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Chemical Compound Review

Anadrol     (5S,8R,9S,10S,13S,14S,17S)- 17-hydroxy-2...

Synonyms: Adroyd, oxymetholone, SureCN145160, CI-406, AC1L1U2W, ...
 
 
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Disease relevance of Anadrol

 

High impact information on Anadrol

  • The response to nandrolone and testosterone enanthate, the two drugs given by injection, was clearly superior to the response to oxymetholone or fluoxymesterone, given by mouth, in terms of the percentage of patients responding and the mean rise in hematocrit [5].
  • The patient was a 6-year-old girl with FA and myelodysplasia previously treated with oxymetholone and prednisone [6].
  • RESULTS: Oxymetholone led to a significant weight gain of 3.0 +/- 0.5 and 3.5 +/- 0.7 kg in the TID and BID groups, respectively (P < 0.05 for each treatment versus placebo), whereas individuals in the placebo group gained an average of 1.0 +/- 0.7 kg [7].
  • Body cell mass increased in the oxymetholone BID group (3.8 +/- 0.4 kg; P < 0.0001) and in the oxymetholone TID group (2.1 +/- 0.6 kg; P < 0.005), corresponding to 12.4 and 7.4% of baseline BCM, respectively [7].
  • Overall, 35% of patients in the TID, 27% of patients in the BID oxymetholone group and no patients in the placebo group had a greater than five times baseline increase for alanine aminotransferase during the double-blind phase of the study [7].
 

Chemical compound and disease context of Anadrol

 

Biological context of Anadrol

 

Anatomical context of Anadrol

 

Associations of Anadrol with other chemical compounds

 

Gene context of Anadrol

 

Analytical, diagnostic and therapeutic context of Anadrol

References

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  2. Hyperlipidemia due to oxymetholone therapy. Occurrence in a long-term hemodialysis patient. Reeves, R.D., Morris, M.D., Barbour, G.L. JAMA (1976) [Pubmed]
  3. Immunosuppressive therapy of aplastic anemia: results of a prospective, randomized trial of antithymocyte globulin (ATG), methylprednisolone, and oxymetholone to ATG, very high-dose methylprednisolone, and oxymetholone. Doney, K., Pepe, M., Storb, R., Bryant, E., Anasetti, C., Appelbaum, F.R., Buckner, C.D., Sanders, J., Singer, J., Sullivan, K. Blood (1992) [Pubmed]
  4. Oxymetholone treatment for sickle cell anemia. Alexanian, R., Nadell, J. Blood (1975) [Pubmed]
  5. A comparison of androgens for anemia in patients on hemodialysis. Neff, M.S., Goldberg, J., Slifkin, R.F., Eiser, A.R., Calamia, V., Kaplan, M., Baez, A., Gupta, S., Mattoo, N. N. Engl. J. Med. (1981) [Pubmed]
  6. Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis. Grewal, S.S., Kahn, J.P., MacMillan, M.L., Ramsay, N.K., Wagner, J.E. Blood (2004) [Pubmed]
  7. Double-blind, randomized, placebo-controlled phase III trial of oxymetholone for the treatment of HIV wasting. Hengge, U.R., Stocks, K., Wiehler, H., Faulkner, S., Esser, S., Lorenz, C., Jentzen, W., Hengge, D., Goos, M., Dudley, R.E., Ringham, G. AIDS (2003) [Pubmed]
  8. Glucose intolerance and insulin resistance in aplastic anemia treated with oxymetholone. Woodard, T.L., Burghen, G.A., Kitabchi, A.E., Wilimas, J.A. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  9. Oxymetholone therapy in patients with familial antithrombin III deficiency. Shibuya, A., Ninomiya, H., Nakazawa, M., Nagasawa, T., Yoda, Y., Abe, T. Thromb. Haemost. (1988) [Pubmed]
  10. Transponder-induced sarcoma in the heterozygous p53+/- mouse. Blanchard, K.T., Barthel, C., French, J.E., Holden, H.E., Moretz, R., Pack, F.D., Tennant, R.W., Stoll, R.E. Toxicologic pathology. (1999) [Pubmed]
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  12. Androgens and liver tumors: Fanconi's anemia and non-Fanconi's conditions. Velazquez, I., Alter, B.P. Am. J. Hematol. (2004) [Pubmed]
  13. Oxymetholone and erythropoiesis: failure to detect an effect in fetal mouse liver cell cultures. Dunn, C.D., Napier, J.A., Ford, T.W., Price, V.A. Exp. Hematol. (1977) [Pubmed]
  14. Perturbations of the human menstrual cycle by oxymetholone. Cox, D.W., Heinrichs, W.L., Paulsen, A.C., Conrad, S.H., Schiller, H.S., Hezl, M.R., Herrmann, W.L. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  15. Effect of oxymetholone on human cyclic haematopoiesis. Roozendaal, K.J., Dicke, K.A., Boonzajer Flaes, M.L. Br. J. Haematol. (1981) [Pubmed]
  16. Review of oxymetholone: a 17alpha-alkylated anabolic-androgenic steroid. Pavlatos, A.M., Fultz, O., Monberg, M.J., Vootkur, A., Pharmd, n.u.l.l. Clinical therapeutics. (2001) [Pubmed]
  17. Androgen dependency in acquired aplastic anemia. Azen, E.A., Shahidi, N.T. Am. J. Med. (1977) [Pubmed]
  18. Regression on oxymetholone-induced hepatic tumors after bone marrow transplantation in aplastic anemia. Montgomery, R.R., Ducore, J.M., Githens, J.H., August, C.S., Johnson, M.L. Transplantation (1980) [Pubmed]
  19. Effect of a single oral dose of oxymetholone on the metabolism of human erythrocytes. Molinari, P.F., Neri, L.L. Exp. Hematol. (1978) [Pubmed]
  20. Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. Schroeder, E.T., Singh, A., Bhasin, S., Storer, T.W., Azen, C., Davidson, T., Martinez, C., Sinha-Hikim, I., Jaque, S.V., Terk, M., Sattler, F.R. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  21. Clinical and biochemical effects of impeded androgen (oxymetholone) therapy of hereditary angioedema. Sheffer, A.L., Fearon, D.T., Austen, K.F. J. Allergy Clin. Immunol. (1979) [Pubmed]
  22. Comparison of the effects of stanozolol, oxymetholone, and testosterone cypionate on the sexual behavior of castrated male rats. Clark, A.S., Harrold, E.V. Behav. Neurosci. (1997) [Pubmed]
  23. Intracerebroventricular self-administration of commonly abused anabolic-androgenic steroids in male hamsters (Mesocricetus auratus): nandrolone, drostanolone, oxymetholone, and stanozolol. Ballard, C.L., Wood, R.I. Behav. Neurosci. (2005) [Pubmed]
  24. Increased dopaminergic and 5-hydroxytryptaminergic activities in male rat brain following long-term treatment with anabolic androgenic steroids. Thiblin, I., Finn, A., Ross, S.B., Stenfors, C. Br. J. Pharmacol. (1999) [Pubmed]
  25. Oxymetholone: I. Evaluation in a comprehensive battery of genetic toxicology and in vitro transformation assays. Holden, H.E., Studwell, D., Majeska, J.B. Toxicologic pathology. (1999) [Pubmed]
  26. Effect of oxymetholone on left ventricular dimensions in heart failure secondary to idiopathic dilated cardiomyopathy or to mitral or aortic regurgitation. Tomoda, H. Am. J. Cardiol. (1999) [Pubmed]
  27. Abnormal cytogenetic clones in patients with aplastic anaemia: response to immunosuppressive therapy. Geary, C.G., Harrison, C.J., Philpott, N.J., Hows, J.M., Gordon-Smith, E.C., Marsh, J.C. Br. J. Haematol. (1999) [Pubmed]
  28. Oxymetholone: III. Evaluation in the p53+/- transgenic mouse model. Stoll, R.E., Holden, H.E., Barthel, C.H., Blanchard, K.T. Toxicologic pathology. (1999) [Pubmed]
  29. Oxymetholone: II. Evaluation in the Tg-AC transgenic mouse model for detection of carcinogens. Holden, H.E., Stoll, R.E., Blanchard, K.T. Toxicologic pathology. (1999) [Pubmed]
  30. Oral oxymetholone reduces mortality induced by gamma irradiation in mice through stimulation of hematopoietic cells. Hosseinimehr, S.J., Zakaryaee, V., Froughizadeh, M. Mol. Cell. Biochem. (2006) [Pubmed]
 
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