Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

ACV-MP 2-[(2-amino-6-oxo-3H-purin- 9...

Synonyms: Acyclo-GMP, CHEMBL517814, AG-G-50224, AR-1D5512, AC1L36LA, ...

Derse, D. et al., Elion, G.B.

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Disease relevance of Acyclovir-monophosphate

Kinetic experiments with variable concentrations of activated DNA and fixed concentrations of acyclo-GMP-terminated DNA revealed a noncompetitive inhibition of HSV-1 DNA polymerase [1].

High impact information on Acyclovir-monophosphate

Finally, 14C-labeled acyclo-GMP residues incorporated into activated DNA by HSV-1 DNA polymerase could not be excised by the polymerase-associated 3',5'-exonuclease activity [1].
The viral DNA polymerase binds strongly to the acyclo-GMP-terminated template, and in thereby inactivated [2].

References

Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function. Derse, D., Cheng, Y.C., Furman, P.A., St Clair, M.H., Elion, G.B. J. Biol. Chem. (1981) [Pubmed]
Mechanism of action and selectivity of acyclovir. Elion, G.B. Am. J. Med. (1982) [Pubmed]

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