High impact information on Dabco crystal

• One-dimensional dielectric (N.H.N)( infinity ) hydrogen-bonding chains of monoprotonated 1,4-diazabicyclo[2.2.2]octane (HDABCO(+)) were introduced into an electrically conducting 7,7,8,8-tetracyano-p-quinodimethane (TCNQ) salt as the countercation structure [1].
• In this study, we synthesized three classes of novel polyammonium compounds incorporating the bicyclic unit 1,4-diazabicyclo[2.2.2]octane (DABCO) and tested their action on three representative mammalian Kv channels (Kv2.1, Kv3.4, and Kv4.2) expressed in Xenopus laevis oocytes [2].
• Accumulation of heme oxygenase-1 and c-fos transcripts was abrogated in cells pretreated with 1,4-diazabicyclo[2.2.2]octane, an oxygen-free radical quencher [3].
• Titrations carried out by UV-visible and (1)H NMR spectroscopy have been used to map out the stabilities and the stoichiometries of the complexes formed with 1,4-diazabicyclo[2.2.2]octane (DABCO) in chloroform [4].
• Mechanochemical preparation of hydrogen-bonded adducts between the diamine 1,4-diazabicyclo[2.2.2]octane and dicarboxylic acids of variable chain length: an X-ray diffraction and solid-state NMR study [5].

Biological context of Dabco crystal

• In experiments with singlet oxygen scavengers, sodium azide and dGMP inhibited the DNA damage completely, whereas neither 1,4-diazabicyclo[2.2.2]octane nor dimethylfuran inhibited it [6].
• Competition experiments indicate that TEDA displaces CO to less strong binding sites [7].

Anatomical context of Dabco crystal

• In a second series of experiments, bronchial epithelial cells labeled with (I) were treated with singlet oxygen in the presence of 1,4-diazabicyclo[2.2.2]octane, a singlet oxygen quenching agent [8].

Associations of Dabco crystal with other chemical compounds

• The algorithm has been applied successfully to the prediction of the crystal structures of 3-aza-bicyclo(3.3.1)nonane-2,4-dione (P2(1)/a, Z' = 1), allopurinol (P2(1)/c, Z' = 1), 1,3,4,6,7,9-hexa-azacycl(3.3.3)azine (Pbca, Z' = 2), and triethylenediamine (P6(3)/m, Z' = 1) [9].
• There was little or no improvement in the median survival times of Drosophila melanogaster fruit flies when fed high concentrations of the singlet oxygen quenchers, beta-carotene and 1,4-diazabicyclo(2.2.2)octane [10].

Analytical, diagnostic and therapeutic context of Dabco crystal

• Two kinds of respirator canisters, an organic vapor (OV) canister containing activated carbon and a methyl bromide (MB) canister containing activated carbon impregnated with triethylenediamine were investigated for their filtration efficiency of MB gas under various conditions of MB concentration, humidity and temperature [11].
• The coadsorption of CO and triethylenediamine (TEDA) (also called 1,4-diazabicyclo[2.2.2]octane, DABCO) on a high-area gamma-Al2O3 surface has been investigated with use of transmission FTIR spectroscopy [7].

References