuy, D. Biochem. Pharmacol. (1991)
- Genotoxicity of chryseno[4,5-bcd]thiophene and its sulfone derivative. Sinsheimer, J.E., Hooberman, B.H., Das, S.K., Savla, P.M., Ashe, A.J. Environ. Mol. Mutagen. (1992)
- Unusual sulfur chemistry in the thermal reaction of sultene and thiophene endoperoxide sulfur donors with cyclic alkynes: reversible formation of a persistent thiirenium ion and trapping of a thiirene by [4 + 2] cycloaddition. Adam, W., Bosio, S.G., Fröhling, B., Leusser, D., Stalke, D. J. Am. Chem. Soc. (2002)
- Thiophene-based diamidine forms a "super" at binding minor groove agent. Mallena, S., Lee, M.P., Bailly, C., Neidle, S., Kumar, A., Boykin, D.W., Wilson, W.D. J. Am. Chem. Soc. (2004)
- Highly selective, novel analogs of 4-[2-(diphenylmethoxy)ethyl]- 1-benzylpiperidine for the dopamine transporter: effect of different aromatic substitutions on their affinity and selectivity. Dutta, A.K., Coffey, L.L., Reith, M.E. J. Med. Chem. (1997)
- Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. Hodson, S.J., Bigham, E.C., Duch, D.S., Smith, G.K., Ferone, R. J. Med. Chem. (1994)
- Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid. López-Garcia, M.P., Dansette, P.M., Mansuy, D. Biochemistry (1994)
- Isolation and genetic analysis of mutations allowing the degradation of furans and thiophenes by Escherichia coli. Abdulrashid, N., Clark, D.P. J. Bacteriol. (1987)
- Carbonic anhydrase inhibitors: sulfonamides incorporating furan-, thiophene- and pyrrole-carboxamido groups possess strong topical intraocular pressure lowering properties as aqueous suspensions. Ilies, M., Supuran, C.T., Scozzafava, A., Casini, A., Mincione, F., Menabuoni, L., Caproiu, M.T., Maganu, M., Banciu, M.D. Bioorg. Med. Chem. (2000)
- Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring. Balsamo, A., Coletta, I., Guglielmotti, A., Landolfi, C., Mancini, F., Martinelli, A., Milanese, C., Minutolo, F., Nencetti, S., Orlandini, E., Pinza, M., Rapposelli, S., Rossello, A. European journal of medicinal chemistry. (2003)
- Synthesis and biological evaluation of novel macrocyclic bis-7-azaindolylmaleimides as potent and highly selective glycogen synthase kinase-3 beta (GSK-3 beta) inhibitors. Shen, L., Prouty, C., Conway, B.R., Westover, L., Xu, J.Z., Look, R.A., Chen, X., Beavers, M.P., Roberts, J., Murray, W.V., Demarest, K.T., Kuo, G.H. Bioorg. Med. Chem. (2004)
- Electron-induced switching of the supramolecular chirality of optically active polythiophene aggregates. Goto, H., Yashima, E. J. Am. Chem. Soc. (2002)
- Label-free electrochemical detection of protein based on a ferrocene-bearing cationic polythiophene and aptamer. Le Floch, F., Ho, H.A., Leclerc, M. Anal. Chem. (2006)
- Molecular cloning and sequence of the thdF gene, which is involved in thiophene and furan oxidation by Escherichia coli. Alam, K.Y., Clark, D.P. J. Bacteriol. (1991)
- Design and synthesis of push-pull chromophores for second-order nonlinear optics derived from rigidified thiophene-based pi-conjugating spacers. Raimundo, J.M., Blanchard, P., Gallego-Planas, N., Mercier, N., Ledoux-Rak, I., Hierle, R., Roncali, J. J. Org. Chem. (2002)