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Chemical Compound Review

POLY I     [(2R,3S,4R,5R)-3,4-dihydroxy- 5-(6-oxo-3H...

Synonyms: PolyI, Polyinosine, Inosinic acid, SureCN19255, IMP, ...
 
 
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High impact information on Polyinosinic acids

  • We identified inosine-5-monophosphate dehydrogenase in each of the cell lines, and found the levels of this enzyme in the tumor cell lines elevated 2- to 20-fold relative to the levels in normal cells [1].
  • PKB/Akt interacts with inosine-5' monophosphate dehydrogenase through its pleckstrin homology domain [2].
  • Poly(rI) . poly(rC), and mouse macrophage interferon [i.e. serum from mice treated with poly(rI) . poly(rC)] protected mice equally against infections with the two viruses, but fibroblast interferon protected better against infection with the interferon-sensitive mutant than with the wild-type virus [3].
  • C. parapsilosis cells were transformed with a plasmid vector containing the Candida albicans inosine monophosphate dehydrogenase gene (IMH3) responsible for mycophenolic acid resistance [4].

References

 
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