Chemical Compound Review:
Drewamine morpholine
Synonyms:
morpholin, MORPHOLINE, Tetrahydro-1,4, SureCN986, PubChem15002, ...
- In vivo formation of N-nitrosomorpholine in CD-1 mice exposed by inhalation to nitrogen dioxide and by gavage to morpholine. Van Stee, E.W., Sloane, R.A., Simmons, J.E., Brunnemann, K.D. J. Natl. Cancer Inst. (1983)
- Degradation of morpholine by an environmental Mycobacterium strain involves a cytochrome P-450. Poupin, P., Truffaut, N., Combourieu, B., Besse, P., Sancelme, M., Veschambre, H., Delort, A.M. Appl. Environ. Microbiol. (1998)
- Selective inhibition of osteoclast vacuolar H(+)-ATPase. Farina, C., Gagliardi, S. Curr. Pharm. Des. (2002)
- The anti-proliferative properties of 4-benzylphenoxy ethanamine derivatives are mediated by the anti-estrogen binding site (ABS), whereas the anti-estrogenic effects of trifluopromazine are not. Poirot, M., Garnier, M., Bayard, F., Riviere, I., Traore, M., Wilson, M., Fargin, A., Faye, J.C. Biochem. Pharmacol. (1990)
- In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands. Zhang, Q., Ma, P., Wang, W., Cole, R.B., Wang, G. Drug Metab. Dispos. (2005)
- Role of nitrogen dioxide in the biosynthesis of nitraosamines in mice. Iqbal, Z.M., Dahl, K., Epstein, S.S. Science (1980)
- Reaction of nitrite with ascorbate and its relation to nitrosamine formation. Archer, M.C., Tannenbaum, S.R., Fan, T.Y., Weisman, M. J. Natl. Cancer Inst. (1975)
- Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral embryonic axes. Angerer, L.M., Oleksyn, D.W., Levine, A.M., Li, X., Klein, W.H., Angerer, R.C. Development (2001)
- Bicarbonate inhibits N-nitrosation in oxygenated nitric oxide solutions. Caulfield, J.L., Singh, S.P., Wishnok, J.S., Deen, W.M., Tannenbaum, S.R. J. Biol. Chem. (1996)
- Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: relevance to catalytic amination. Lewis, A.K., Caddick, S., Cloke, F.G., Billingham, N.C., Hitchcock, P.B., Leonard, J. J. Am. Chem. Soc. (2003)
- Effect of sodium ascorbate on tumor induction in rats treated with morpholine and sodium nitrite, and with nitrosomorpholine. Mirvish, S.S., Pelfrene, A.F., Garcia, H., Shubik, P. Cancer Lett. (1976)
- Molecular cloning, nucleotide sequencing and expression of genes encoding a cytochrome P450 system involved in secondary amine utilization in Mycobacterium sp. strain RP1. Trigui, M., Pulvin, S., Truffaut, N., Thomas, D., Poupin, P. Res. Microbiol. (2004)
- The relative efficacy of 0.1% and 0.2% delmopinol mouthrinses in inhibiting the development of supragingival dental plaque and gingivitis in man. Abbott, D.M., Gunsolley, J.C., Koertge, T.E., Payne, E.L. J. Periodontol. (1994)
- Experimental models for the biological detection of N-nitroso compounds formed from amines and nitrite. Baumeister, M. Toxicol. Lett. (1982)
- Thiomorpholine and morpholine oxidation by a cytochrome P450 in Mycobacterium aurum MO1. Evidence of the intermediates by in situ 1H NMR. Combourieu, B., Poupin, P., Besse, P., Sancelme, M., Veschambre, H., Truffaut, N., Delort, A.M. Biodegradation (1998)
- Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides. Caulfield, J.L., Wishnok, J.S., Tannenbaum, S.R. J. Biol. Chem. (1998)
- Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. Iversen, P.L., Arora, V., Acker, A.J., Mason, D.H., Devi, G.R. Clin. Cancer Res. (2003)
- Nitrobenzyl derivatives as bioreductive alkylating agents: evidence for the reductive formation of a reactive intermediate. Kirkpatrick, D.L., Johnson, K.E., Sartorelli, A.C. J. Med. Chem. (1986)
- Novel opiates and antagonists. 4. 7-Alkanoylhydromorphones. Quick, J., Herlihy, P., Razdan, R.K., Howes, J.F. J. Med. Chem. (1982)
- Nitrosation of amines by stimulated macrophages. Miwa, M., Stuehr, D.J., Marletta, M.A., Wishnok, J.S., Tannenbaum, S.R. Carcinogenesis (1987)
- L-arginine-dependent formation of N-nitrosamines by the cytosol of macrophages activated with lipopolysaccharide and interferon-gamma. Ohshima, H., Tsuda, M., Adachi, H., Ogura, T., Sugimura, T., Esumi, H. Carcinogenesis (1991)
- Lack of differential sensitivity of normal hematopoietic stem cells and murine lymphoblastic leukemic cells to a lysosomotropic agent, N-dodecyl morpholine. Lopez, M., Sainteny, F., Kinsky, R., Bony, V. Leukemia (1988)
- Conformational effects on the activity of drugs. 10. Synthesis, conformation, and pharmacological properties of 1-(2,5-dimethoxyphenyl)-2-aminoethanols and their morpholine analogues. Epifani, E., Lapucci, A., Macchia, B., Macchia, F., Tognetti, P., Breschi, M.C., Del Tacca, M., Martinotti, E., Giovannini, L. J. Med. Chem. (1983)
- Screening of microorganisms for nitrosation catalysis at pH 7 and kinetic studies on nitrosamine formation from secondary amines by E. coli strains. Calmels, S., Ohshima, H., Vincent, P., Gounot, A.M., Bartsch, H. Carcinogenesis (1985)
- Synthesis of nitric oxide and nitrosamine by immortalized woodchuck hepatocytes. Liu, R.H., Jacob, J.R., Hotchkiss, J.H., Tennant, B.C. Carcinogenesis (1993)
- Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist. Hale, J.J., Mills, S.G., MacCoss, M., Finke, P.E., Cascieri, M.A., Sadowski, S., Ber, E., Chicchi, G.G., Kurtz, M., Metzger, J., Eiermann, G., Tsou, N.N., Tattersall, F.D., Rupniak, N.M., Williams, A.R., Rycroft, W., Hargreaves, R., MacIntyre, D.E. J. Med. Chem. (1998)
- N-(2-hydroxyethyl)doxorubicin from hydrolysis of 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin. Acton, E.M., Tong, G.L., Smith, T.H., Taylor, D.L., Streeter, D.G., Peters, J.H., Gordon, G.R., Filppi, J.A., Wolgemuth, R.L., Giuliani, F.C. J. Med. Chem. (1986)
- Biochemical studies on the catalysis of nitrosation by bacteria. Calmels, S., Ohshima, H., Rosenkranz, H., McCoy, E., Bartsch, H. Carcinogenesis (1987)
- The identification of a gene family in the Saccharomyces cerevisiae ergosterol biosynthesis pathway. Lai, M.H., Bard, M., Pierson, C.A., Alexander, J.F., Goebl, M., Carter, G.T., Kirsch, D.R. Gene (1994)
- A mutation in sphingolipid synthesis suppresses defects in yeast ergosterol metabolism. Valachovic, M., Wilcox, L.I., Sturley, S.L., Bard, M. Lipids (2004)
- Investigation of the role of sterol delta 8-->7-isomerase in the sensitivity of Saccharomyces cerevisiae to fenpropimorph. Kelly, D.E., Rose, M.E., Kelly, S.L. FEMS Microbiol. Lett. (1994)
- From moclobemide to Ro 19-6327 and Ro 41-1049: the development of a new class of reversible, selective MAO-A and MAO-B inhibitors. Da Prada, M., Kettler, R., Keller, H.H., Cesura, A.M., Richards, J.G., Saura Marti, J., Muggli-Maniglio, D., Wyss, P.C., Kyburz, E., Imhof, R. J. Neural Transm. Suppl. (1990)
- Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Pickens, J.C., Merritt, E.A., Ahn, M., Verlinde, C.L., Hol, W.G., Fan, E. Chem. Biol. (2002)
- Separation of morpholine and some of its metabolites by high-performance liquid chromatography. Sohn, O.S., Fiala, E.S., Conaway, C.C., Weisburger, J.H. J. Chromatogr. (1982)
- Determination of morpholine in air by derivatisation with 1-naphthylisothiocyanate and HPLC analysis. Lindahl, R., Wästerby, A., Levin, J.O. The Analyst. (2001)
- Metabolic disposition of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat, dog and man. McKillop, D., Hutchison, M., Partridge, E.A., Bushby, N., Cooper, C.M., Clarkson-Jones, J.A., Herron, W., Swaisland, H.C. Xenobiotica (2004)
- Degradation of morpholine by Mycobacterium aurum MO1. Mazure, N., Truffaut, N. Can. J. Microbiol. (1994)