Gene Review:
BCL2L11 - BCL2-like 11 (apoptosis facilitator)
Homo sapiens
Synonyms:
BAM, BIM, BOD, Bcl-2-like protein 11, Bcl2-L-11, ...
- Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737. Del Gaizo Moore, V., Brown, J.R., Certo, M., Love, T.M., Novina, C.D., Letai, A. J. Clin. Invest. (2007)
- Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim. Liu, J.W., Chandra, D., Tang, S.H., Chopra, D., Tang, D.G. Cancer Res. (2002)
- Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. Abrams, M.T., Robertson, N.M., Yoon, K., Wickstrom, E. J. Biol. Chem. (2004)
- Requirement for JNK-dependent upregulation of BimL in anti-IgM-induced apoptosis in murine B lymphoma cell lines WEHI-231 and CH31. Takada, E., Hata, K., Mizuguchi, J. Exp. Cell Res. (2006)
- BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. Fukazawa, H., Noguchi, K., Masumi, A., Murakami, Y., Uehara, Y. Mol. Cancer Ther. (2004)
- JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Putcha, G.V., Le, S., Frank, S., Besirli, C.G., Clark, K., Chu, B., Alix, S., Youle, R.J., LaMarche, A., Maroney, A.C., Johnson, E.M. Neuron (2003)
- Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Putcha, G.V., Moulder, K.L., Golden, J.P., Bouillet, P., Adams, J.A., Strasser, A., Johnson, E.M. Neuron (2001)
- TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. Gressner, O., Schilling, T., Lorenz, K., Schulze Schleithoff, E., Koch, A., Schulze-Bergkamen, H., Maria Lena, A., Candi, E., Terrinoni, A., Valeria Catani, M., Oren, M., Melino, G., Krammer, P.H., Stremmel, W., Müller, M. EMBO J. (2005)
- Regulation of the proapoptotic BH3-only protein BIM by glucocorticoids, survival signals and proteasome in chronic lymphocytic leukemia cells. Iglesias-Serret, D., de Frias, M., Santidrián, A.F., Coll-Mulet, L., Cosialls, A.M., Barragán, M., Domingo, A., Gil, J., Pons, G. Leukemia (2007)
- Spontaneous and cAMP-dependent induction of a resting phase and neurite formation in cell hybrids between human neuroblastoma cells and thymidine auxotrophs of rat nerve-like cells. Ishii, K., Adachi, Y., Hatanaka, M., Sakamoto, H., Furuyama, J. J. Cell. Physiol. (1990)
- Compared effects of GnRH analogs and 4-hydroxytamoxifen on growth and steroid receptors in antiestrogen sensitive and resistant MCF-7 breast cancer cell sublines. Néri, C., Berthois, Y., Schatz, B., Drieu, K., Martin, P.M. Breast Cancer Res. Treat. (1990)
- Melanotropins as growth factors. Strand, F.L., Zuccarelli, L.A., Williams, K.A., Lee, S.J., Lee, T.S., Antonawich, F.J., Alves, S.E. Ann. N. Y. Acad. Sci. (1993)
- Sleep-wake study in an animal model of acute and chronic heat stress. Sinha, R.K., Ray, A.K. Physiol. Behav. (2006)
- Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids. Murray, S., Halford, S., Ebenezer, N.D., Gregory-Evans, C.Y., Bhattacharya, S.S. Cytogenet. Cell Genet. (2001)
- Autosomal dominant acute necrotizing encephalopathy maps to 2q12.1-2q13. Neilson, D.E., Feiler, H.S., Wilhelmsen, K.C., Lynn, A., Eiben, R.M., Kerr, D.S., Warman, M.L. Ann. Neurol. (2004)
- Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex. Gomez-Bougie, P., Oliver, L., Le Gouill, S., Bataille, R., Amiot, M. Oncogene (2005)
- Bcl-XL protects BimEL-induced Bax conformational change and cytochrome C release independent of interacting with Bax or BimEL. Yamaguchi, H., Wang, H.G. J. Biol. Chem. (2002)
- JNK inhibitory kinase is up-regulated in retinal ganglion cells after axotomy and enhances BimEL expression level in neuronal cells. Wakabayashi, T., Kosaka, J., Oshika, T. J. Neurochem. (2005)
- Activation of Erk1/Erk2 and transiently increased p53 levels together may account for p21 expression associated with phorbol ester-induced transient growth inhibition in HepG2 cells. Sipeki, S., Bander, E., Ways, D.K., Faragó, A. Cell. Signal. (2002)
- Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis. Lund, T., Stokke, T., Olsen, Ø.E., Fodstad, Ø. Br. J. Cancer (2005)
- Adjuvant hormonal treatment with peptide YY or its analog decreases human pancreatic carcinoma growth. Liu, C.D., Rongione, A.J., Garvey, L., Balasubramaniam, A., McFadden, D.W. Am. J. Surg. (1996)
- Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. Becker, E.B., Howell, J., Kodama, Y., Barker, P.A., Bonni, A. J. Neurosci. (2004)
- MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Nishito, Y., Hasegawa, M., Inohara, N., Núñez, G. Biochem. J. (2006)
- RACK1 and CIS mediate the degradation of BimEL in cancer cells. Zhang, W., Cheng, G.Z., Gong, J., Hermanto, U., Zong, C.S., Chan, J., Cheng, J.Q., Wang, L.H. J. Biol. Chem. (2008)
- BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes. Terrones, O., Etxebarria, A., Landajuela, A., Landeta, O., Antonsson, B., Basañez, G. J. Biol. Chem. (2008)
- OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells. Yacoub, A., Park, M.A., Hanna, D., Hong, Y., Mitchell, C., Pandya, A.P., Harada, H., Powis, G., Chen, C.S., Koumenis, C., Grant, S., Dent, P. Mol. Pharmacol. (2006)
- p38 MAP kinase mediates apoptosis through phosphorylation of BimEL at Ser-65. Cai, B., Chang, S.H., Becker, E.B., Bonni, A., Xia, Z. J. Biol. Chem. (2006)
- Endogenous association of Bim BH3-only protein with Mcl-1, Bcl-xL and Bcl-2 on mitochondria in human B cells. Gomez-Bougie, P., Bataille, R., Amiot, M. Eur. J. Immunol. (2005)
- BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu, S.Y., Lin, P., Hsueh, A.J. Mol. Endocrinol. (1998)
- Cytoprotective peptide humanin binds and inhibits proapoptotic Bcl-2/Bax family protein BimEL. Luciano, F., Zhai, D., Zhu, X., Bailly-Maitre, B., Ricci, J.E., Satterthwait, A.C., Reed, J.C. J. Biol. Chem. (2005)
- C-terminal parathyroid hormone-related protein (PTHrP) (107-139) stimulates intracellular Ca(2+) through a receptor different from the type 1 PTH/PTHrP receptor in osteoblastic osteosarcoma UMR 106 cells. Valín, A., Guillén, C., Esbrit, P. Endocrinology (2001)